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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37127

FusionGeneSummary for TAF7_EPC2

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF7_EPC2
Fusion gene ID: 37127
HgeneTgene
Gene symbol

TAF7

EPC2

Gene ID

6879

26122

Gene nameTATA-box binding protein associated factor 7enhancer of polycomb homolog 2
SynonymsTAF2F|TAFII55EPC-LIKE
Cytomap

5q31.3

2q23.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription initiation factor TFIID subunit 7RNA polymerase II TBP-associated factor subunit FTAF(II)55TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDaTAFII-55TATA box binding protein (TBP)-associated factor, RNA polyenhancer of polycomb homolog 2
Modification date2018052320180523
UniProtAcc

Q15545

Q52LR7

Ensembl transtripts involved in fusion geneENST00000313368, ENST00000258484, 
ENST00000409654, 
Fusion gene scores* DoF score3 X 3 X 1=911 X 10 X 2=220
# samples 412
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/220*10)=-0.874469117916141
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAF7 [Title/Abstract] AND EPC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAF7

GO:0000122

negative regulation of transcription by RNA polymerase II

11592977|16407123|18391197

HgeneTAF7

GO:0006352

DNA-templated transcription, initiation

9603525

HgeneTAF7

GO:0006366

transcription by RNA polymerase II

7824954

HgeneTAF7

GO:0006367

transcription initiation from RNA polymerase II promoter

9603525|16407123

HgeneTAF7

GO:0006469

negative regulation of protein kinase activity

18391197

HgeneTAF7

GO:0035067

negative regulation of histone acetylation

11592977

HgeneTAF7

GO:0045892

negative regulation of transcription, DNA-templated

11592977|16407123|18391197

HgeneTAF7

GO:0045944

positive regulation of transcription by RNA polymerase II

12676957


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE837002TAF7chr5

140700249

+EPC2chr2

149526741

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000313368ENST00000258484TAF7chr5

140700249

+EPC2chr2

149526741

+
intron-intronENST00000313368ENST00000409654TAF7chr5

140700249

+EPC2chr2

149526741

+

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FusionProtFeatures for TAF7_EPC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAF7

Q15545

EPC2

Q52LR7

Functions as a component of the DNA-binding generaltranscription factor complex TFIID, a multimeric protein complexthat plays a central role in mediating promoter responses tovarious activators and repressors. Present in both of thepreviously described TFIID species which either lack or containTAFII30 (TFIID alpha and TFIID beta respectively).{ECO:0000269|PubMed:10438527}. May play a role in transcription or DNA repair.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAF7_EPC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAF7_EPC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAF7_EPC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAF7_EPC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource