|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37234 |
FusionGeneSummary for TAOK3_AGTPBP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAOK3_AGTPBP1 | Fusion gene ID: 37234 | Hgene | Tgene | Gene symbol | TAOK3 | AGTPBP1 | Gene ID | 51347 | 23287 |
| Gene name | TAO kinase 3 | ATP/GTP binding protein 1 | |
| Synonyms | DPK|JIK|MAP3K18|hKFC-A | CCP1|NNA1 | |
| Cytomap | 12q24.23 | 9q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase TAO3CTCL-associated antigen HD-CL-09JNK/SAPK-inhibitory kinaseSTE20-like kinasecutaneous T-cell lymphoma-associated antigen HD-CL-09dendritic cell-derived protein kinasejun kinase-inhibitory kinasekinase from chicken | cytosolic carboxypeptidase 1carboxypeptidase-tubulinnervous system nuclear protein induced by axotomy protein 1 homologsoluble carboxypeptidasetubulinyl-Tyr carboxypeptidasetyrosine carboxypeptidase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H2K8 | Q9UPW5 | |
| Ensembl transtripts involved in fusion gene | ENST00000419821, ENST00000392533, ENST00000537952, ENST00000543709, ENST00000536979, | ENST00000337006, ENST00000376083, ENST00000357081, ENST00000376109, ENST00000432218, ENST00000376081, ENST00000491784, ENST00000376080, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 4 X 3 X 4=48 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAOK3 [Title/Abstract] AND AGTPBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK3 | GO:0006468 | protein phosphorylation | 10559204 |
| Hgene | TAOK3 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Hgene | TAOK3 | GO:0046329 | negative regulation of JNK cascade | 10559204 |
| Hgene | TAOK3 | GO:0046777 | protein autophosphorylation | 10559204 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-CH-5794-01A | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000419821 | ENST00000337006 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000419821 | ENST00000376083 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000419821 | ENST00000357081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000419821 | ENST00000376109 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000419821 | ENST00000432218 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000419821 | ENST00000376081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000419821 | ENST00000491784 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000419821 | ENST00000376080 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-5UTR | ENST00000392533 | ENST00000337006 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-5UTR | ENST00000392533 | ENST00000376083 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-5UTR | ENST00000392533 | ENST00000357081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-intron | ENST00000392533 | ENST00000376109 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-intron | ENST00000392533 | ENST00000432218 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-5UTR | ENST00000392533 | ENST00000376081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-intron | ENST00000392533 | ENST00000491784 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| 5UTR-intron | ENST00000392533 | ENST00000376080 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000537952 | ENST00000337006 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000537952 | ENST00000376083 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000537952 | ENST00000357081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000537952 | ENST00000376109 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000537952 | ENST00000432218 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000537952 | ENST00000376081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000537952 | ENST00000491784 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000537952 | ENST00000376080 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000543709 | ENST00000337006 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000543709 | ENST00000376083 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000543709 | ENST00000357081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000543709 | ENST00000376109 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000543709 | ENST00000432218 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000543709 | ENST00000376081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000543709 | ENST00000491784 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000543709 | ENST00000376080 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000536979 | ENST00000337006 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000536979 | ENST00000376083 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000536979 | ENST00000357081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000536979 | ENST00000376109 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000536979 | ENST00000432218 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-5UTR | ENST00000536979 | ENST00000376081 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000536979 | ENST00000491784 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
| intron-intron | ENST00000536979 | ENST00000376080 | TAOK3 | chr12 | 118810453 | - | AGTPBP1 | chr9 | 88327481 | - |
Top |
FusionProtFeatures for TAOK3_AGTPBP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK3 | AGTPBP1 |
| Serine/threonine-protein kinase that acts as a regulatorof the p38/MAPK14 stress-activated MAPK cascade and of theMAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in theG2/M transition DNA damage checkpoint by activating the p38/MAPK14stress-activated MAPK cascade, probably by mediatingphosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibitsbasal activity of MAPK8/JNK cascade and diminishes its activationin response epidermal growth factor (EGF).{ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369,ECO:0000269|PubMed:17396146}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TAOK3_AGTPBP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TAOK3_AGTPBP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAOK3 | TRAF2, ERN1, ATM, LRRK2, HSP90AA1, ATF7, CTR9, SMURF1, TRIM25 | AGTPBP1 | DISC1, TNIK, CYCS, NYNRIN, CBY1, PPFIA1, PPFIA4, ENO1, PNKP, TMOD1, CEP128, XPO1, FOXK1, EGFR, PHLPP1, TTLL4, UBC, FBXL13 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TAOK3_AGTPBP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TAOK3_AGTPBP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | AGTPBP1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|