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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37397

FusionGeneSummary for TBC1D2B_YIPF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D2B_YIPF1
Fusion gene ID: 37397
HgeneTgene
Gene symbol

TBC1D2B

YIPF1

Gene ID

23102

54432

Gene nameTBC1 domain family member 2BYip1 domain family member 1
Synonyms-DJ167A19.1|FinGER1
Cytomap

15q24.3-q25.1

1p32.3

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 2Bprotein YIPF1YIP1 family member 1
Modification date2018052320180523
UniProtAcc

Q9UPU7

Q9Y548

Ensembl transtripts involved in fusion geneENST00000300584, ENST00000409931, 
ENST00000492078, 
ENST00000371399, 
ENST00000072644, ENST00000539954, 
ENST00000469457, 
Fusion gene scores* DoF score7 X 8 X 5=2803 X 2 X 3=18
# samples 129
** MAII scorelog2(12/280*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/18*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TBC1D2B [Title/Abstract] AND YIPF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC094812TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
ChiTaRS3.1BM043998TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
ChiTaRS3.1BM047840TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
ChiTaRS3.1BM047092TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
ChiTaRS3.1BQ937210TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
ChiTaRS3.1BQ930999TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000300584ENST00000371399TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000300584ENST00000072644TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000300584ENST00000539954TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-5UTRENST00000300584ENST00000469457TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000409931ENST00000371399TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000409931ENST00000072644TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000409931ENST00000539954TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-5UTRENST00000409931ENST00000469457TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000492078ENST00000371399TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000492078ENST00000072644TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-3CDSENST00000492078ENST00000539954TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-
intron-5UTRENST00000492078ENST00000469457TBC1D2Bchr15

78309023

-YIPF1chr1

54331905

-

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FusionProtFeatures for TBC1D2B_YIPF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D2B

Q9UPU7

YIPF1

Q9Y548

May act as a GTPase-activating protein. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBC1D2B_YIPF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D2B_YIPF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D2B_YIPF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D2B_YIPF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource