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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37154

FusionGeneSummary for TALDO1_TALDO1

check button Fusion gene summary
Fusion gene informationFusion gene name: TALDO1_TALDO1
Fusion gene ID: 37154
HgeneTgene
Gene symbol

TALDO1

TALDO1

Gene ID

6888

6888

Gene nametransaldolase 1transaldolase 1
SynonymsTAL|TAL-H|TALDOR|TALHTAL|TAL-H|TALDOR|TALH
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
Descriptiontransaldolasedihydroxyacetone transferaseglycerone transferasetesticular secretory protein Li 56transaldolasedihydroxyacetone transferaseglycerone transferasetesticular secretory protein Li 56
Modification date2018052320180523
UniProtAcc

P37837

P37837

Ensembl transtripts involved in fusion geneENST00000319006, ENST00000528097, 
ENST00000532202, 
ENST00000319006, 
ENST00000528097, ENST00000532202, 
Fusion gene scores* DoF score4 X 4 X 5=806 X 4 X 4=96
# samples 68
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TALDO1 [Title/Abstract] AND TALDO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV375270TALDO1chr11

755897

-TALDO1chr11

763885

+
ChiTaRS3.1BQ334187TALDO1chr11

755897

-TALDO1chr11

763885

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000319006ENST00000319006TALDO1chr11

755897

-TALDO1chr11

763885

+
Frame-shiftENST00000319006ENST00000528097TALDO1chr11

755897

-TALDO1chr11

763885

+
5CDS-intronENST00000319006ENST00000532202TALDO1chr11

755897

-TALDO1chr11

763885

+
Frame-shiftENST00000528097ENST00000319006TALDO1chr11

755897

-TALDO1chr11

763885

+
Frame-shiftENST00000528097ENST00000528097TALDO1chr11

755897

-TALDO1chr11

763885

+
5CDS-intronENST00000528097ENST00000532202TALDO1chr11

755897

-TALDO1chr11

763885

+
intron-3CDSENST00000532202ENST00000319006TALDO1chr11

755897

-TALDO1chr11

763885

+
intron-3CDSENST00000532202ENST00000528097TALDO1chr11

755897

-TALDO1chr11

763885

+
intron-intronENST00000532202ENST00000532202TALDO1chr11

755897

-TALDO1chr11

763885

+

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FusionProtFeatures for TALDO1_TALDO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TALDO1

P37837

TALDO1

P37837

Transaldolase is important for the balance ofmetabolites in the pentose-phosphate pathway. Transaldolase is important for the balance ofmetabolites in the pentose-phosphate pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TALDO1_TALDO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TALDO1_TALDO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TALDO1_TALDO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TALDO1_TALDO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTALDO1C0030567Parkinson Disease1CTD_human
HgeneTALDO1C2239176Liver carcinoma1CTD_human
HgeneTALDO1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneTALDO1C0030567Parkinson Disease1CTD_human
TgeneTALDO1C2239176Liver carcinoma1CTD_human
TgeneTALDO1C4277682Chemical and Drug Induced Liver Injury1CTD_human