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Fusion gene ID: 37264 |
FusionGeneSummary for TARS2_VPS45 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TARS2_VPS45 | Fusion gene ID: 37264 | Hgene | Tgene | Gene symbol | TARS2 | VPS45 | Gene ID | 80222 | 11311 |
Gene name | threonyl-tRNA synthetase 2, mitochondrial | vacuolar protein sorting 45 homolog | |
Synonyms | COXPD21|TARSL1|thrRS | H1|H1VPS45|SCN5|VPS45A|VPS45B|VPS54A|VSP45|VSP45A | |
Cytomap | 1q21.2 | 1q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | threonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1 | vacuolar protein sorting-associated protein 45leucocyte vacuolar protein sorting 45vacuolar protein sorting 45A | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9BW92 | Q9NRW7 | |
Ensembl transtripts involved in fusion gene | ENST00000438568, ENST00000369054, ENST00000369064, ENST00000606933, ENST00000463555, | ENST00000369130, ENST00000369128, ENST00000535106, ENST00000484306, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/8*10)=1.90689059560852 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TARS2 [Title/Abstract] AND VPS45 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-85-6560-01A | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000438568 | ENST00000369130 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3CDS | ENST00000438568 | ENST00000369128 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3UTR | ENST00000438568 | ENST00000535106 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3UTR | ENST00000438568 | ENST00000484306 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
intron-3CDS | ENST00000369054 | ENST00000369130 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
intron-3CDS | ENST00000369054 | ENST00000369128 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
intron-3UTR | ENST00000369054 | ENST00000535106 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
intron-3UTR | ENST00000369054 | ENST00000484306 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
In-frame | ENST00000369064 | ENST00000369130 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
Frame-shift | ENST00000369064 | ENST00000369128 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
5CDS-3UTR | ENST00000369064 | ENST00000535106 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
5CDS-3UTR | ENST00000369064 | ENST00000484306 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
In-frame | ENST00000606933 | ENST00000369130 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
Frame-shift | ENST00000606933 | ENST00000369128 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
5CDS-3UTR | ENST00000606933 | ENST00000535106 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
5CDS-3UTR | ENST00000606933 | ENST00000484306 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3CDS | ENST00000463555 | ENST00000369130 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3CDS | ENST00000463555 | ENST00000369128 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3UTR | ENST00000463555 | ENST00000535106 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
3UTR-3UTR | ENST00000463555 | ENST00000484306 | TARS2 | chr1 | 150464965 | + | VPS45 | chr1 | 150116887 | + |
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FusionProtFeatures for TARS2_VPS45 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TARS2 | VPS45 |
Catalyzes the attachment of threonine to tRNA(Thr) in atwo-step reaction: threonine is first activated by ATP to formThr-AMP and then transferred to the acceptor end of tRNA(Thr).Also edits incorrectly charged tRNA(Thr) via its editing domain.{ECO:0000269|PubMed:26811336}. | May play a role in vesicle-mediated protein traffickingfrom the Golgi stack through the trans-Golgi network. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TARS2_VPS45 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TARS2_ENST00000369064_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_287aa MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ >In-frame_TARS2_ENST00000606933_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_287aa MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TARS2_ENST00000369064_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_862nt ATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCTACACACGGCAGTTGTGTCGACCCCTCCACGC TGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATTAGCAAGCATGGCACAGAAGGAACCCCGGACT ATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCCCTACCAACTAGCCCGGCAGATCAGTTCAACA CTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCCCTTGGAGACAGATTCTGACCTCAGATTTCTG ACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTT CTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTT TTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAG GATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGTATATGGGTGTGGCACATTGGTTGACCTTTGC CAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAG >In-frame_TARS2_ENST00000606933_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_862nt ATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCTACACACGGCAGTTGTGTCGACCCCTCCACGC TGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATTAGCAAGCATGGCACAGAAGGAACCCCGGACT ATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCCCTACCAACTAGCCCGGCAGATCAGTTCAACA CTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCCCTTGGAGACAGATTCTGACCTCAGATTTCTG ACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTT CTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTT TTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAG GATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGTATATGGGTGTGGCACATTGGTTGACCTTTGC CAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TARS2_ENST00000369064_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_1427nt CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTT TCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACG GTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCT GTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTC TGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTG ACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCC TTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTT >In-frame_TARS2_ENST00000606933_chr1_150464965_+_VPS45_ENST00000369130_chr1_150116887_+_1424nt TTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCT ACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATT AGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCC CTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCC CTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGG GGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGA GAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGC TTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGT ATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCC TAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTG GTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTG CTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGA GCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACT TGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTA ACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTT |
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FusionGenePPI for TARS2_VPS45 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TARS2 | ICT1, CUL3, AHSA1, CDC37, CHORDC1, FKBPL, EGFR, NTRK1, COQ9, CISD3, C2orf47, PTPN18 | VPS45 | RAB5A, SNTG1, RBSN, ZNF827, VTI1B, STX6, STX7, STX12, TMEM171, SLC39A4, GPRC5D, DAG1, SCFD1, VPS33A, VPS4B, NTRK1, BCAR3, CASP8, IGF1R, PAX2, PTPN1, RB1CC1, CEP152, CEP128, NINL, TMEM17, STX16, VAMP4, NIPAL3, LSR, RFX3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TARS2_VPS45 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TARS2_VPS45 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TARS2 | C4014668 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 21 | 1 | ORPHANET;UNIPROT |
Tgene | VPS45 | C1853118 | Severe congenital neutropenia | 1 | CTD_human |
Tgene | VPS45 | C2931351 | Familial myelofibrosis | 1 | CTD_human |
Tgene | VPS45 | C3809031 | NEUTROPENIA, SEVERE CONGENITAL, 5, AUTOSOMAL RECESSIVE | 1 | ORPHANET;UNIPROT |