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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37203

FusionGeneSummary for TANK_CACNB4

check button Fusion gene summary
Fusion gene informationFusion gene name: TANK_CACNB4
Fusion gene ID: 37203
HgeneTgene
Gene symbol

TANK

CACNB4

Gene ID

10010

785

Gene nameTRAF family member associated NFKB activatorcalcium voltage-gated channel auxiliary subunit beta 4
SynonymsI-TRAF|ITRAF|TRAF2CAB4|CACNLB4|EA5|EIG9|EJM|EJM4|EJM6
Cytomap

2q24.2

2q23.3

Type of geneprotein-codingprotein-coding
DescriptionTRAF family member-associated NF-kappa-B activatorTRAF-interacting proteinvoltage-dependent L-type calcium channel subunit beta-4calcium channel voltage-dependent subunit beta 4dihydropyridine-sensitive L-type, calcium channel beta-4 subunit
Modification date2018052320180523
UniProtAcc

Q92844

O00305

Ensembl transtripts involved in fusion geneENST00000259075, ENST00000457476, 
ENST00000392749, ENST00000461338, 
ENST00000402568, ENST00000406287, 
ENST00000405852, ENST00000403609, 
ENST00000539935, ENST00000360283, 
ENST00000534999, ENST00000397327, 
ENST00000427385, ENST00000201943, 
ENST00000475848, 
Fusion gene scores* DoF score3 X 2 X 2=122 X 2 X 2=8
# samples 22
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: TANK [Title/Abstract] AND CACNB4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A8C2-01ATANKchr2

162016997

+CACNB4chr2

152739884

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000259075ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000259075ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000259075ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000259075ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000259075ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000259075ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-5UTRENST00000259075ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000457476ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000457476ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000457476ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000457476ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000457476ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000457476ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-5UTRENST00000457476ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000392749ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000392749ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000392749ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000392749ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000392749ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000392749ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-5UTRENST00000392749ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-3CDSENST00000461338ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-3CDSENST00000461338ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-3CDSENST00000461338ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-3CDSENST00000461338ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-3CDSENST00000461338ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-3CDSENST00000461338ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
3UTR-5UTRENST00000461338ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000402568ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000402568ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000402568ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000402568ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000402568ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000402568ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-5UTRENST00000402568ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000406287ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000406287ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000406287ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000406287ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000406287ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000406287ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-5UTRENST00000406287ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000405852ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000405852ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000405852ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000405852ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000405852ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-3CDSENST00000405852ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
5UTR-5UTRENST00000405852ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000403609ENST00000539935TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000403609ENST00000360283TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000403609ENST00000534999TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000403609ENST00000397327TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000403609ENST00000427385TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-3CDSENST00000403609ENST00000201943TANKchr2

162016997

+CACNB4chr2

152739884

-
intron-5UTRENST00000403609ENST00000475848TANKchr2

162016997

+CACNB4chr2

152739884

-

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FusionProtFeatures for TANK_CACNB4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANK

Q92844

CACNB4

O00305

Adapter protein involved in I-kappa-B-kinase (IKK)regulation which constitutively binds TBK1 and IKBKE playing arole in antiviral innate immunity. Acts as a regulator of TRAFfunction by maintaining them in a latent state. Blocks TRAF2binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation.Negatively regulates NF-kappaB signaling and cell survival uponDNA damage (PubMed:25861989). Plays a role as an adapter toassemble ZC3H12A, USP10 in a deubiquitination complex which playsa negative feedback response to attenuate NF-kappaB activationthrough the deubiquitination of IKBKG or TRAF6 in response tointerleukin-1-beta (IL1B) stimulation or upon DNA damage(PubMed:25861989). Promotes UBP10-induced deubiquitination ofTRAF6 in response to DNA damage (PubMed:25861989). May controlnegatively TRAF2-mediated NF-kappa-B activation signaled by CD40,TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833,ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. The beta subunit of voltage-dependent calcium channelscontributes to the function of the calcium channel by increasingpeak calcium current, shifting the voltage dependencies ofactivation and inactivation, modulating G protein inhibition andcontrolling the alpha-1 subunit membrane targeting.{ECO:0000269|PubMed:11880487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TANK_CACNB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TANK_CACNB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TANKZC3H12A, TRAF3, TBK1, TRAF2, TRAF1, ITGB1BP1, IKBKG, CHUK, IKBKE, IRF7, IRF3, PLK1, MARCH5, APBA3, BIRC2, TICAM1, HERC2, TAB2, CBLB, CD40, MAP3K14, TANK, APP, BIRC3, HLA-C, LAMC1, AIMP2, COPB1, FBLN1, ATP6V1H, BIK, KPNA2, SMAD3, SDC4, RACGAP1, INPP5K, TP53BP2, SRSF11, CEP63, ZFP36, SUMO2, BBOX1, CEP128, USP10, TRAF6, PBXIP1CACNB4TBL3, MED31, PTN, CACNA1A, CBX3, FASLG, CACNB3, COLGALT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TANK_CACNB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCACNB4O00305DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-4 {ECO:0000305}small moleculeapproved
TgeneCACNB4O00305DB04855DronedaroneVoltage-dependent L-type calcium channel subunit beta-4 {ECO:0000305}small moleculeapproved
TgeneCACNB4O00305DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-4 {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for TANK_CACNB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTANKC1458155Mammary Neoplasms1CTD_human
TgeneCACNB4C0004134Ataxia1CTD_human
TgeneCACNB4C0014548Epilepsy, Generalized1CTD_human
TgeneCACNB4C0270853Myoclonic Epilepsy, Juvenile1CTD_human;ORPHANET
TgeneCACNB4C1866039EPISODIC ATAXIA, TYPE 51CTD_human;ORPHANET;UNIPROT