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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37400

FusionGeneSummary for TBC1D31_ZNF704

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D31_ZNF704
Fusion gene ID: 37400
HgeneTgene
Gene symbol

TBC1D31

ZNF704

Gene ID

93594

619279

Gene nameTBC1 domain family member 31zinc finger protein 704
SynonymsGm85|WDR67Gig1
Cytomap

8q24.13

8q21.13

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 31WD repeat domain 67WD repeat-containing protein 67zinc finger protein 704
Modification date2018052320180519
UniProtAcc

Q96DN5

Q6ZNC4

Ensembl transtripts involved in fusion geneENST00000287380, ENST00000309336, 
ENST00000327098, ENST00000522420, 
ENST00000521676, ENST00000378080, 
ENST00000518805, 
ENST00000327835, 
ENST00000520336, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 4=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D31 [Title/Abstract] AND ZNF704 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1XX000017TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000287380ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-intronENST00000287380ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-5UTRENST00000309336ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-intronENST00000309336ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-5UTRENST00000327098ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-intronENST00000327098ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-5UTRENST00000522420ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-intronENST00000522420ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-5UTRENST00000521676ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-intronENST00000521676ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-5UTRENST00000378080ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
5CDS-intronENST00000378080ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
intron-5UTRENST00000518805ENST00000327835TBC1D31chr8

124096582

+ZNF704chr8

81733852

-
intron-intronENST00000518805ENST00000520336TBC1D31chr8

124096582

+ZNF704chr8

81733852

-

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FusionProtFeatures for TBC1D31_ZNF704


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D31

Q96DN5

ZNF704

Q6ZNC4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBC1D31_ZNF704


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D31_ZNF704


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBC1D31LTBR, MED4, CEP162, SSX2IP, PCM1, KIAA0753, CEP290, CEP120, SPICE1, CEP128, CEP135, CEP63, CEP89, CNTRL, ODF2, LCA5, MYH11, OFD1, FGFR1OP, MAPRE1, CCDC14, KIF7, CDC14A, PTPN22, TPTE2, WDR34, IL22RA2ZNF704FBXW11, BTRC, SAP30L, SIN3A, SUDS3, ING2, ARID4A, SAP30, SAP130, ARID4B, BRMS1L, FBXW5, BRMS1, TPM2, CUL1, DCP1B, IMPDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D31_ZNF704


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D31_ZNF704


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource