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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37195

FusionGeneSummary for TANGO6_CFDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TANGO6_CFDP1
Fusion gene ID: 37195
HgeneTgene
Gene symbol

TANGO6

CFDP1

Gene ID

79613

10428

Gene nametransport and golgi organization 6 homologcraniofacial development protein 1
SynonymsTMCO7BCNT|BUCENTAUR|CENP-29|CP27|SWC5|Yeti|p97
Cytomap

16q22.1

16q23.1

Type of geneprotein-codingprotein-coding
Descriptiontransport and Golgi organization protein 6 homologtransmembrane and coiled-coil domain-containing protein 7transmembrane and coiled-coil domains 7craniofacial development protein 1centromere protein 29phosphoprotein (Bucentaur)
Modification date2018051920180519
UniProtAcc

Q9C0B7

Q9UEE9

Ensembl transtripts involved in fusion geneENST00000261778, ENST00000561931, 
ENST00000283882, ENST00000564286, 
Fusion gene scores* DoF score9 X 8 X 7=50411 X 7 X 11=847
# samples 918
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/847*10)=-2.23436506300252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TANGO6 [Title/Abstract] AND CFDP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-GF-A6C8-06ATANGO6chr16

68877614

+CFDP1chr16

75339080

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261778ENST00000283882TANGO6chr16

68877614

+CFDP1chr16

75339080

-
5CDS-intronENST00000261778ENST00000564286TANGO6chr16

68877614

+CFDP1chr16

75339080

-
intron-3CDSENST00000561931ENST00000283882TANGO6chr16

68877614

+CFDP1chr16

75339080

-
intron-intronENST00000561931ENST00000564286TANGO6chr16

68877614

+CFDP1chr16

75339080

-

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FusionProtFeatures for TANGO6_CFDP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANGO6

Q9C0B7

CFDP1

Q9UEE9

May play a role during embryogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TANGO6_CFDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TANGO6_CFDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TANGO6MACF1, UBE2S, CAPZA2, P4HA2, MTNR1B, ZNHIT2, RPAP3, RUVBL1, RUVBL2, URI1, WDR92CFDP1EWSR1, APP, DMAP1, SRCAP, SMAD3, TALDO1, HIST1H2BA, RUVBL1, RUVBL2, RBPJ, ID2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TANGO6_CFDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TANGO6_CFDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource