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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37210

FusionGeneSummary for TAOK1_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: TAOK1_BCAS3
Fusion gene ID: 37210
HgeneTgene
Gene symbol

TAOK1

BCAS3

Gene ID

57551

54828

Gene nameTAO kinase 1BCAS3, microtubule associated cell migration factor
SynonymsKFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1GAOB1|MAAB
Cytomap

17q11.2

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kinbreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

Q7L7X3

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000261716, ENST00000536202, 
ENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
Fusion gene scores* DoF score27 X 13 X 16=561626 X 15 X 15=5850
# samples 2841
** MAII scorelog2(28/5616*10)=-4.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAOK1 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAOK1

GO:0006974

cellular response to DNA damage stimulus

17396146

HgeneTAOK1

GO:0046330

positive regulation of JNK cascade

16407310

HgeneTAOK1

GO:0097194

execution phase of apoptosis

16407310

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-91-6847-01ATAOK1chr17

27838010

+BCAS3chr17

58885365

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000261716ENST00000589222TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000261716ENST00000407086TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000261716ENST00000390652TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000261716ENST00000408905TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000261716ENST00000588462TAOK1chr17

27838010

+BCAS3chr17

58885365

+
5CDS-intronENST00000261716ENST00000585744TAOK1chr17

27838010

+BCAS3chr17

58885365

+
5CDS-intronENST00000261716ENST00000588874TAOK1chr17

27838010

+BCAS3chr17

58885365

+
5CDS-intronENST00000261716ENST00000585812TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000536202ENST00000589222TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000536202ENST00000407086TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000536202ENST00000390652TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000536202ENST00000408905TAOK1chr17

27838010

+BCAS3chr17

58885365

+
Frame-shitENST00000536202ENST00000588462TAOK1chr17

27838010

+BCAS3chr17

58885365

+
5CDS-intronENST00000536202ENST00000585744TAOK1chr17

27838010

+BCAS3chr17

58885365

+
5CDS-intronENST00000536202ENST00000588874TAOK1chr17

27838010

+BCAS3chr17

58885365

+
5CDS-intronENST00000536202ENST00000585812TAOK1chr17

27838010

+BCAS3chr17

58885365

+

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FusionProtFeatures for TAOK1_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAOK1

Q7L7X3

BCAS3

Q9H6U6

Serine/threonine-protein kinase involved in variousprocesses such as p38/MAPK14 stress-activated MAPK cascade, DNAdamage response and regulation of cytoskeleton stability.Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator ofthe p38/MAPK14 stress-activated MAPK cascade by mediatingphosphorylation and subsequent activation of the upstream MAP2K3and MAP2K6 kinases. Involved in G-protein coupled receptorsignaling to p38/MAPK14. In response to DNA damage, involved inthe G2/M transition DNA damage checkpoint by activating thep38/MAPK14 stress-activated MAPK cascade, probably by mediatingphosphorylation of MAP2K3 and MAP2K6. Acts as a regulator ofcytoskeleton stability by phosphorylating 'Thr-208' of MARK2,leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Alsoacts as a regulator of apoptosis: regulates apoptoticmorphological changes, including cell contraction, membraneblebbing and apoptotic bodies formation via activation of theMAPK8/JNK cascade. {ECO:0000269|PubMed:12665513,ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310,ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAOK1_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAOK1_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAOK1STK4, CSNK1E, DYNC1I1, GEMIN7, WT1, C8orf33, SRBD1, MAP3K7, STK25, STK26, NTRK1, SNW1, FAM206ABCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAOK1_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAOK1_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAOK1C0018781Noise-induced hearing loss1CTD_human