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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37137

FusionGeneSummary for TAGAP_CCSER2

check button Fusion gene summary
Fusion gene informationFusion gene name: TAGAP_CCSER2
Fusion gene ID: 37137
HgeneTgene
Gene symbol

TAGAP

CCSER2

Gene ID

117289

54462

Gene nameT cell activation RhoGTPase activating proteincoiled-coil serine rich protein 2
SynonymsARHGAP47|FKSG15|IDDM21|TAGAP1FAM190B|Gcap14|KIAA1128|bA486O22.1
Cytomap

6q25.3

10q23.1

Type of geneprotein-codingprotein-coding
DescriptionT-cell activation Rho GTPase-activating proteinserine-rich coiled-coil domain-containing protein 2family with sequence similarity 190, member Bprotein FAM190Bprotein GCAP14 homolog
Modification date2018052320180519
UniProtAcc

Q8N103

Q9H7U1

Ensembl transtripts involved in fusion geneENST00000367066, ENST00000326965, 
ENST00000338313, 
ENST00000359979, 
ENST00000372088, ENST00000224756, 
ENST00000494144, ENST00000543283, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 5 X 2=40
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TAGAP [Title/Abstract] AND CCSER2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK298686TAGAPchr6

159457064

-CCSER2chr10

86133674

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000367066ENST00000359979TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000367066ENST00000372088TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000367066ENST00000224756TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000367066ENST00000494144TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000367066ENST00000543283TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-3UTRENST00000326965ENST00000359979TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000326965ENST00000372088TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000326965ENST00000224756TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000326965ENST00000494144TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000326965ENST00000543283TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-3UTRENST00000338313ENST00000359979TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000338313ENST00000372088TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000338313ENST00000224756TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000338313ENST00000494144TAGAPchr6

159457064

-CCSER2chr10

86133674

+
intron-intronENST00000338313ENST00000543283TAGAPchr6

159457064

-CCSER2chr10

86133674

+

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FusionProtFeatures for TAGAP_CCSER2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAGAP

Q8N103

CCSER2

Q9H7U1

May function as a GTPase-activating protein and may playimportant roles during T-cell activation.{ECO:0000269|PubMed:15177553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAGAP_CCSER2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAGAP_CCSER2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAGAP_CCSER2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAGAP_CCSER2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAGAPC0003873Rheumatoid Arthritis2CTD_human
HgeneTAGAPC0010346Crohn Disease1CTD_human
HgeneTAGAPC0033860Psoriasis1CTD_human