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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3738

FusionGeneSummary for B4GALT3_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: B4GALT3_BCAS3
Fusion gene ID: 3738
HgeneTgene
Gene symbol

B4GALT3

BCAS3

Gene ID

8703

54828

Gene namebeta-1,4-galactosyltransferase 3BCAS3, microtubule associated cell migration factor
Synonymsbeta4Gal-T3GAOB1|MAAB
Cytomap

1q23.3

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-galactosyltransferase 3UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3b4Gal-T3beta-1,4-GalTase 3betbreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018051920180523
UniProtAcc

O60512

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000319769, ENST00000470882, 
ENST00000367998, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score2 X 2 X 2=826 X 15 X 15=5850
# samples 241
** MAII scorelog2(2/8*10)=1.32192809488736log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B4GALT3 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneB4GALT3

GO:0006682

galactosylceramide biosynthetic process

9405390

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-8511-01AB4GALT3chr1

161147213

-BCAS3chr17

59161828

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000319769ENST00000589222B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000319769ENST00000407086B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000319769ENST00000390652B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000319769ENST00000408905B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000319769ENST00000588462B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000319769ENST00000585744B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000319769ENST00000588874B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-intronENST00000319769ENST00000585812B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000589222B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000407086B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000390652B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000408905B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000588462B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000585744B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-3CDSENST00000470882ENST00000588874B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
intron-intronENST00000470882ENST00000585812B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000589222B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000407086B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000390652B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000408905B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000588462B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000585744B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-3CDSENST00000367998ENST00000588874B4GALT3chr1

161147213

-BCAS3chr17

59161828

+
5UTR-intronENST00000367998ENST00000585812B4GALT3chr1

161147213

-BCAS3chr17

59161828

+

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FusionProtFeatures for B4GALT3_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B4GALT3

O60512

BCAS3

Q9H6U6

Responsible for the synthesis of complex-type N-linkedoligosaccharides in many glycoproteins as well as the carbohydratemoieties of glycolipids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for B4GALT3_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for B4GALT3_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B4GALT3ARL15, SAT1, FBXO6, HLA-DPA1, POMK, ATP5B, GHITM, XYLT2, POMGNT1, ZDHHC17, ATP5F1, PON2, ATP5G1, REEP4, GPR89B, UBE4A, LMF1, ASPHD2, GOLGA5, FAM8A1, TMEM120A, TMEM205, PTCH1, LPAR1, ANP32A, GALNT6, SLC19A2, CRP, CGRRF1, ATP6V0A2, IL13RA2, TRIM25BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B4GALT3_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for B4GALT3_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource