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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37264

FusionGeneSummary for TARS2_VPS45

check button Fusion gene summary
Fusion gene informationFusion gene name: TARS2_VPS45
Fusion gene ID: 37264
HgeneTgene
Gene symbol

TARS2

VPS45

Gene ID

80222

11311

Gene namethreonyl-tRNA synthetase 2, mitochondrialvacuolar protein sorting 45 homolog
SynonymsCOXPD21|TARSL1|thrRSH1|H1VPS45|SCN5|VPS45A|VPS45B|VPS54A|VSP45|VSP45A
Cytomap

1q21.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionthreonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1vacuolar protein sorting-associated protein 45leucocyte vacuolar protein sorting 45vacuolar protein sorting 45A
Modification date2018052320180519
UniProtAcc

Q9BW92

Q9NRW7

Ensembl transtripts involved in fusion geneENST00000438568, ENST00000369054, 
ENST00000369064, ENST00000606933, 
ENST00000463555, 
ENST00000369130, 
ENST00000369128, ENST00000535106, 
ENST00000484306, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 32
** MAII scorelog2(3/8*10)=1.90689059560852log2(2/8*10)=1.32192809488736
Context

PubMed: TARS2 [Title/Abstract] AND VPS45 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-6560-01ATARS2chr1

150464965

+VPS45chr1

150116887

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000438568ENST00000369130TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3CDSENST00000438568ENST00000369128TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3UTRENST00000438568ENST00000535106TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3UTRENST00000438568ENST00000484306TARS2chr1

150464965

+VPS45chr1

150116887

+
intron-3CDSENST00000369054ENST00000369130TARS2chr1

150464965

+VPS45chr1

150116887

+
intron-3CDSENST00000369054ENST00000369128TARS2chr1

150464965

+VPS45chr1

150116887

+
intron-3UTRENST00000369054ENST00000535106TARS2chr1

150464965

+VPS45chr1

150116887

+
intron-3UTRENST00000369054ENST00000484306TARS2chr1

150464965

+VPS45chr1

150116887

+
In-frameENST00000369064ENST00000369130TARS2chr1

150464965

+VPS45chr1

150116887

+
Frame-shiftENST00000369064ENST00000369128TARS2chr1

150464965

+VPS45chr1

150116887

+
5CDS-3UTRENST00000369064ENST00000535106TARS2chr1

150464965

+VPS45chr1

150116887

+
5CDS-3UTRENST00000369064ENST00000484306TARS2chr1

150464965

+VPS45chr1

150116887

+
In-frameENST00000606933ENST00000369130TARS2chr1

150464965

+VPS45chr1

150116887

+
Frame-shiftENST00000606933ENST00000369128TARS2chr1

150464965

+VPS45chr1

150116887

+
5CDS-3UTRENST00000606933ENST00000535106TARS2chr1

150464965

+VPS45chr1

150116887

+
5CDS-3UTRENST00000606933ENST00000484306TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3CDSENST00000463555ENST00000369130TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3CDSENST00000463555ENST00000369128TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3UTRENST00000463555ENST00000535106TARS2chr1

150464965

+VPS45chr1

150116887

+
3UTR-3UTRENST00000463555ENST00000484306TARS2chr1

150464965

+VPS45chr1

150116887

+

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FusionProtFeatures for TARS2_VPS45


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TARS2

Q9BW92

VPS45

Q9NRW7

Catalyzes the attachment of threonine to tRNA(Thr) in atwo-step reaction: threonine is first activated by ATP to formThr-AMP and then transferred to the acceptor end of tRNA(Thr).Also edits incorrectly charged tRNA(Thr) via its editing domain.{ECO:0000269|PubMed:26811336}. May play a role in vesicle-mediated protein traffickingfrom the Golgi stack through the trans-Golgi network.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TARS2_VPS45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TARS2_ENST00000369064_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_287aa
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

>In-frame_TARS2_ENST00000606933_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_287aa
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TARS2_ENST00000369064_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_862nt
ATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCTACACACGGCAGTTGTGTCGACCCCTCCACGC
TGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATTAGCAAGCATGGCACAGAAGGAACCCCGGACT
ATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCCCTACCAACTAGCCCGGCAGATCAGTTCAACA
CTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCCCTTGGAGACAGATTCTGACCTCAGATTTCTG
ACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTT
CTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTT
TTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAG
GATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGTATATGGGTGTGGCACATTGGTTGACCTTTGC
CAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAG

>In-frame_TARS2_ENST00000606933_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_862nt
ATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCTACACACGGCAGTTGTGTCGACCCCTCCACGC
TGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATTAGCAAGCATGGCACAGAAGGAACCCCGGACT
ATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCCCTACCAACTAGCCCGGCAGATCAGTTCAACA
CTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCCCTTGGAGACAGATTCTGACCTCAGATTTCTG
ACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTT
CTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTT
TTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAG
GATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGTATATGGGTGTGGCACATTGGTTGACCTTTGC
CAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TARS2_ENST00000369064_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_1427nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTT
TCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACG
GTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCT
GTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTC
TGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTG
ACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCC
TTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTT

>In-frame_TARS2_ENST00000606933_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_1424nt
TTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCT
ACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATT
AGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCC
CTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCC
CTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGG
GGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGA
GAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGC
TTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGT
ATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCC
TAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTG
GTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTG
CTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGA
GCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACT
TGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTA
ACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTT


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FusionGenePPI for TARS2_VPS45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TARS2ICT1, CUL3, AHSA1, CDC37, CHORDC1, FKBPL, EGFR, NTRK1, COQ9, CISD3, C2orf47, PTPN18VPS45RAB5A, SNTG1, RBSN, ZNF827, VTI1B, STX6, STX7, STX12, TMEM171, SLC39A4, GPRC5D, DAG1, SCFD1, VPS33A, VPS4B, NTRK1, BCAR3, CASP8, IGF1R, PAX2, PTPN1, RB1CC1, CEP152, CEP128, NINL, TMEM17, STX16, VAMP4, NIPAL3, LSR, RFX3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TARS2_VPS45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TARS2_VPS45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTARS2C4014668COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 211ORPHANET;UNIPROT
TgeneVPS45C1853118Severe congenital neutropenia1CTD_human
TgeneVPS45C2931351Familial myelofibrosis1CTD_human
TgeneVPS45C3809031NEUTROPENIA, SEVERE CONGENITAL, 5, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT