FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3714

FusionGeneSummary for B3GNT4_TSPAN31

check button Fusion gene summary
Fusion gene informationFusion gene name: B3GNT4_TSPAN31
Fusion gene ID: 3714
HgeneTgene
Gene symbol

B3GNT4

TSPAN31

Gene ID

79369

6302

Gene nameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4tetraspanin 31
SynonymsB3GN-T4|beta3Gn-T4SAS
Cytomap

12q24.31

12q14.1

Type of geneprotein-codingprotein-coding
DescriptionN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4BGnT-4beta-1,3-Gn-T4beta-1,3-N-acetylglucosaminyltransferase 4beta-1,3-N-acetylglucosaminyltransferase bGn-T4tetraspanin-31sarcoma-amplified sequencetransmembrane 4 proteintspan-31
Modification date2018052320180523
UniProtAcc

Q9C0J1

Q12999

Ensembl transtripts involved in fusion geneENST00000324189, ENST00000546192, 
ENST00000545141, ENST00000535274, 
ENST00000553221, ENST00000257910, 
ENST00000547992, ENST00000547472, 
Fusion gene scores* DoF score2 X 2 X 3=1211 X 4 X 4=176
# samples 310
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/176*10)=-0.815575428862573
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B3GNT4 [Title/Abstract] AND TSPAN31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneB3GNT4

GO:0030311

poly-N-acetyllactosamine biosynthetic process

11042166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3LS-01AB3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000324189ENST00000553221B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-3UTRENST00000324189ENST00000257910B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-3UTRENST00000324189ENST00000547992B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-intronENST00000324189ENST00000547472B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-3UTRENST00000546192ENST00000553221B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-3UTRENST00000546192ENST00000257910B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-3UTRENST00000546192ENST00000547992B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-intronENST00000546192ENST00000547472B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-3UTRENST00000545141ENST00000553221B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-3UTRENST00000545141ENST00000257910B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-3UTRENST00000545141ENST00000547992B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
3UTR-intronENST00000545141ENST00000547472B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-3UTRENST00000535274ENST00000553221B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-3UTRENST00000535274ENST00000257910B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-3UTRENST00000535274ENST00000547992B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+
intron-intronENST00000535274ENST00000547472B3GNT4chr12

122692359

+TSPAN31chr12

58139528

+

Top

FusionProtFeatures for B3GNT4_TSPAN31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B3GNT4

Q9C0J1

TSPAN31

Q12999

Beta-1,3-N-acetylglucosaminyltransferase involved in thesynthesis of poly-N-acetyllactosamine. Has activity for type 2oligosaccharides. {ECO:0000269|PubMed:11042166}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for B3GNT4_TSPAN31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for B3GNT4_TSPAN31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B3GNT4CUL4BTSPAN31ELAVL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for B3GNT4_TSPAN31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for B3GNT4_TSPAN31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource