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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3750

FusionGeneSummary for B4GALT5_PTGIS

check button Fusion gene summary
Fusion gene informationFusion gene name: B4GALT5_PTGIS
Fusion gene ID: 3750
HgeneTgene
Gene symbol

B4GALT5

PTGIS

Gene ID

9334

5740

Gene namebeta-1,4-galactosyltransferase 5prostaglandin I2 synthase
SynonymsB4Gal-T5|BETA4-GALT-IV|beta4Gal-T5|beta4GalT-V|gt-VCYP8|CYP8A1|PGIS|PTGI
Cytomap

20q13.13

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-galactosyltransferase 5UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5beta-1,4-GalT IIbeta-1,4-GalT Iprostacyclin synthasecytochrome P450, family 8, subfamily A, polypeptide 1prostaglandin I2 (prostacyclin) synthase
Modification date2018052220180523
UniProtAcc

O43286

Q16647

Ensembl transtripts involved in fusion geneENST00000371711, ENST00000244043, 
ENST00000478971, 
Fusion gene scores* DoF score14 X 9 X 9=11344 X 3 X 3=36
# samples 144
** MAII scorelog2(14/1134*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: B4GALT5 [Title/Abstract] AND PTGIS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTGIS

GO:0001516

prostaglandin biosynthetic process

20122998|21296955

TgenePTGIS

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20159982

TgenePTGIS

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

11551955

TgenePTGIS

GO:0045019

negative regulation of nitric oxide biosynthetic process

20159982

TgenePTGIS

GO:0050728

negative regulation of inflammatory response

20159982

TgenePTGIS

GO:0071456

cellular response to hypoxia

21296955

TgenePTGIS

GO:0097190

apoptotic signaling pathway

11551955

TgenePTGIS

GO:1900119

positive regulation of execution phase of apoptosis

11551955


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AM-01AB4GALT5chr20

48330113

-PTGISchr20

48166726

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371711ENST00000244043B4GALT5chr20

48330113

-PTGISchr20

48166726

-
5CDS-5UTRENST00000371711ENST00000478971B4GALT5chr20

48330113

-PTGISchr20

48166726

-

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FusionProtFeatures for B4GALT5_PTGIS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B4GALT5

O43286

PTGIS

Q16647

Responsible for the synthesis of complex-type N-linkedoligosaccharides in many glycoproteins as well as the carbohydratemoieties of glycolipids. {ECO:0000269|PubMed:9435216}. Catalyzes the isomerization of prostaglandin H2 toprostacyclin (= prostaglandin I2). {ECO:0000269|PubMed:18032380,ECO:0000269|PubMed:25623425}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for B4GALT5_PTGIS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for B4GALT5_PTGIS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B4GALT5ELAVL1, HLA-DPA1, NXPH2, IL20RB, GINM1, TNF, LIPH, IL27RA, FCGRT, SLC39A9, KIAA1467, IL13RA2, SYT12, KERA, GABRG2, CRP, HSPA13, MGAT4C, AVP, TPCN2, TRIM25PTGISAPP, PTGS2, PTGS1, CAV1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B4GALT5_PTGIS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePTGISQ16647DB01240EpoprostenolProstacyclin synthasesmall moleculeapproved
TgenePTGISQ16647DB00812PhenylbutazoneProstacyclin synthasesmall moleculeapproved|vet_approved

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RelatedDiseases for B4GALT5_PTGIS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneB4GALT5C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneB4GALT5C3495559Juvenile arthritis1CTD_human
TgenePTGISC0000786Spontaneous abortion1CTD_human
TgenePTGISC0013274Patent ductus arteriosus1CTD_human
TgenePTGISC0024121Lung Neoplasms1CTD_human
TgenePTGISC0038325Stevens-Johnson Syndrome1CTD_human