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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37147

FusionGeneSummary for TAGLN_LRRC61

check button Fusion gene summary
Fusion gene informationFusion gene name: TAGLN_LRRC61
Fusion gene ID: 37147
HgeneTgene
Gene symbol

TAGLN

LRRC61

Gene ID

6876

65999

Gene nametransgelinleucine rich repeat containing 61
SynonymsSM22|SM22-alpha|SMCC|TAGLN1|WS3-10HSPC295
Cytomap

11q23.3

7q36.1

Type of geneprotein-codingprotein-coding
Descriptiontransgelin22 kDa actin-binding proteinsmooth muscle protein 22-alphatransgelin variant 2leucine-rich repeat-containing protein 61
Modification date2018051920180523
UniProtAcc

Q01995

Q9BV99

Ensembl transtripts involved in fusion geneENST00000392951, ENST00000530649, 
ENST00000532870, 
ENST00000463441, 
ENST00000323078, ENST00000359623, 
ENST00000493307, 
Fusion gene scores* DoF score7 X 13 X 2=1822 X 1 X 1=2
# samples 173
** MAII scorelog2(17/182*10)=-0.0984037040609945
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/2*10)=3.90689059560852
Context

PubMed: TAGLN [Title/Abstract] AND LRRC61 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAGLN

GO:0030855

epithelial cell differentiation

21492153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA468776TAGLNchr11

117075434

-LRRC61chr7

150034797

-
ChiTaRS3.1AA468630TAGLNchr11

117075434

-LRRC61chr7

150034797

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000392951ENST00000463441TAGLNchr11

117075434

-LRRC61chr7

150034797

-
intron-3UTRENST00000392951ENST00000323078TAGLNchr11

117075434

-LRRC61chr7

150034797

-
intron-3UTRENST00000392951ENST00000359623TAGLNchr11

117075434

-LRRC61chr7

150034797

-
intron-intronENST00000392951ENST00000493307TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-intronENST00000530649ENST00000463441TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-3UTRENST00000530649ENST00000323078TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-3UTRENST00000530649ENST00000359623TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-intronENST00000530649ENST00000493307TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-intronENST00000532870ENST00000463441TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-3UTRENST00000532870ENST00000323078TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-3UTRENST00000532870ENST00000359623TAGLNchr11

117075434

-LRRC61chr7

150034797

-
3UTR-intronENST00000532870ENST00000493307TAGLNchr11

117075434

-LRRC61chr7

150034797

-

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FusionProtFeatures for TAGLN_LRRC61


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAGLN

Q01995

LRRC61

Q9BV99

Actin cross-linking/gelling protein (By similarity).Involved in calcium interactions and contractile properties of thecell that may contribute to replicative senescence. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAGLN_LRRC61


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAGLN_LRRC61


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAGLN_LRRC61


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAGLN_LRRC61


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAGLNC0023794Lipoidosis3CTD_human
HgeneTAGLNC0009375Colonic Neoplasms1CTD_human
HgeneTAGLNC0014175Endometriosis1CTD_human
HgeneTAGLNC0022548Keloid1CTD_human
HgeneTAGLNC0279626Squamous cell carcinoma of esophagus1CTD_human