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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37520

FusionGeneSummary for TC2N_LPP

check button Fusion gene summary
Fusion gene informationFusion gene name: TC2N_LPP
Fusion gene ID: 37520
HgeneTgene
Gene symbol

TC2N

LPP

Gene ID

123036

4026

Gene nametandem C2 domains, nuclearLIM domain containing preferred translocation partner in lipoma
SynonymsC14orf47|C2CD1|MTAC2D1|Tac2-N-
Cytomap

14q32.12

3q27.3-q28

Type of geneprotein-codingprotein-coding
Descriptiontandem C2 domains nuclear proteinC2 calcium-dependent domain containing 1membrane targeting (tandem) C2 domain containing 1tandem C2 protein in nucleuslipoma-preferred partnerLIM proteinlipoma preferred partner
Modification date2018052220180519
UniProtAcc

Q8N9U0

Q93052

Ensembl transtripts involved in fusion geneENST00000435962, ENST00000340892, 
ENST00000360594, ENST00000556018, 
ENST00000555302, 
ENST00000448637, 
ENST00000312675, ENST00000543006, 
ENST00000471917, 
Fusion gene scores* DoF score4 X 3 X 4=4812 X 17 X 5=1020
# samples 620
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(20/1020*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TC2N [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-5668-01ATC2Nchr14

92280047

-LPPchr3

188583988

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000435962ENST00000448637TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000435962ENST00000312675TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000435962ENST00000543006TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000435962ENST00000471917TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000340892ENST00000448637TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000340892ENST00000312675TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000340892ENST00000543006TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000340892ENST00000471917TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000360594ENST00000448637TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000360594ENST00000312675TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000360594ENST00000543006TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000360594ENST00000471917TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000556018ENST00000448637TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000556018ENST00000312675TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000556018ENST00000543006TC2Nchr14

92280047

-LPPchr3

188583988

+
5CDS-intronENST00000556018ENST00000471917TC2Nchr14

92280047

-LPPchr3

188583988

+
intron-intronENST00000555302ENST00000448637TC2Nchr14

92280047

-LPPchr3

188583988

+
intron-intronENST00000555302ENST00000312675TC2Nchr14

92280047

-LPPchr3

188583988

+
intron-intronENST00000555302ENST00000543006TC2Nchr14

92280047

-LPPchr3

188583988

+
intron-intronENST00000555302ENST00000471917TC2Nchr14

92280047

-LPPchr3

188583988

+

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FusionProtFeatures for TC2N_LPP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TC2N

Q8N9U0

LPP

Q93052

May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TC2N_LPP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TC2N_LPP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TC2NELAVL1, ERRFI1, GPBP1L1, EAF1LPPATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TC2N_LPP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TC2N_LPP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLPPC3495559Juvenile arthritis1CTD_human