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Fusion gene ID: 37110 |
FusionGeneSummary for TAF4_CDH4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAF4_CDH4 | Fusion gene ID: 37110 | Hgene | Tgene | Gene symbol | TAF4 | CDH4 | Gene ID | 6874 | 1002 |
| Gene name | TATA-box binding protein associated factor 4 | cadherin 4 | |
| Synonyms | TAF2C|TAF2C1|TAF4A|TAFII130|TAFII135 | CAD4|R-CAD|RCAD | |
| Cytomap | 20q13.33 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit CTAF(II)130TAF(II)135TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDaTAF4A RNA polymerase II, TATA box binding protein (TBP | cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00268 | P55283 | |
| Ensembl transtripts involved in fusion gene | ENST00000252996, ENST00000609045, | ENST00000360469, ENST00000543233, | |
| Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 10 X 6 X 6=360 |
| # samples | 13 | 10 | |
| ** MAII score | log2(13/250*10)=-0.943416471633632 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAF4 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAF4 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
| Hgene | TAF4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
| Hgene | TAF4 | GO:0045893 | positive regulation of transcription, DNA-templated | 12771217 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A7-A13F-01A | TAF4 | chr20 | 60639507 | - | CDH4 | chr20 | 59829882 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000252996 | ENST00000360469 | TAF4 | chr20 | 60639507 | - | CDH4 | chr20 | 59829882 | + |
| 5CDS-intron | ENST00000252996 | ENST00000543233 | TAF4 | chr20 | 60639507 | - | CDH4 | chr20 | 59829882 | + |
| intron-3CDS | ENST00000609045 | ENST00000360469 | TAF4 | chr20 | 60639507 | - | CDH4 | chr20 | 59829882 | + |
| intron-intron | ENST00000609045 | ENST00000543233 | TAF4 | chr20 | 60639507 | - | CDH4 | chr20 | 59829882 | + |
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FusionProtFeatures for TAF4_CDH4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAF4 | CDH4 |
| Part of the TFIID complex, a multimeric protein complexthat plays a central role in mediating promoter responses tovarious activators and repressors. Potentiates transcriptionalactivation by the AF-2S of the retinoic acid, vitamin D3 andthyroid hormone. | Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May play an important role inretinal development. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 142_148 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
| Hgene | TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 270_277 | 453 | 1086 | Compositional bias | Note=Poly-Pro |
| Hgene | TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 333_339 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
| Hgene | TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 39_42 | 453 | 1086 | Compositional bias | Note=Poly-His |
| Hgene | TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 52_57 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
| Hgene | TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 98_101 | 453 | 1086 | Compositional bias | Note=Poly-Gly |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 873_888 | 19 | 917 | Compositional bias | Note=Ser-rich |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 873_888 | -89 | 843 | Compositional bias | Note=Ser-rich |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 170_277 | 19 | 917 | Domain | Cadherin 1 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 278_392 | 19 | 917 | Domain | Cadherin 2 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 393_507 | 19 | 917 | Domain | Cadherin 3 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 508_613 | 19 | 917 | Domain | Cadherin 4 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 614_724 | 19 | 917 | Domain | Cadherin 5 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 170_277 | -89 | 843 | Domain | Cadherin 1 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 278_392 | -89 | 843 | Domain | Cadherin 2 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 393_507 | -89 | 843 | Domain | Cadherin 3 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 508_613 | -89 | 843 | Domain | Cadherin 4 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 614_724 | -89 | 843 | Domain | Cadherin 5 |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 170_734 | 19 | 917 | Topological domain | Extracellular |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 757_916 | 19 | 917 | Topological domain | Cytoplasmic |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 170_734 | -89 | 843 | Topological domain | Extracellular |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 757_916 | -89 | 843 | Topological domain | Cytoplasmic |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000360469 | + | 0 | 16 | 735_756 | 19 | 917 | Transmembrane | Helical |
