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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 373

FusionGeneSummary for ACER2_C8orf37

check button Fusion gene summary
Fusion gene informationFusion gene name: ACER2_C8orf37
Fusion gene ID: 373
HgeneTgene
Gene symbol

ACER2

C8orf37

Gene ID

340485

157657

Gene namealkaline ceramidase 2chromosome 8 open reading frame 37
SynonymsALKCDase2|ASAH3LBBS21|CORD16|RP64|smalltalk
Cytomap

9p22.1

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionalkaline ceramidase 2alkCDase 2alkaline CDase 2ceramide hydrolasehaCER2protein C8orf37Bardet-Biedl syndrome 21
Modification date2018032920180523
UniProtAcc

Q5QJU3

Q96NL8

Ensembl transtripts involved in fusion geneENST00000380376, ENST00000340967, 
ENST00000286688, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ACER2 [Title/Abstract] AND C8orf37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACER2

GO:0001953

negative regulation of cell-matrix adhesion

18945876

HgeneACER2

GO:0008284

positive regulation of cell proliferation

16940153

HgeneACER2

GO:0032526

response to retinoic acid

18945876

HgeneACER2

GO:0033629

negative regulation of cell adhesion mediated by integrin

18945876

HgeneACER2

GO:0046512

sphingosine biosynthetic process

16940153|20089856|20628055


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-A7NF-01AACER2chr9

19435082

+C8orf37chr8

96276002

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000380376ENST00000286688ACER2chr9

19435082

+C8orf37chr8

96276002

-
In-frameENST00000340967ENST00000286688ACER2chr9

19435082

+C8orf37chr8

96276002

-

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FusionProtFeatures for ACER2_C8orf37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACER2

Q5QJU3

C8orf37

Q96NL8

Hydrolyzes the sphingolipid ceramide into sphingosineand free fatty acid. Unsaturated long-chain ceramides are the bestsubstrates, saturated long-chain ceramides and unsaturated verylong-chain ceramides are good substrates, whereas saturated verylong-chain ceramides and short-chain ceramides were poorsubstrates. The substrate preference is D-erythro-C(18:1)-,C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide> D-erythro-C(6:0)-ceramide. Inhibits the maturation of proteinglycosylation in the Golgi complex, including that of integrinbeta-1 (ITGB1) and of LAMP1, by increasing the levels ofsphingosine. Inhibits cell adhesion by reducing the level of ITGB1in the cell surface. May have a role in cell proliferation andapoptosis that seems to depend on the balance between sphingosineand sphingosine-1-phosphate. {ECO:0000269|PubMed:16940153,ECO:0000269|PubMed:18945876, ECO:0000269|PubMed:20089856}. May be involved in photoreceptor outer segment diskmorphogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UJP5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+461_13167276RegionNote=Essential for localization in the Golgi apparatus and for activity
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+451_13118141RegionNote=Essential for localization in the Golgi apparatus and for activity
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46108_124167276Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46143_143167276Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+461_32167276Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+4654_62167276Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+4684_86167276Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+451_32118141Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+4554_62118141Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+4584_86118141Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46125_142167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46144_164167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+4633_53167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+4663_83167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+4687_107167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+4533_53118141TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+4563_83118141TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+4587_107118141TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46165_173167276Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46195_211167276Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46233_275167276Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45108_124118141Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45143_143118141Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45165_173118141Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45195_211118141Topological domainLumenal
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45233_275118141Topological domainCytoplasmic
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46174_194167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000340967+46212_232167276TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45125_142118141TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45144_164118141TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45174_194118141TransmembraneHelical
HgeneACER2chr9:19435082chr8:96276002ENST00000380376+45212_232118141TransmembraneHelical


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FusionGeneSequence for ACER2_C8orf37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ACER2_ENST00000380376_chr9_19435082_+_C8orf37_ENST00000286688_chr8_96276002_-_275aa
MCLFRQTATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRTLPKIFRNDRGRFKVVVSVLSAVTTCL
AFVKPAINNISLMTLGVPCTALLIAELKRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSS
IPCGIGTNISWRACDHLRCIACDFLVVSTDDTMWDKSCDTLFFRNNMPEFHKLKAKLIKKKGTRATACQCSWRTIEEVTDLQTDHQLRWV

>In-frame_ACER2_ENST00000340967_chr9_19435082_+_C8orf37_ENST00000286688_chr8_96276002_-_324aa
MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQTATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQ
MLDELAVLWVLMCALAMWFPRRTLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRSTETFKKEDDLD
SLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRACDHLRCIACDFLVVSTDDTMWDKSCDTL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ACER2_ENST00000380376_chr9_19435082_+_C8orf37_ENST00000286688_chr8_96276002_-_825nt
ATGTGCTTGTTTCGTCAGTATGCAACATGCTTCAACAGTGGCATCTACTTAATCTGGACTCTTTTGGTTGTAGTGGGAATTGGATCCGTC
TACTTCCATGCAACCCTTAGTTTCTTGGGTCAGATGCTTGATGAACTTGCAGTCCTTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTC
CCCAGAAGGTATCTACCAAAGATCTTTCGGAATGACCGGGGTAGGTTCAAGGTGGTGGTCAGTGTCCTGTCTGCGGTTACGACGTGCCTG
GCATTTGTCAAGCCTGCCATCAACAACATCTCTCTGATGACCCTGGGAGTTCCTTGCACTGCACTGCTCATCGCAGAGCTAAAGAGATCA
ACAGAAACATTTAAAAAAGAAGATGATCTTGACAGTCTTATTAATGAAATACTTGAAGAGCCCAACTTGGACAAAAAACCCTCTAAATTA
AAATCTAAATCTTCAGGTAACACATCTGTCAGAGCTTCCATTGAAGGCCTTGGTAAAAGTTGCAGTCCGGTGTACCTTGGTGGAAGCTCT
ATTCCATGTGGGATTGGAACAAATATTTCATGGAGAGCATGTGACCATCTGCGTTGTATAGCCTGTGATTTCTTGGTAGTCAGCTATGAT
GACTATATGTGGGACAAATCGTGTGATTATCTGTTTTTCAGGAACAACATGCCAGAATTTCACAAATTAAAAGCAAAGTTGATAAAGAAG
AAAGGAACACGGGCATATGCCTGCCAGTGTAGCTGGAGAACTATTGAAGAAGTGACTGACCTTCAGACAGATCATCAGCTTCGCTGGGTT

