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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37139

FusionGeneSummary for TAGLN2_PBX1

check button Fusion gene summary
Fusion gene informationFusion gene name: TAGLN2_PBX1
Fusion gene ID: 37139
HgeneTgene
Gene symbol

TAGLN2

PBX1

Gene ID

8407

5087

Gene nametransgelin 2PBX homeobox 1
SynonymsHA1756CAKUHED
Cytomap

1q23.2

1q23.3

Type of geneprotein-codingprotein-coding
Descriptiontransgelin-2SM22-alpha homologepididymis tissue protein Li 7epre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1
Modification date2018052220180519
UniProtAcc

P37802

P40424

Ensembl transtripts involved in fusion geneENST00000368096, ENST00000368097, 
ENST00000478033, ENST00000320307, 
ENST00000420696, ENST00000401534, 
ENST00000559240, ENST00000367897, 
ENST00000540236, ENST00000560641, 
ENST00000474046, ENST00000485769, 
ENST00000540246, 
Fusion gene scores* DoF score3 X 3 X 2=187 X 8 X 5=280
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAGLN2 [Title/Abstract] AND PBX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAGLN2

GO:0030855

epithelial cell differentiation

21492153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A3HO-01ATAGLN2chr1

159889064

-PBX1chr1

164651547

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368096ENST00000420696TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000401534TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000559240TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000367897TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000540236TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000560641TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-3UTRENST00000368096ENST00000474046TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000485769TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368096ENST00000540246TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000420696TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000401534TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000559240TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000367897TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000540236TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000560641TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-3UTRENST00000368097ENST00000474046TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000485769TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000368097ENST00000540246TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000420696TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000401534TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000559240TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000367897TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000540236TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000560641TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-3UTRENST00000478033ENST00000474046TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000485769TAGLN2chr1

159889064

-PBX1chr1

164651547

+
intron-intronENST00000478033ENST00000540246TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000420696TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000401534TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000559240TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000367897TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000540236TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000560641TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-3UTRENST00000320307ENST00000474046TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000485769TAGLN2chr1

159889064

-PBX1chr1

164651547

+
5CDS-intronENST00000320307ENST00000540246TAGLN2chr1

159889064

-PBX1chr1

164651547

+

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FusionProtFeatures for TAGLN2_PBX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAGLN2

P37802

PBX1

P40424

Binds the sequence 5'-ATCAATCAA-3'. Acts as atranscriptional activator of PF4 in complex with MEIS1. Convertedinto a potent transcriptional activator by the (1;19)translocation. May have a role in steroidogenesis and,subsequently, sexual development and differentiation. IsoformPBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinarcells is involved in the transcriptional activation of the ELA1enhancer; the complex binds to the enhancer B element andcooperates with the transcription factor 1 complex (PTF1) bound tothe enhancer A element. Probably in complex with MEIS2, isinvolved in transcriptional regulation by KLF4. Acts as atranscriptional activator of NKX2-5 and a transcriptionalrepressor of CDKN2B. Together with NKX2-5, it is required forspleen development through a mechanism that involves CDKN2Brepression (By similarity). {ECO:0000250,ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAGLN2_PBX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAGLN2_PBX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAGLN2VHL, EIF1B, EPB41, USP1, CDK2, APP, SSSCA1, AHCYL1, PPIA, IGBP1, CPLX1, DHX36, SNRPF, TOMM40, LIG4, MDC1, FN1, VCAM1, ATF2, ITGA4, LMNA, EHD2, RPA3, RPA2, RPA1, MOV10, NXF1, CUL7, OBSL1, TXNDC16, ACAA2, ALDOA, ALDOC, ARL8A, ATOX1, CARKD, CLIC3, CLIC4, CRIP1, DUT, ECI1, EEF2, ENO1, ENO2, ENO3, FABP3, FABP5, FABP7, FKBP1A, FKBP1B, GPX4, HSPE1, MTHFD1L, NUTF2, PHB, PIN1, PLS3, PMP2, PSAT1, RAB10, STIP1, ASS1, ATP5B, CACYBP, CFL1, COTL1, DAZAP1, EIF5A2, EIF5AL1, EZR, FKBP2, GDI1, GSTO1, GSTO2, HINT1, HSD17B10, HSDL2, HSPA4, HSPA4L, HSPH1, LTA4H, MSN, MTAP, NME1-NME2, NME2, PDIA3, PGAM1, PGK1, PPIL3, RAE1, RDX, SNX12, SNX3, SOD1, SPR, SUMO3, TAGLN3, TXN, UBE2C, TMEM189-UBE2V1, UBE2V1, UFC1, YKT6, TKT, TKTL2, UCHL3, HIST1H2BG, HSPA5, SLC33A1, TIGD6, BRD2, MCM2, U2AF2, CDC73, CDH1, DUSP22, DUSP28, DLST, DNM1L, TRIM25, TESPBX1MYH10, HOXB7, MEIS1, HOXA9, HOXD4, HOXD9, PKNOX1, HOXB1, HOXB8, NR3C1, MYOD1, MEIS2, HOXA10, SMARCA4, HDAC1, HDAC3, SIN3B, POU2F1, CREBBP, PDX1, ELAVL1, NEDD4L, HOXC8, KAT2A, MDM2, UCHL3, SMARCD3, LMX1B, MAGEA1, MAB21L1, MAB21L2, RBPJ, FOXA1, FOXC1, FOXE1, FOXQ1, TRAF1, FAM222A, VWA5A, C5orf24, CCDC120, C16orf71, ESR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAGLN2_PBX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTAGLN2P37802DB11638ArtenimolTransgelin-2small moleculeapproved|investigational

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RelatedDiseases for TAGLN2_PBX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAGLN2C0007134Renal Cell Carcinoma1CTD_human
HgeneTAGLN2C0023890Liver Cirrhosis1CTD_human
HgeneTAGLN2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTAGLN2C2239176Liver carcinoma1CTD_human
HgeneTAGLN2C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePBX1C0006413Burkitt Lymphoma2CTD_human
TgenePBX1C0236969Substance-Related Disorders1CTD_human