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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37489

FusionGeneSummary for TBL1XR1_ROCK1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBL1XR1_ROCK1
Fusion gene ID: 37489
HgeneTgene
Gene symbol

TBL1XR1

ROCK1

Gene ID

79718

6093

Gene nametransducin beta like 1 X-linked receptor 1Rho associated coiled-coil containing protein kinase 1
SynonymsC21|DC42|IRA1|MRD41|TBLR1P160ROCK|ROCK-I
Cytomap

3q26.32

18q11.1

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1XR1TBL1-related protein 1nuclear receptor co-repressor/HDAC3 complex subunitnuclear receptor corepressor/HDAC3 complex subunit TBLR1rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35
Modification date2018052320180527
UniProtAcc

Q9BZK7

Q13464

Ensembl transtripts involved in fusion geneENST00000430069, ENST00000457928, 
ENST00000399799, 
Fusion gene scores* DoF score24 X 9 X 12=25922 X 2 X 2=8
# samples 242
** MAII scorelog2(24/2592*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TBL1XR1 [Title/Abstract] AND ROCK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBL1XR1

GO:0000122

negative regulation of transcription by RNA polymerase II

12628926

HgeneTBL1XR1

GO:0045893

positive regulation of transcription, DNA-templated

18193033

HgeneTBL1XR1

GO:0045944

positive regulation of transcription by RNA polymerase II

18193033

TgeneROCK1

GO:0007159

leukocyte cell-cell adhesion

12082081

TgeneROCK1

GO:0022614

membrane to membrane docking

12082081

TgeneROCK1

GO:0032091

negative regulation of protein binding

18573880

TgeneROCK1

GO:0032956

regulation of actin cytoskeleton organization

25911094

TgeneROCK1

GO:0050900

leukocyte migration

12082081

TgeneROCK1

GO:0050901

leukocyte tethering or rolling

12082081


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-7901-01ATBL1XR1chr3

176914909

-ROCK1chr18

18619524

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000430069ENST00000399799TBL1XR1chr3

176914909

-ROCK1chr18

18619524

-
5UTR-3CDSENST00000457928ENST00000399799TBL1XR1chr3

176914909

-ROCK1chr18

18619524

-

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FusionProtFeatures for TBL1XR1_ROCK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBL1XR1

Q9BZK7

ROCK1

Q13464

F-box-like protein involved in the recruitment of theubiquitin/19S proteasome complex to nuclear receptor-regulatedtranscription units. Plays an essential role in transcriptionactivation mediated by nuclear receptors. Probably acts asintegral component of the N-Cor corepressor complex that mediatesthe recruitment of the 19S proteasome complex, leading to thesubsequent proteasomal degradation of N-Cor complex, therebyallowing cofactor exchange, and transcription activation.{ECO:0000269|PubMed:14980219}. Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBL1XR1_ROCK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBL1XR1_ROCK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBL1XR1NCOR1, HIST2H4A, HIST2H2BE, HDAC3, TBL1X, SKI, UBE2E3, EMD, THRA, THRB, BCL3, HDAC5, PSMA3, SOX2, ELAVL1, UBE2D1, CTNNB1, TAB2, AR, ESR1, RARA, CHD4, CD2BP2, NOTCH1, KDM1A, GPS2, HDAC1, HDAC4, HDAC7, ABCF1, IRS4, ARL2, RNF2, SIRT6, QPRT, FKBP6, TTC29, TSC22D4, ACTL6A, EIF2A, NHP2L1, PPIF, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCD2, SMARCD3, NTRK1, NINL, XPO1, FOXK1, FOXK2, UBE2I, TBL1Y, NCAPH2, MKX, IL17RA, HAO2, USP44, TRIM25ROCK1CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBL1XR1_ROCK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBL1XR1_ROCK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBL1XR1C0345967Malignant mesothelioma1CTD_human
HgeneTBL1XR1C1865644Plantar Lipomatosis, Unusual Facies, and Developmental Delay1UNIPROT