>In-frame_ACER2_ENST00000340967_chr9_19435082_+_C8orf37_ENST00000286688_chr8_96276002_-_972nt
ATGGGCGCCCCGCACTGGTGGGACCAGCTGCAGGCTGGTAGCTCGGAGGTGGACTGGTGCGAGGACAACTACACCATCGTGCCTGCTATC
GCCGAGTTCTACAACACGATCAGCAATGTCTTATTTTTCATTTTACCGCCCATCTGCATGTGCTTGTTTCGTCAGTATGCAACATGCTTC
AACAGTGGCATCTACTTAATCTGGACTCTTTTGGTTGTAGTGGGAATTGGATCCGTCTACTTCCATGCAACCCTTAGTTTCTTGGGTCAG
ATGCTTGATGAACTTGCAGTCCTTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTCCCCAGAAGGTATCTACCAAAGATCTTTCGGAAT
GACCGGGGTAGGTTCAAGGTGGTGGTCAGTGTCCTGTCTGCGGTTACGACGTGCCTGGCATTTGTCAAGCCTGCCATCAACAACATCTCT
CTGATGACCCTGGGAGTTCCTTGCACTGCACTGCTCATCGCAGAGCTAAAGAGATCAACAGAAACATTTAAAAAAGAAGATGATCTTGAC
AGTCTTATTAATGAAATACTTGAAGAGCCCAACTTGGACAAAAAACCCTCTAAATTAAAATCTAAATCTTCAGGTAACACATCTGTCAGA
GCTTCCATTGAAGGCCTTGGTAAAAGTTGCAGTCCGGTGTACCTTGGTGGAAGCTCTATTCCATGTGGGATTGGAACAAATATTTCATGG
AGAGCATGTGACCATCTGCGTTGTATAGCCTGTGATTTCTTGGTAGTCAGCTATGATGACTATATGTGGGACAAATCGTGTGATTATCTG
TTTTTCAGGAACAACATGCCAGAATTTCACAAATTAAAAGCAAAGTTGATAAAGAAGAAAGGAACACGGGCATATGCCTGCCAGTGTAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ACER2_ENST00000380376_chr9_19435082_+_C8orf37_ENST00000286688_chr8_96276002_-_3828nt
GCGGAGCGCGGGAGGCCAGTTGGGAGGCGCACATCCGGCGGTTACCCGGTGCTTCATAAAGCCGCTTTCGCCGCTGGCTGTCGCCGCGTT
TTGCCTCCGCAGCAGCTCTGGGCTCTTCTCAGCTGCGCGAGCAGCTGCTCCAATGCCCCGGAGTGGCCATGGGCGCCCCGCACTGGTGGG
ACCAGCTGCAGGCTGGTAGCTCGGAGGTGGACTGGTGCGAGGACAACTACACCATCGTGCCTGCTATCGCCGAGTTCTACAACACGATCA
GCAATGTCTTATTTTTCATTTTACCGCCCATCTGCATGTGCTTGTTTCGTCAGTATGCAACATGCTTCAACAGTGGCATCTACTTAATCT
GGACTCTTTTGGTTGTAGTGGGAATTGGATCCGTCTACTTCCATGCAACCCTTAGTTTCTTGGGTCAGATGCTTGATGAACTTGCAGTCC
TTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTCCCCAGAAGGTATCTACCAAAGATCTTTCGGAATGACCGGGGTAGGTTCAAGGTGG
TGGTCAGTGTCCTGTCTGCGGTTACGACGTGCCTGGCATTTGTCAAGCCTGCCATCAACAACATCTCTCTGATGACCCTGGGAGTTCCTT
GCACTGCACTGCTCATCGCAGAGCTAAAGAGATCAACAGAAACATTTAAAAAAGAAGATGATCTTGACAGTCTTATTAATGAAATACTTG
AAGAGCCCAACTTGGACAAAAAACCCTCTAAATTAAAATCTAAATCTTCAGGTAACACATCTGTCAGAGCTTCCATTGAAGGCCTTGGTA
AAAGTTGCAGTCCGGTGTACCTTGGTGGAAGCTCTATTCCATGTGGGATTGGAACAAATATTTCATGGAGAGCATGTGACCATCTGCGTT
GTATAGCCTGTGATTTCTTGGTAGTCAGCTATGATGACTATATGTGGGACAAATCGTGTGATTATCTGTTTTTCAGGAACAACATGCCAG
AATTTCACAAATTAAAAGCAAAGTTGATAAAGAAGAAAGGAACACGGGCATATGCCTGCCAGTGTAGCTGGAGAACTATTGAAGAAGTGA
CTGACCTTCAGACAGATCATCAGCTTCGCTGGGTTTGTGGTAAACATTAAGAATGCAGACTGCACATTCGGACAGATGCATCCATGAGAG
TGGTCTCCATGAATCATCATCATGTTTAGACAATAGTCCCTAGCAATACCATTCCCTGTGGGAAAAGGCAGTGAATTTTATTGATACAAC
TACATACATTTTTGAAGACCAAATGGACTAAGGAAGATCATGTATTATAACACTTTGGAATTATTCCTGATACATGGATGTTTCACTTAG
TAACAGGCATCTACATTCTTTACTAATCTGTCTTCTGTTTAATAGAGGTTTGATTATGGAGTTCCATACAAATATCTAGTTTTTCATTAG
CAACTGCAATATTGATTGCTAATACGTTTAGCAAATCATTCCCCAACTTGTAGCAGTTAAAGTGGATAAAGCCGGCCAGGGCAAAGAGAT
CATTTAGGGGTGTCTACAACACTTCTTCCAGTCAGATCTTTTGTTGCCAAAGATCATAATTTGGACATGGCAGAAACCAGGTGATCAGTG
GCTGACTGAAGGGTGTTCAGAAGTAGTTACAGGTATTTTGCAAAAACACTGCCTCATAGCTGATCTTACCTCATCAACTCAAAGCAATGT
TATGCACAATATTAAATACATGTTACCAGTTTTAGCTTATTTTTCCCTCTTTTGTTCATTTAACTATCAAAAGTTATTTTCTATTTTGAT
TACCCAATAATATATAAAAAGAGTTTGATGCACCCAAAATCACAAAAATCCTAATACATACAGGTTATTGTTGGATTTTCCAAGTACTTT
CTATCCTTTAATGCCTAAAACTCCATCAAGGGAAGTAAACAGCAAGTAATATAATTTTTCAGGCAGCCTGTGGACTTCTCTGGTAGGATC
AGGTTGACATATCGTTTATTAGGTGAGTAAGTGAAAAGACAAGTAAAGCATAACTGAACCAACAGGTAACCTGTTGGGCTCCTTCCTGAC
ATCACTGAGATCTGAGGAGCCCTACAATAGCAGCACATTCAGGAAATCAGGTCCCTCAAAATTTCTAGCTCCCAACCCCATTGAGAGATT
TTGGGAGCTTTCCAATCTGCCACAAACTCCCTGCTACATATGTACTATATAGTTCAAATGTGTGATACAGAGCACCCTGAAAGGGAATAA
TTGAAACAAAGTTATAATCTTCTTAGTCTTATGCTAAATTTATTCCAGCCACCCTACTGAAGGGAGGAAGATCTGATCATTAGAATCCTT
TTCCTAGCCATGACACATTTACATACTTGTAAAATTTATTGTAGTAAGTCTAGCATTGCAACAGAATAGATCTTATAATGGCCAATCCTC
ACACTTTTGTATTAAGGATATTATGACAGACTAAGCATGGTAGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATC
AGCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGATAAAACACCATCTCTACTAAAAATACAAAAATTAGCTGGGCGCGGTGGTG
CATGCCTGTAATCCCAACTACTCGGGAGGCCGAGGCAGGAAAATTTATTGAACCTGGGAGGCAGAGGTTGTAGTGAGCCAAGGTCGCGCC
ACTGCGCTCCAGCCTGGACAACACAGTGAGACTCTGTCTCAAAAAAAAAAAAAAGACATTATGACAGATTTTATCTTTTAATAAAAATGT
ATTATATCCCTAAAGTTATATCTATATGTAATTGAGTCAGAAACCTAGGGGGATGTCGATTGAAGTCGACTGCTGGAAAAAAATAGCAGA
GCAACAAGATCCACACATTTAGAACCTCATAGAATTTGACACATTATTCATAATGGTGCAATTCTTTCTTTTTTATTCCAGTAAGCAAAT
TTACTAAATCACTAATTTGAAAAAAAAAATTTTTTTTTTGAGATGGAGTGTCACTCTGTTGCCGGGCTGGAGTGCAGTGGCACGATCTCT
GCTCACTGCAACCTCCGCCTCGCAGCTTCAAGTGATTGTCCTGCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCACACACCACCACGCC
CAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTGGCCAGAATGATGTCGATCTCCTGAACTCGTGATCCGCCCGCCTC
AGCCTCCCAAAGTAGCCTACATTGCCTCTACTTTGAAGGGACAAAGTTGTCCTGGTTTTTTTTTCCCTTTTATTATTTCATTATAACTAT
CCTAAAACTTACATACATTGCCTATGTTTGGCATTCCATAACATAATAATTATAATAATCCCCCAATGTCAGAAATGTATGTGTGAGTTC
CCATGTTTATTGGCAATTTATAAGCTTTTTAATATTGTACTATTTTAAACTAAAATGTAGAAAGAATATTATGTTTATATACAGTCAGAT
AAATTATTAACTGTTGTAATTTAAGCTGAAAATGAAACTATTTTAGTATCAGTATAGAAGAAAAGTATAGTTTCTAATCATCTATAATTT
TAAAATGCAAAGCCTATAAAACTTTCAAGATGTTTTGCCTGTTTGTTTTTAAGATTTATAATAATTTTCTATCTTTAGCAAGTAGCTATT
TTTAAGCCAGGTAACTTCTTTATTTGAACTGTATTATACTCTCAGACCCTCATCCTGCCTAGAAATGAATAAGTAATAAATAATTACTCT

>In-frame_ACER2_ENST00000340967_chr9_19435082_+_C8orf37_ENST00000286688_chr8_96276002_-_3696nt
AGCTGCTCCAATGCCCCGGAGTGGCCATGGGCGCCCCGCACTGGTGGGACCAGCTGCAGGCTGGTAGCTCGGAGGTGGACTGGTGCGAGG
ACAACTACACCATCGTGCCTGCTATCGCCGAGTTCTACAACACGATCAGCAATGTCTTATTTTTCATTTTACCGCCCATCTGCATGTGCT
TGTTTCGTCAGTATGCAACATGCTTCAACAGTGGCATCTACTTAATCTGGACTCTTTTGGTTGTAGTGGGAATTGGATCCGTCTACTTCC
ATGCAACCCTTAGTTTCTTGGGTCAGATGCTTGATGAACTTGCAGTCCTTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTCCCCAGAA
GGTATCTACCAAAGATCTTTCGGAATGACCGGGGTAGGTTCAAGGTGGTGGTCAGTGTCCTGTCTGCGGTTACGACGTGCCTGGCATTTG
TCAAGCCTGCCATCAACAACATCTCTCTGATGACCCTGGGAGTTCCTTGCACTGCACTGCTCATCGCAGAGCTAAAGAGATCAACAGAAA
CATTTAAAAAAGAAGATGATCTTGACAGTCTTATTAATGAAATACTTGAAGAGCCCAACTTGGACAAAAAACCCTCTAAATTAAAATCTA
AATCTTCAGGTAACACATCTGTCAGAGCTTCCATTGAAGGCCTTGGTAAAAGTTGCAGTCCGGTGTACCTTGGTGGAAGCTCTATTCCAT
GTGGGATTGGAACAAATATTTCATGGAGAGCATGTGACCATCTGCGTTGTATAGCCTGTGATTTCTTGGTAGTCAGCTATGATGACTATA
TGTGGGACAAATCGTGTGATTATCTGTTTTTCAGGAACAACATGCCAGAATTTCACAAATTAAAAGCAAAGTTGATAAAGAAGAAAGGAA
CACGGGCATATGCCTGCCAGTGTAGCTGGAGAACTATTGAAGAAGTGACTGACCTTCAGACAGATCATCAGCTTCGCTGGGTTTGTGGTA
AACATTAAGAATGCAGACTGCACATTCGGACAGATGCATCCATGAGAGTGGTCTCCATGAATCATCATCATGTTTAGACAATAGTCCCTA
GCAATACCATTCCCTGTGGGAAAAGGCAGTGAATTTTATTGATACAACTACATACATTTTTGAAGACCAAATGGACTAAGGAAGATCATG
TATTATAACACTTTGGAATTATTCCTGATACATGGATGTTTCACTTAGTAACAGGCATCTACATTCTTTACTAATCTGTCTTCTGTTTAA
TAGAGGTTTGATTATGGAGTTCCATACAAATATCTAGTTTTTCATTAGCAACTGCAATATTGATTGCTAATACGTTTAGCAAATCATTCC
CCAACTTGTAGCAGTTAAAGTGGATAAAGCCGGCCAGGGCAAAGAGATCATTTAGGGGTGTCTACAACACTTCTTCCAGTCAGATCTTTT
GTTGCCAAAGATCATAATTTGGACATGGCAGAAACCAGGTGATCAGTGGCTGACTGAAGGGTGTTCAGAAGTAGTTACAGGTATTTTGCA
AAAACACTGCCTCATAGCTGATCTTACCTCATCAACTCAAAGCAATGTTATGCACAATATTAAATACATGTTACCAGTTTTAGCTTATTT
TTCCCTCTTTTGTTCATTTAACTATCAAAAGTTATTTTCTATTTTGATTACCCAATAATATATAAAAAGAGTTTGATGCACCCAAAATCA
CAAAAATCCTAATACATACAGGTTATTGTTGGATTTTCCAAGTACTTTCTATCCTTTAATGCCTAAAACTCCATCAAGGGAAGTAAACAG
CAAGTAATATAATTTTTCAGGCAGCCTGTGGACTTCTCTGGTAGGATCAGGTTGACATATCGTTTATTAGGTGAGTAAGTGAAAAGACAA
GTAAAGCATAACTGAACCAACAGGTAACCTGTTGGGCTCCTTCCTGACATCACTGAGATCTGAGGAGCCCTACAATAGCAGCACATTCAG
GAAATCAGGTCCCTCAAAATTTCTAGCTCCCAACCCCATTGAGAGATTTTGGGAGCTTTCCAATCTGCCACAAACTCCCTGCTACATATG
