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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37360

FusionGeneSummary for TBC1D20_FN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D20_FN1
Fusion gene ID: 37360
HgeneTgene
Gene symbol

TBC1D20

FN1

Gene ID

128637

2335

Gene nameTBC1 domain family member 20fibronectin 1
SynonymsC20orf140|WARBM4CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF
Cytomap

20p13

2q35

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 20fibronectincold-insoluble globulinmigration-stimulating factor
Modification date2018052320180527
UniProtAcc

Q96BZ9

P02751

Ensembl transtripts involved in fusion geneENST00000461188, ENST00000354200, 
ENST00000421182, ENST00000357867, 
ENST00000323926, ENST00000336916, 
ENST00000354785, ENST00000357009, 
ENST00000346544, ENST00000345488, 
ENST00000359671, ENST00000446046, 
ENST00000443816, ENST00000432072, 
ENST00000356005, ENST00000490833, 
ENST00000426059, 
Fusion gene scores* DoF score2 X 2 X 3=1220 X 22 X 3=1320
# samples 326
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(26/1320*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D20 [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

TgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

TgeneFN1

GO:0010628

positive regulation of gene expression

25834989

TgeneFN1

GO:0018149

peptide cross-linking

3997886

TgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneFN1

GO:0035987

endodermal cell differentiation

23154389

TgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

TgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

TgeneFN1

GO:0052047

interaction with other organism via secreted substance involved in symbiotic interaction

17849409

TgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

TgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

TgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ008587TBC1D20chr20

417499

+FN1chr2

216230830

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000461188ENST00000421182TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000357867TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000323926TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000336916TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000354785TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000357009TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000346544TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000345488TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000359671TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000446046TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000443816TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000432072TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000356005TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000490833TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000461188ENST00000426059TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000421182TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000357867TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000323926TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000336916TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000354785TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000357009TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000346544TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000345488TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000359671TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000446046TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000443816TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000432072TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000356005TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000490833TBC1D20chr20

417499

+FN1chr2

216230830

+
intron-intronENST00000354200ENST00000426059TBC1D20chr20

417499

+FN1chr2

216230830

+

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FusionProtFeatures for TBC1D20_FN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D20

Q96BZ9

FN1

P02751

GTPase-activating protein specific for Rab1 and Rab2small GTPase families for which it can accelerate the intrinsicGTP hydrolysis rate by more than five orders of magnitude.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBC1D20_FN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D20_FN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D20_FN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFN1P02751DB08888OcriplasminFibronectinbiotechapproved
TgeneFN1P02751DB01593ZincFibronectinsmall moleculeapproved|investigational

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RelatedDiseases for TBC1D20_FN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFN1C0020538Hypertensive disease2CTD_human;HPO
TgeneFN1C0000786Spontaneous abortion1CTD_human
TgeneFN1C0003504Aortic Valve Insufficiency1CTD_human
TgeneFN1C0007621Neoplastic Cell Transformation1CTD_human
TgeneFN1C0010346Crohn Disease1CTD_human
TgeneFN1C0011849Diabetes Mellitus1CTD_human
TgeneFN1C0011881Diabetic Nephropathy1CTD_human
TgeneFN1C0017636Glioblastoma1CTD_human
TgeneFN1C0017668Focal glomerulosclerosis1CTD_human
TgeneFN1C0024667Animal Mammary Neoplasms1CTD_human
TgeneFN1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneFN1C0027626Neoplasm Invasiveness1CTD_human
TgeneFN1C0034069Pulmonary Fibrosis1CTD_human
TgeneFN1C0036341Schizophrenia1PSYGENET
TgeneFN1C0085762Alcohol abuse1PSYGENET
TgeneFN1C0149721Left Ventricular Hypertrophy1CTD_human
TgeneFN1C0345967Malignant mesothelioma1CTD_human
TgeneFN1C1458155Mammary Neoplasms1CTD_human
TgeneFN1C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1UNIPROT