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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37194

FusionGeneSummary for TANGO6_ARHGAP26

check button Fusion gene summary
Fusion gene informationFusion gene name: TANGO6_ARHGAP26
Fusion gene ID: 37194
HgeneTgene
Gene symbol

TANGO6

ARHGAP26

Gene ID

79613

23092

Gene nametransport and golgi organization 6 homologRho GTPase activating protein 26
SynonymsTMCO7GRAF|GRAF1|OPHN1L|OPHN1L1
Cytomap

16q22.1

5q31.3

Type of geneprotein-codingprotein-coding
Descriptiontransport and Golgi organization protein 6 homologtransmembrane and coiled-coil domain-containing protein 7transmembrane and coiled-coil domains 7rho GTPase-activating protein 26GTPase regulator associated with focal adhesion kinase pp125(FAK)oligophrenin-1-like protein
Modification date2018051920180523
UniProtAcc

Q9C0B7

Q9UNA1

Ensembl transtripts involved in fusion geneENST00000261778, ENST00000561931, 
ENST00000378004, ENST00000274498, 
ENST00000486650, 
Fusion gene scores* DoF score9 X 8 X 7=50416 X 20 X 7=2240
# samples 927
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/2240*10)=-3.05246741989414
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TANGO6 [Title/Abstract] AND ARHGAP26 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW862884TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261778ENST00000378004TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-
5CDS-intronENST00000261778ENST00000274498TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-
5CDS-intronENST00000261778ENST00000486650TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-
intron-intronENST00000561931ENST00000378004TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-
intron-intronENST00000561931ENST00000274498TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-
intron-intronENST00000561931ENST00000486650TANGO6chr16

69008008

+ARHGAP26chr5

142562548

-

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FusionProtFeatures for TANGO6_ARHGAP26


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANGO6

Q9C0B7

ARHGAP26

Q9UNA1

GTPase-activating protein for RHOA and CDC42.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TANGO6_ARHGAP26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TANGO6_ARHGAP26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TANGO6_ARHGAP26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TANGO6_ARHGAP26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARHGAP26C0033975Psychotic Disorders1PSYGENET
TgeneARHGAP26C0349639Juvenile Myelomonocytic Leukemia1CTD_human;HPO;UNIPROT