TACTATATAGTTCAAATGTGTGATACAGAGCACCCTGAAAGGGAATAATTGAAACAAAGTTATAATCTTCTTAGTCTTATGCTAAATTTA
TTCCAGCCACCCTACTGAAGGGAGGAAGATCTGATCATTAGAATCCTTTTCCTAGCCATGACACATTTACATACTTGTAAAATTTATTGT
AGTAAGTCTAGCATTGCAACAGAATAGATCTTATAATGGCCAATCCTCACACTTTTGTATTAAGGATATTATGACAGACTAAGCATGGTA
GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCAGCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGATA
AAACACCATCTCTACTAAAAATACAAAAATTAGCTGGGCGCGGTGGTGCATGCCTGTAATCCCAACTACTCGGGAGGCCGAGGCAGGAAA
ATTTATTGAACCTGGGAGGCAGAGGTTGTAGTGAGCCAAGGTCGCGCCACTGCGCTCCAGCCTGGACAACACAGTGAGACTCTGTCTCAA
AAAAAAAAAAAAGACATTATGACAGATTTTATCTTTTAATAAAAATGTATTATATCCCTAAAGTTATATCTATATGTAATTGAGTCAGAA
ACCTAGGGGGATGTCGATTGAAGTCGACTGCTGGAAAAAAATAGCAGAGCAACAAGATCCACACATTTAGAACCTCATAGAATTTGACAC
ATTATTCATAATGGTGCAATTCTTTCTTTTTTATTCCAGTAAGCAAATTTACTAAATCACTAATTTGAAAAAAAAAATTTTTTTTTTGAG
ATGGAGTGTCACTCTGTTGCCGGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCGCCTCGCAGCTTCAAGTGATTGTCCT
GCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCACACACCACCACGCCCAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCAT
GTTGGCCAGAATGATGTCGATCTCCTGAACTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTAGCCTACATTGCCTCTACTTTGAAGGGAC
AAAGTTGTCCTGGTTTTTTTTTCCCTTTTATTATTTCATTATAACTATCCTAAAACTTACATACATTGCCTATGTTTGGCATTCCATAAC
ATAATAATTATAATAATCCCCCAATGTCAGAAATGTATGTGTGAGTTCCCATGTTTATTGGCAATTTATAAGCTTTTTAATATTGTACTA
TTTTAAACTAAAATGTAGAAAGAATATTATGTTTATATACAGTCAGATAAATTATTAACTGTTGTAATTTAAGCTGAAAATGAAACTATT
TTAGTATCAGTATAGAAGAAAAGTATAGTTTCTAATCATCTATAATTTTAAAATGCAAAGCCTATAAAACTTTCAAGATGTTTTGCCTGT
TTGTTTTTAAGATTTATAATAATTTTCTATCTTTAGCAAGTAGCTATTTTTAAGCCAGGTAACTTCTTTATTTGAACTGTATTATACTCT
CAGACCCTCATCCTGCCTAGAAATGAATAAGTAATAAATAATTACTCTGTATTATTTACTTCTTTTATTTTATAGTAAAATATTCATTTG


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FusionGenePPI for ACER2_C8orf37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACER2C8orf37MCM2, CAPNS1, CST6, XPNPEP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACER2_C8orf37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACER2_C8orf37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC8orf37C3281045CONE-ROD DYSTROPHY 162UNIPROT