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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37367

FusionGeneSummary for TBC1D22A_GRAMD4

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D22A_GRAMD4
Fusion gene ID: 37367
HgeneTgene
Gene symbol

TBC1D22A

GRAMD4

Gene ID

25771

23151

Gene nameTBC1 domain family member 22AGRAM domain containing 4
SynonymsC22orf4|HSC79E021DIP|dA59H18.1|dJ439F8.1
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 22Aputative GTPase activatorGRAM domain-containing protein 4death-inducing-protein
Modification date2018052320180519
UniProtAcc

Q8WUA7

Q6IC98

Ensembl transtripts involved in fusion geneENST00000337137, ENST00000380995, 
ENST00000407381, ENST00000355704, 
ENST00000472791, ENST00000406733, 
ENST00000406902, ENST00000361034, 
ENST00000490378, ENST00000408031, 
Fusion gene scores* DoF score18 X 10 X 12=21605 X 3 X 4=60
# samples 194
** MAII scorelog2(19/2160*10)=-3.50695998871988
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D22A [Title/Abstract] AND GRAMD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A24H-01ATBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
TCGARVLIHCTCGA-WJ-A86L-01ATBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337137ENST00000406902TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000337137ENST00000361034TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000337137ENST00000490378TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000337137ENST00000408031TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000380995ENST00000406902TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000380995ENST00000361034TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000380995ENST00000490378TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000380995ENST00000408031TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-5UTRENST00000407381ENST00000406902TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000407381ENST00000361034TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000407381ENST00000490378TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000407381ENST00000408031TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-5UTRENST00000355704ENST00000406902TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000355704ENST00000361034TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000355704ENST00000490378TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000355704ENST00000408031TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-5UTRENST00000472791ENST00000406902TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000472791ENST00000361034TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000472791ENST00000490378TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
intron-intronENST00000472791ENST00000408031TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000406733ENST00000406902TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000406733ENST00000361034TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000406733ENST00000490378TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-intronENST00000406733ENST00000408031TBC1D22Achr22

47193517

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000337137ENST00000406902TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000337137ENST00000361034TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000337137ENST00000490378TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000337137ENST00000408031TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000380995ENST00000406902TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000380995ENST00000361034TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000380995ENST00000490378TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000380995ENST00000408031TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000407381ENST00000406902TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000407381ENST00000361034TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000407381ENST00000490378TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000407381ENST00000408031TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000355704ENST00000406902TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000355704ENST00000361034TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000355704ENST00000490378TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000355704ENST00000408031TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
intron-5UTRENST00000472791ENST00000406902TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
intron-intronENST00000472791ENST00000361034TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
intron-intronENST00000472791ENST00000490378TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
intron-intronENST00000472791ENST00000408031TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-5UTRENST00000406733ENST00000406902TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000406733ENST00000361034TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000406733ENST00000490378TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+
5CDS-intronENST00000406733ENST00000408031TBC1D22Achr22

47308084

+GRAMD4chr22

47022648

+

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FusionProtFeatures for TBC1D22A_GRAMD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D22A

Q8WUA7

GRAMD4

Q6IC98

Plays a role as a mediator of E2F1-induced apoptosis inthe absence of p53/TP53. {ECO:0000269|PubMed:15565177}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBC1D22A_GRAMD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D22A_GRAMD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBC1D22AYWHAB, HSPA1L, ACBD3, FDXR, ACSL4, FLYWCH2, BIRC6, ARFGEF1, QSOX2, MICU1, KIRREL, MICU2, DNAJB4, SUPT6H, EFNB3, EPHA4, EXOG, METTL13, PVRL2, DNAJB5, AMBRA1, CERK, TBC1D22BGRAMD4APP, RBL2, TBC1D15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D22A_GRAMD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D22A_GRAMD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource