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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37504

FusionGeneSummary for TBRG1_TBRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBRG1_TBRG1
Fusion gene ID: 37504
HgeneTgene
Gene symbol

TBRG1

TBRG1

Gene ID

84897

84897

Gene nametransforming growth factor beta regulator 1transforming growth factor beta regulator 1
SynonymsNIAM|TB-5NIAM|TB-5
Cytomap

11q24.2

11q24.2

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor beta regulator 1nuclear interactor of ARF and MDM2transforming growth factor beta regulator 1nuclear interactor of ARF and MDM2
Modification date2018051920180519
UniProtAcc

Q3YBR2

Q3YBR2

Ensembl transtripts involved in fusion geneENST00000441174, ENST00000375005, 
ENST00000438907, 
ENST00000441174, 
ENST00000375005, ENST00000438907, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: TBRG1 [Title/Abstract] AND TBRG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBRG1

GO:1990173

protein localization to nucleoplasm

17110379

TgeneTBRG1

GO:1990173

protein localization to nucleoplasm

17110379


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI963686TBRG1chr11

124493912

-TBRG1chr11

124493621

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000441174ENST00000441174TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000441174ENST00000375005TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000441174ENST00000438907TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000375005ENST00000441174TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000375005ENST00000375005TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000375005ENST00000438907TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000438907ENST00000441174TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000438907ENST00000375005TBRG1chr11

124493912

-TBRG1chr11

124493621

+
intron-intronENST00000438907ENST00000438907TBRG1chr11

124493912

-TBRG1chr11

124493621

+

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FusionProtFeatures for TBRG1_TBRG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBRG1

Q3YBR2

TBRG1

Q3YBR2

Acts as a growth inhibitor. Can activate p53/TP53,causes G1 arrest and collaborates with CDKN2A to restrictproliferation, but does not require either protein to inhibit DNAsynthesis. Redistributes CDKN2A into the nucleoplasm. Involved inmaintaining chromosomal stability. {ECO:0000269|PubMed:17110379}. Acts as a growth inhibitor. Can activate p53/TP53,causes G1 arrest and collaborates with CDKN2A to restrictproliferation, but does not require either protein to inhibit DNAsynthesis. Redistributes CDKN2A into the nucleoplasm. Involved inmaintaining chromosomal stability. {ECO:0000269|PubMed:17110379}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBRG1_TBRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBRG1_TBRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBRG1_TBRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBRG1_TBRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource