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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3722

FusionGeneSummary for B4GALNT3_CCDC77

check button Fusion gene summary
Fusion gene informationFusion gene name: B4GALNT3_CCDC77
Fusion gene ID: 3722
HgeneTgene
Gene symbol

B4GALNT3

CCDC77

Gene ID

283358

84318

Gene namebeta-1,4-N-acetyl-galactosaminyltransferase 3coiled-coil domain containing 77
Synonyms--
Cytomap

12p13.33

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-N-acetylgalactosaminyltransferase 3B4GalNAcT3Beta4GalNAc-T3N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferaseN-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2NGalNAc-T2beta-1,4coiled-coil domain-containing protein 77
Modification date2018051920180523
UniProtAcc

Q6L9W6

Q9BR77

Ensembl transtripts involved in fusion geneENST00000266383, ENST00000544638, 
ENST00000540180, ENST00000422000, 
ENST00000540344, ENST00000239830, 
ENST00000412006, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 5 X 3=45
# samples 74
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B4GALNT3 [Title/Abstract] AND CCDC77 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A0J2-01AB4GALNT3chr12

569711

+CCDC77chr12

520913

+
TCGALDBRCATCGA-AO-A0J2-01AB4GALNT3chr12

569711

+CCDC77chr12

527660

+
TCGALDPRADTCGA-FC-A66V-01AB4GALNT3chr12

569711

+CCDC77chr12

547501

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000266383ENST00000540180B4GALNT3chr12

569711

+CCDC77chr12

520913

+
5CDS-5UTRENST00000266383ENST00000422000B4GALNT3chr12

569711

+CCDC77chr12

520913

+
5CDS-3UTRENST00000266383ENST00000540344B4GALNT3chr12

569711

+CCDC77chr12

520913

+
5CDS-3UTRENST00000266383ENST00000239830B4GALNT3chr12

569711

+CCDC77chr12

520913

+
5CDS-5UTRENST00000266383ENST00000412006B4GALNT3chr12

569711

+CCDC77chr12

520913

+
intron-5UTRENST00000544638ENST00000540180B4GALNT3chr12

569711

+CCDC77chr12

520913

+
intron-5UTRENST00000544638ENST00000422000B4GALNT3chr12

569711

+CCDC77chr12

520913

+
intron-3UTRENST00000544638ENST00000540344B4GALNT3chr12

569711

+CCDC77chr12

520913

+
intron-3UTRENST00000544638ENST00000239830B4GALNT3chr12

569711

+CCDC77chr12

520913

+
intron-5UTRENST00000544638ENST00000412006B4GALNT3chr12

569711

+CCDC77chr12

520913

+
Frame-shiftENST00000266383ENST00000540180B4GALNT3chr12

569711

+CCDC77chr12

527660

+
Frame-shiftENST00000266383ENST00000422000B4GALNT3chr12

569711

+CCDC77chr12

527660

+
5CDS-3UTRENST00000266383ENST00000540344B4GALNT3chr12

569711

+CCDC77chr12

527660

+
5CDS-3UTRENST00000266383ENST00000239830B4GALNT3chr12

569711

+CCDC77chr12

527660

+
5CDS-3UTRENST00000266383ENST00000412006B4GALNT3chr12

569711

+CCDC77chr12

527660

+
intron-3CDSENST00000544638ENST00000540180B4GALNT3chr12

569711

+CCDC77chr12

527660

+
intron-3CDSENST00000544638ENST00000422000B4GALNT3chr12

569711

+CCDC77chr12

527660

+
intron-3UTRENST00000544638ENST00000540344B4GALNT3chr12

569711

+CCDC77chr12

527660

+
intron-3UTRENST00000544638ENST00000239830B4GALNT3chr12

569711

+CCDC77chr12

527660

+
intron-3UTRENST00000544638ENST00000412006B4GALNT3chr12

569711

+CCDC77chr12

527660

+
Frame-shiftENST00000266383ENST00000540180B4GALNT3chr12

569711

+CCDC77chr12

547501

+
Frame-shiftENST00000266383ENST00000422000B4GALNT3chr12

569711

+CCDC77chr12

547501

+
5CDS-intronENST00000266383ENST00000540344B4GALNT3chr12

569711

+CCDC77chr12

547501

+
5CDS-intronENST00000266383ENST00000239830B4GALNT3chr12

569711

+CCDC77chr12

547501

+
5CDS-intronENST00000266383ENST00000412006B4GALNT3chr12

569711

+CCDC77chr12

547501

+
intron-3CDSENST00000544638ENST00000540180B4GALNT3chr12

569711

+CCDC77chr12

547501

+
intron-3CDSENST00000544638ENST00000422000B4GALNT3chr12

569711

+CCDC77chr12

547501

+
intron-intronENST00000544638ENST00000540344B4GALNT3chr12

569711

+CCDC77chr12

547501

+
intron-intronENST00000544638ENST00000239830B4GALNT3chr12

569711

+CCDC77chr12

547501

+
intron-intronENST00000544638ENST00000412006B4GALNT3chr12

569711

+CCDC77chr12

547501

+

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FusionProtFeatures for B4GALNT3_CCDC77


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B4GALNT3

Q6L9W6

CCDC77

Q9BR77

Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNActo N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to formN,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures inN-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa.{ECO:0000269|PubMed:16728562}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for B4GALNT3_CCDC77


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for B4GALNT3_CCDC77


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B4GALNT3PILRA, SCGB2A2, GAACCDC77LATS2, LTBR, MED4, CEP290, PCM1, CEP170, KIAA0753, CEP120, SPICE1, CEP128, CEP135, CEP63, CEP89, NINL, ODF2, PRKAR2B, OFD1, DYNLL1, FGFR1OP, MAPRE1, CCDC14, NEDD1, KIF7, PPP2R3C, CDC14A, TPTE2, IKZF5, PRDM5, CCDC136, SYT12, MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B4GALNT3_CCDC77


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for B4GALNT3_CCDC77


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource