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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37505

FusionGeneSummary for TBRG4_NEMF

check button Fusion gene summary
Fusion gene informationFusion gene name: TBRG4_NEMF
Fusion gene ID: 37505
HgeneTgene
Gene symbol

TBRG4

NEMF

Gene ID

9238

9147

Gene nametransforming growth factor beta regulator 4nuclear export mediator factor
SynonymsCPR2|FASTKD4NY-CO-1|SDCCAG1
Cytomap

7p13

14q21.3

Type of geneprotein-codingprotein-coding
DescriptionFAST kinase domain-containing protein 4FAST kinase domains 4H_TD2522F11.8cell cycle progression protein 2cell cycle progression restoration protein 2protein TBRG4nuclear export mediator factor NEMFantigen NY-CO-1serologically defined colon cancer antigen 1
Modification date2018051920180523
UniProtAcc

Q969Z0

O60524

Ensembl transtripts involved in fusion geneENST00000258770, ENST00000361278, 
ENST00000395655, ENST00000494076, 
ENST00000471142, 
ENST00000298310, 
ENST00000382135, ENST00000545773, 
ENST00000556925, ENST00000546046, 
ENST00000556672, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 11 X 2=176
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/176*10)=-0.437063805608843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBRG4 [Title/Abstract] AND NEMF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU532331TBRG4chr7

45148641

-NEMFchr14

50050356

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000258770ENST00000298310TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000258770ENST00000382135TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000258770ENST00000545773TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000258770ENST00000556925TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000258770ENST00000546046TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000258770ENST00000556672TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000361278ENST00000298310TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000361278ENST00000382135TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000361278ENST00000545773TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000361278ENST00000556925TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000361278ENST00000546046TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000361278ENST00000556672TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000395655ENST00000298310TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000395655ENST00000382135TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000395655ENST00000545773TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000395655ENST00000556925TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000395655ENST00000546046TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000395655ENST00000556672TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000494076ENST00000298310TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000494076ENST00000382135TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000494076ENST00000545773TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000494076ENST00000556925TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000494076ENST00000546046TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000494076ENST00000556672TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000471142ENST00000298310TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000471142ENST00000382135TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000471142ENST00000545773TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000471142ENST00000556925TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000471142ENST00000546046TBRG4chr7

45148641

-NEMFchr14

50050356

-
intron-intronENST00000471142ENST00000556672TBRG4chr7

45148641

-NEMFchr14

50050356

-

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FusionProtFeatures for TBRG4_NEMF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBRG4

Q969Z0

NEMF

O60524


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBRG4_NEMF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBRG4_NEMF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBRG4_NEMF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBRG4_NEMF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource