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Fusion gene ID: 37369 |
FusionGeneSummary for TBC1D22A_GTSE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D22A_GTSE1 | Fusion gene ID: 37369 | Hgene | Tgene | Gene symbol | TBC1D22A | GTSE1 | Gene ID | 25771 | 51512 |
| Gene name | TBC1 domain family member 22A | G2 and S-phase expressed 1 | |
| Synonyms | C22orf4|HSC79E021 | B99 | |
| Cytomap | 22q13.31 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 22Aputative GTPase activator | G2 and S phase-expressed protein 1G-2 and S-phase expressed 1protein B99 homolog | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8WUA7 | Q9NYZ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000337137, ENST00000380995, ENST00000407381, ENST00000355704, ENST00000472791, ENST00000406733, | ENST00000454366, | |
| Fusion gene scores | * DoF score | 18 X 10 X 12=2160 | 7 X 6 X 7=294 |
| # samples | 19 | 9 | |
| ** MAII score | log2(19/2160*10)=-3.50695998871988 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TBC1D22A [Title/Abstract] AND GTSE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-4366-01A | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| TCGA | RV | UCEC | TCGA-B5-A1MS-01B | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000337137 | ENST00000454366 | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| 5UTR-3CDS | ENST00000380995 | ENST00000454366 | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| In-frame | ENST00000407381 | ENST00000454366 | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| In-frame | ENST00000355704 | ENST00000454366 | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| intron-3CDS | ENST00000472791 | ENST00000454366 | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| intron-3CDS | ENST00000406733 | ENST00000454366 | TBC1D22A | chr22 | 47158745 | + | GTSE1 | chr22 | 46722333 | + |
| Frame-shift | ENST00000337137 | ENST00000454366 | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
| intron-3CDS | ENST00000380995 | ENST00000454366 | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
| Frame-shift | ENST00000407381 | ENST00000454366 | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
| Frame-shift | ENST00000355704 | ENST00000454366 | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
| intron-3CDS | ENST00000472791 | ENST00000454366 | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
| Frame-shift | ENST00000406733 | ENST00000454366 | TBC1D22A | chr22 | 47433094 | + | GTSE1 | chr22 | 46704047 | + |
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FusionProtFeatures for TBC1D22A_GTSE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBC1D22A | GTSE1 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBC1D22A | chr22:47158745 | chr22:46722333 | ENST00000337137 | + | 1 | 13 | 222_446 | 20 | 518 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D22A | chr22:47158745 | chr22:46722333 | ENST00000355704 | + | 1 | 11 | 222_446 | 20 | 440 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D22A | chr22:47158745 | chr22:46722333 | ENST00000380995 | + | 1 | 9 | 222_446 | -27 | 325 | Domain | Rab-GAP TBC |
| Tgene | GTSE1 | chr22:47158745 | chr22:46722333 | ENST00000454366 | + | 7 | 12 | 22_27 | 501 | 740 | Compositional bias | Note=Poly-Ser |
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FusionGeneSequence for TBC1D22A_GTSE1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBC1D22A_ENST00000337137_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_259aa MASDGARKQFWKRSNSKLPGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKN SAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAAS >In-frame_TBC1D22A_ENST00000407381_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_259aa MASDGARKQFWKRSNSKLPGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKN SAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAAS >In-frame_TBC1D22A_ENST00000355704_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_259aa MASDGARKQFWKRSNSKLPGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKN SAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAAS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBC1D22A_ENST00000337137_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_777nt ATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGGGTCACTGTCCACAGCACCCCGGTTAGA CGCTCATCTGGGCCAGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCGGCGCTGCTCTGGCCTT CCACCGATGACCCCCAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTCTGAGCCCCGCAAGAAC TCTGCAATGAGAACTGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGACAGGGGTTCTCCTCCT TCCCGTGTGCCTCAGGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGAAGTAGCTCGGGAGGAA GCCAAGCCGGGTGGAGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCACTCCAGATGCTGCAAGC CAGCCCCTCATTGACCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAGCAGGCCTCTGATCGAC CTCATGACAAACACTCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCTGAGCTCCCCTCTGATC >In-frame_TBC1D22A_ENST00000407381_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_777nt ATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGGGTCACTGTCCACAGCACCCCGGTTAGA CGCTCATCTGGGCCAGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCGGCGCTGCTCTGGCCTT CCACCGATGACCCCCAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTCTGAGCCCCGCAAGAAC TCTGCAATGAGAACTGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGACAGGGGTTCTCCTCCT TCCCGTGTGCCTCAGGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGAAGTAGCTCGGGAGGAA GCCAAGCCGGGTGGAGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCACTCCAGATGCTGCAAGC CAGCCCCTCATTGACCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAGCAGGCCTCTGATCGAC CTCATGACAAACACTCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCTGAGCTCCCCTCTGATC >In-frame_TBC1D22A_ENST00000355704_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_777nt ATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGGGTCACTGTCCACAGCACCCCGGTTAGA CGCTCATCTGGGCCAGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCGGCGCTGCTCTGGCCTT CCACCGATGACCCCCAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTCTGAGCCCCGCAAGAAC TCTGCAATGAGAACTGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGACAGGGGTTCTCCTCCT TCCCGTGTGCCTCAGGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGAAGTAGCTCGGGAGGAA GCCAAGCCGGGTGGAGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCACTCCAGATGCTGCAAGC CAGCCCCTCATTGACCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAGCAGGCCTCTGATCGAC CTCATGACAAACACTCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCTGAGCTCCCCTCTGATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBC1D22A_ENST00000337137_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_1623nt GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGGGTCACTGTCCACAGCACCCCGGTTAGACGCTCATCTGGGCC AGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCGGCGCTGCTCTGGCCTTCCACCGATGACCCC CAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTCTGAGCCCCGCAAGAACTCTGCAATGAGAAC TGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGACAGGGGTTCTCCTCCTTCCCGTGTGCCTCA GGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGAAGTAGCTCGGGAGGAAGCCAAGCCGGGTGG AGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCACTCCAGATGCTGCAAGCCAGCCCCTCATTGA CCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAGCAGGCCTCTGATCGACCTCATGACAAACAC TCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCTGAGCTCCCCTCTGATCCAGCTGAGCCCTGA GGCTGACAAGGAGAACGTGGATTCCCCACTCCTCAAGTTCTAAGCCGAACCAAATCCTTTGCCTTGAAAGAACAGCCCTAAAGTGGTTTT CAACCCTCAGAAACAAGCTTTAGGCTGGTCGCAGTGGCTTACACTTGTAACCCTAGAACTTGGGAGGCTGAGGTGGGCGGATTACTTGAG CCCAGGAGTTCGGGACCAGCCTGGGAAATATAGTGAAACTCCTGTCCCTACAAAAAATACAAAAATTAGCCGGGTGTGGTAGTGCATGCC TGTAGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGGATGGCCTGAGCTCAAGGAGATGCAGGCTGCAGTGGGCTGTGATTGTGCCACTGC ACTCCAGCCTGGGCACCAATGTGAGAACCTGTCTTGGAAAAAAAAAAAAAGAAACATGTTTTAGTAGAAGTTTTATTTGAAAAAGAAAAA TAAGCATAAATATATTCCCAGTGCTGGAGAGGGTGGGCTGAGGGACTGGGGCCAGCACGGACCACCCAAGGCCTCTGCTTCCCGCCGCCA CCCTCCTCGCTGCCATTCTCTGGGCTGGAATGTGAAGCCTCAGTCACTCTAAATGAAGAATTTTCTTTTGAATGTTTTGTATGTAAAATA GCAAGTGGCTATTTTTAAAGTTAAGTTTGTATAAATAGTTAGATATTCTAGATTTACATTAAATTGTAAAATAAATGGACTTATTGAAGC >In-frame_TBC1D22A_ENST00000407381_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_1572nt CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGGGT CACTGTCCACAGCACCCCGGTTAGACGCTCATCTGGGCCAGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACC CGCCAGCCGGCGCTGCTCTGGCCTTCCACCGATGACCCCCAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAG ACGTTCCTCTGAGCCCCGCAAGAACTCTGCAATGAGAACTGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGT GTCCCCTGACAGGGGTTCTCCTCCTTCCCGTGTGCCTCAGGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTAC TGCCACAGAAGTAGCTCGGGAGGAAGCCAAGCCGGGTGGAGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACT CGCGGTCACTCCAGATGCTGCAAGCCAGCCCCTCATTGACCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGG ATCTGAAAGCAGGCCTCTGATCGACCTCATGACAAACACTCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCT CATAGACCTGAGCTCCCCTCTGATCCAGCTGAGCCCTGAGGCTGACAAGGAGAACGTGGATTCCCCACTCCTCAAGTTCTAAGCCGAACC AAATCCTTTGCCTTGAAAGAACAGCCCTAAAGTGGTTTTCAACCCTCAGAAACAAGCTTTAGGCTGGTCGCAGTGGCTTACACTTGTAAC CCTAGAACTTGGGAGGCTGAGGTGGGCGGATTACTTGAGCCCAGGAGTTCGGGACCAGCCTGGGAAATATAGTGAAACTCCTGTCCCTAC AAAAAATACAAAAATTAGCCGGGTGTGGTAGTGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGGATGGCCTGAGCTCAA GGAGATGCAGGCTGCAGTGGGCTGTGATTGTGCCACTGCACTCCAGCCTGGGCACCAATGTGAGAACCTGTCTTGGAAAAAAAAAAAAAG AAACATGTTTTAGTAGAAGTTTTATTTGAAAAAGAAAAATAAGCATAAATATATTCCCAGTGCTGGAGAGGGTGGGCTGAGGGACTGGGG CCAGCACGGACCACCCAAGGCCTCTGCTTCCCGCCGCCACCCTCCTCGCTGCCATTCTCTGGGCTGGAATGTGAAGCCTCAGTCACTCTA AATGAAGAATTTTCTTTTGAATGTTTTGTATGTAAAATAGCAAGTGGCTATTTTTAAAGTTAAGTTTGTATAAATAGTTAGATATTCTAG >In-frame_TBC1D22A_ENST00000355704_chr22_47158745_+_GTSE1_ENST00000454366_chr22_46722333_+_1563nt CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGGGTCACTGTCCA CAGCACCCCGGTTAGACGCTCATCTGGGCCAGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCG GCGCTGCTCTGGCCTTCCACCGATGACCCCCAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTC TGAGCCCCGCAAGAACTCTGCAATGAGAACTGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGA CAGGGGTTCTCCTCCTTCCCGTGTGCCTCAGGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGA AGTAGCTCGGGAGGAAGCCAAGCCGGGTGGAGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCAC TCCAGATGCTGCAAGCCAGCCCCTCATTGACCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAG CAGGCCTCTGATCGACCTCATGACAAACACTCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCT GAGCTCCCCTCTGATCCAGCTGAGCCCTGAGGCTGACAAGGAGAACGTGGATTCCCCACTCCTCAAGTTCTAAGCCGAACCAAATCCTTT GCCTTGAAAGAACAGCCCTAAAGTGGTTTTCAACCCTCAGAAACAAGCTTTAGGCTGGTCGCAGTGGCTTACACTTGTAACCCTAGAACT TGGGAGGCTGAGGTGGGCGGATTACTTGAGCCCAGGAGTTCGGGACCAGCCTGGGAAATATAGTGAAACTCCTGTCCCTACAAAAAATAC AAAAATTAGCCGGGTGTGGTAGTGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGGATGGCCTGAGCTCAAGGAGATGCA GGCTGCAGTGGGCTGTGATTGTGCCACTGCACTCCAGCCTGGGCACCAATGTGAGAACCTGTCTTGGAAAAAAAAAAAAAGAAACATGTT TTAGTAGAAGTTTTATTTGAAAAAGAAAAATAAGCATAAATATATTCCCAGTGCTGGAGAGGGTGGGCTGAGGGACTGGGGCCAGCACGG ACCACCCAAGGCCTCTGCTTCCCGCCGCCACCCTCCTCGCTGCCATTCTCTGGGCTGGAATGTGAAGCCTCAGTCACTCTAAATGAAGAA TTTTCTTTTGAATGTTTTGTATGTAAAATAGCAAGTGGCTATTTTTAAAGTTAAGTTTGTATAAATAGTTAGATATTCTAGATTTACATT |
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FusionGenePPI for TBC1D22A_GTSE1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBC1D22A | YWHAB, HSPA1L, ACBD3, FDXR, ACSL4, FLYWCH2, BIRC6, ARFGEF1, QSOX2, MICU1, KIRREL, MICU2, DNAJB4, SUPT6H, EFNB3, EPHA4, EXOG, METTL13, PVRL2, DNAJB5, AMBRA1, CERK, TBC1D22B | GTSE1 | USP11, SH3KBP1, BARD1, HNRNPD, CCDC8, KPTN, KIAA0753, CEP170, SPICE1, CNTRL, NINL, DCTN1, LCA5, POC1A, XPO1, AP2A1, AP2A2, AP1B1, AP2B1, AP1G1, CALU, CDC42, AP2M1, AP1S1, CLTA, CLTB, CLTC, CSNK1A1, CSNK1E, DAB2, EPS15, GAK, GNAI3, GOLGA2, HIP1, IGF2R, NBR1, MYO6, NDUFA9, OCRL, PER1, PIK3C2A, PKP2, RAB1A, RCN1, SEC13, RAB7A, CLTCL1, PICALM, PKP4, USO1, NUMB, TNK1, SYNJ1, AP1M1, HERC2, HIP1R, NUMBL, SEC24C, KIAA0430, CLINT1, SEC16A, MVP, TNK2, DCAF7, SEC24B, RBM14, SEC23A, VTI1B, STAMBP, SEC24A, SDCCAG3, RALBP1, PKP3, SYNRG, AAK1, BTBD3, EPN2, TNRC6B, N4BP3, DNMBP, EDC4, NECAP1, PHGDH, TNRC6A, PPP2R3B, EPN1, SNX9, LIMA1, CAPZA2, DBN1, MYH9, IQGAP1, THOC1, ANLN, MYO19, ARX, BOD1L1, DNAJB11, BMP2K, SCYL2, ERBB2IP, KIDINS220, STAMBPL1, DENND1A, ZNF106, SMAP2, CRTC3, WNK1, ACAD11, LZTS2, MYPN, REPS1, STON2, FCHO2, FAM109B, CRTC2, FAM83B, FAM83H, FAM21A, PRKACA, FOXJ2, GAST, CAV3, XAGE3, PPP2R3A, DDB2, IL17RA, NCAPH2, P4HA2, KBTBD7, CARM1, C6orf141, CDC16 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D22A_GTSE1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D22A_GTSE1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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