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Fusion gene ID: 37252 |
FusionGeneSummary for TARBP1_ARID4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TARBP1_ARID4B | Fusion gene ID: 37252 | Hgene | Tgene | Gene symbol | TARBP1 | ARID4B | Gene ID | 6894 | 51742 |
| Gene name | TAR (HIV-1) RNA binding protein 1 | AT-rich interaction domain 4B | |
| Synonyms | TRM3|TRMT3|TRP-185|TRP185 | BCAA|BRCAA1|RBBP1L1|RBP1L1|SAP180 | |
| Cytomap | 1q42.2 | 1q42.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable methyltransferase TARBP1TAR (HIV) RNA-binding protein 1TAR RNA loop binding proteinTAR RNA-binding protein 1TAR RNA-binding protein of 185 kDatRNA methyltransferase 3 homolog | AT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1bre | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13395 | Q4LE39 | |
| Ensembl transtripts involved in fusion gene | ENST00000040877, ENST00000483404, | ENST00000366603, ENST00000264183, ENST00000349213, ENST00000494543, | |
| Fusion gene scores | * DoF score | 8 X 8 X 7=448 | 5 X 6 X 3=90 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TARBP1 [Title/Abstract] AND ARID4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-LB-A7SX-01A | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000040877 | ENST00000366603 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| Frame-shift | ENST00000040877 | ENST00000264183 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| Frame-shift | ENST00000040877 | ENST00000349213 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| 5CDS-5UTR | ENST00000040877 | ENST00000494543 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| intron-3CDS | ENST00000483404 | ENST00000366603 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| intron-3CDS | ENST00000483404 | ENST00000264183 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| intron-3CDS | ENST00000483404 | ENST00000349213 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
| intron-5UTR | ENST00000483404 | ENST00000494543 | TARBP1 | chr1 | 234553830 | - | ARID4B | chr1 | 235341228 | - |
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FusionProtFeatures for TARBP1_ARID4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TARBP1 | ARID4B |
| Probable S-adenosyl-L-methionine-dependentmethyltransferase which methylates RNA molecules such as tRNAs. Incase of infection by HIV-1, it binds to the loop region of TARRNA, a region also bound by RNA polymerase II. Binding of TARBP1and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive,suggesting that TARBP1 may function alone or in conjunction withHIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. Mayact by methylating HIV-1 TAR RNA. {ECO:0000269|PubMed:7638159,ECO:0000269|PubMed:8626763, ECO:0000269|PubMed:8846792}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TARBP1_ARID4B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TARBP1_ARID4B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TARBP1 | WDR48, SREK1, HSF4, BSG, LYPD3, RP2, SCN2B, FAF2, ASNA1, FASN, TARS, SASS6, HNRNPD, SYNCRIP, CHMP4B, BAG6, SCN3B, TNFRSF17, DLK2, RAB6B, SCGB2A2, NEFH, GMNN, RASL10B, C19orf45, PLA2G10, FAM19A3, VSIG1, SLC2A12, RGS20, CD79B | ARID4B | SIN3A, HDAC1, HDAC2, SUDS3, SAP130, ING2, RANBP2, ARID4A, SIRT1, ETS1, DDB1, CUL4B, MXD1, CASP1, CTSK, RBBP7, LACC1, LOC101929876, RPS26, SAP30, NTRK1, HIST1H2BG, KIF11, FOXK1, FOXK2, FBXW7, GATAD1, FAM60A, MXD3, ZNF704, PHF23, YAF2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TARBP1_ARID4B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TARBP1_ARID4B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ARID4B | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
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