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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37267

FusionGeneSummary for TARS_FGFR1OP

check button Fusion gene summary
Fusion gene informationFusion gene name: TARS_FGFR1OP
Fusion gene ID: 37267
HgeneTgene
Gene symbol

TARS

FGFR1OP

Gene ID

6897

11116

Gene namethreonyl-tRNA synthetaseFGFR1 oncogene partner
SynonymsThrRSFOP
Cytomap

5p13.3

6q27

Type of geneprotein-codingprotein-coding
Descriptionthreonine--tRNA ligase, cytoplasmicthreonine tRNA ligase 1, cytoplasmicthreonyl-tRNA synthetase, cytoplasmicFGFR1 oncogene partnerfibroblast growth factor receptor 1 oncogene partner
Modification date2018052320180519
UniProtAcc

P26639

O95684

Ensembl transtripts involved in fusion geneENST00000502553, ENST00000265112, 
ENST00000541634, ENST00000455217, 
ENST00000414361, ENST00000509410, 
ENST00000366847, ENST00000349556, 
ENST00000476078, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: TARS [Title/Abstract] AND FGFR1OP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR1OP

GO:0006469

negative regulation of protein kinase activity

17888034

TgeneFGFR1OP

GO:0008284

positive regulation of cell proliferation

17888034

TgeneFGFR1OP

GO:0030307

positive regulation of cell growth

17888034

TgeneFGFR1OP

GO:0030335

positive regulation of cell migration

17888034


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ312341TARSchr5

33461281

+FGFR1OPchr6

167446254

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000502553ENST00000366847TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000502553ENST00000349556TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000502553ENST00000476078TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000265112ENST00000366847TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000265112ENST00000349556TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000265112ENST00000476078TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000541634ENST00000366847TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000541634ENST00000349556TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000541634ENST00000476078TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000455217ENST00000366847TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000455217ENST00000349556TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000455217ENST00000476078TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000414361ENST00000366847TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000414361ENST00000349556TARSchr5

33461281

+FGFR1OPchr6

167446254

+
5CDS-intronENST00000414361ENST00000476078TARSchr5

33461281

+FGFR1OPchr6

167446254

+
3UTR-intronENST00000509410ENST00000366847TARSchr5

33461281

+FGFR1OPchr6

167446254

+
3UTR-intronENST00000509410ENST00000349556TARSchr5

33461281

+FGFR1OPchr6

167446254

+
3UTR-intronENST00000509410ENST00000476078TARSchr5

33461281

+FGFR1OPchr6

167446254

+

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FusionProtFeatures for TARS_FGFR1OP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TARS

P26639

FGFR1OP

O95684

Required for anchoring microtubules to the centrosomes(PubMed:16314388, PubMed:28659385). Required for ciliation(PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388,ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TARS_FGFR1OP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TARS_FGFR1OP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TARS_FGFR1OP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TARS_FGFR1OP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTARSC0027121Myositis1CTD_human