| Tgene | >CDH4 | chr20:60639507 | chr20:59829882 | ENST00000543233 | + | 0 | 15 | 735_756 | -89 | 843 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 682_685 | 453 | 1086 | Compositional bias | Note=Poly-Pro |
| Hgene | >TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 810_815 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
| Hgene | >TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 830_833 | 453 | 1086 | Compositional bias | Note=Poly-Asp |
| Hgene | >TAF4 | chr20:60639507 | chr20:59829882 | ENST00000252996 | - | 1 | 15 | 590_687 | 453 | 1086 | Domain | TAFH |
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FusionGeneSequence for TAF4_CDH4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TAF4_ENST00000252996_chr20_60639507_-_CDH4_ENST00000360469_chr20_59829882_+_1351aa MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPP PAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAP PPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQT LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQ LPPGPXXGSYNXRDLQGWVLXRXLHGINLPKYSRRGKATSSQVQQLCGDQGDTIXDQQHGLQSWGRWDSLRHPGAAGPLRAGGVHGDCMG QPDSREMGRRGAVAGGPDLVPALWTQAAERKEGRGSGPLSASEGHPAAVAPAPERQRAEAAQTGLGHPAHQRARELARALPAAAREDPVR QRQXHPHPVQHHGSGRRPAPHGGLQHXLHVRPDVRHKAHGPGGARLLPPPSPRCGHEWQQGGEPHRPVHLRHRHEXQPPXVHQPGLQRLR GRGLQARHLRDDRHGQRCXRQHHGQRDGAVPDRDPDPTEPVPEYVHHQQRDWRYRHSGGWPGPRESSAVHSHRSGHRYGRKSQLWPLKHS HSHHHGDRCEXQPARIYRQHVCRGGPRKPRGDRGRKPHGDGPRSAPLSKLECRLPHHQWGSIRALQRPHRPRNQRGHGHRGEGSRLRAQQ SFHADSDGVQPGAPGQRNPDVLPVHGRGDHLHHGHQRGSLLPLKPQADPPGGGRAPRHRADHVFSCGPXPVHAAGCEILKAVRPSELAAH QCHQRPDHHGGSAGPXVPLHQKQRLRGHLPGSXQWDTPGQRHRDPPDLSHXHQRQRPXAAAQGGADLREAQPERHQHHGGRRXRRPQHRP LRLRAALCPGGRAEELDHHPPERXLCPTQLAHPVPGGRDVXRPHHRHRLWKPSPVQHVHHQSQGVPMXXQRGLHHHWRSGSGWSGHRCHR GHPHLHPHPADHGPAVCHVDEAAREGAPHEAAAHXPRGRRPRQHPQVXRGRRWRGGPGLRPQPAAAAGSHGARAKQSPWRASRGXAAGGR XAPVPDQAHGAAPRRHRXLHQXGTPRCXQRPHGTPLXLPAGLRLRGERLHRRLRQLPELIQFRGPRLRLPQRLGAQIQEAGGHVWRWXRG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TAF4_ENST00000252996_chr20_60639507_-_CDH4_ENST00000360469_chr20_59829882_+_4054nt ATGGCGGCGGGCTCGGATCTGCTGGACGAGGTCTTCTTCAACAGCGAGGTGGACGAGAAAGTGGTGAGCGACCTGGTGGGCTCGCTGGAG TCGCAGCTGGCGGCCAGCGCGGCCCACCACCACCACCTCGCGCCGCGCACGCCCGAGGTGCGGGCCGCGGCCGCCGGCGCGCTCGGGAAC CATGTTGTGAGCGGCAGCCCGGCCGGAGCCGCGGGCGCAGGGCCGGCCGCCCCCGCCGAGGGCGCGCCCGGAGCGGCGCCGGAGCCGCCC CCCGCAGGTAGAGCGCGGCCGGGGGGCGGGGGGCCGCAGCGCCCGGGCCCCCCCTCACCGCGCCGCCCCCTTGTCCCCGCAGGGCCCGCG CCGCCCGCCGCGAAGCTGAGGCCGCCGCCCGAGGGCAGCGCGGGGTCCTGCGCCCCGGTGCCCGCCGCCGCCGCCGTCGCCGCGGGGCCC GAGCCCGCCCCCGCCGGCCCCGCCAAGCCCGCCGGCCCCGCCGCGCTGGCCGCCCGCGCCGGCCCCGGCCCCGGGCCCGGCCCCGGCCCC GGCCCCGGCCCTGGCCCTGGCAAGCCCGCCGGCCCCGGCGCCGCGCAAACTTTGAATGGGAGCGCCGCGCTGCTGAACTCGCACCACGCC GCCGCACCTGCTGTCAGCCTGGTCAACAACGGGCCCGCCGCGCTGCTGCCGCTGCCCAAGCCCGCCGCCCCCGGCACTGTCATCCAGACG CCCCCCTTCGTGGGCGCCGCCGCGCCCCCCGCGCCCGCCGCGCCCTCGCCCCCCGCCGCCCCCGCGCCCGCCGCCCCCGCCGCCGCCCCG CCCCCGCCACCCCCCGCGCCCGCCACTCTGGCCCGGCCGCCCGGCCACCCCGCCGGACCCCCGACCGCCGCGCCCGCCGTGCCGCCCCCC GCCGCCGCCCAGAACGGGGGCAGCGCCGGGGCAGCCCCCGCCCCCGCCCCGGCCGCCGGGGGCCCCGCGGGGGTCAGCGGCCAACCCGGG CCCGGCGCGGCGGCTGCGGCGCCGGCGCCGGGGGTCAAGGCCGAGTCGCCCAAGAGGGTGGTGCAGGCGGCGCCCCCGGCGGCGCAGACC CTGGCGGCCAGCGGCCCGGCCAGCACGGCGGCCAGCATGGTCATCGGGCCAACTATGCAAGGGGCGCTGCCCAGCCCGGCCGCCGTCCCG CCGCCCGCCCCCGGGACCCCCACCGGGCTGCCCAAAGGCGCGGCCGGCGCAGTGACCCAGAGCCTGTCCCGGACGCCCACGGCCACCACC AGCGGGATTCGGGCCACCCTGACGCCCACCGTGCTGGCCCCCCGCTTGCCGCAGCCGCCTCAGAACCCGACCAACATCCAGAACTTCCAG CTGCCCCCAGGCCCATAATGAGGATCTTACAACTAGAGAGACCTGCAAGGCTGGGTTCTCTGAAGATGATTACACGGCATTAATCTCCCA AAATATTCTAGAAGGGGAAAAGCTACTTCAAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGA CTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGA CAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGG AAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCG GCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGA CAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTC CGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAA GGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGT GGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTA CCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGG CCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAACACAGC CACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAACCGCGT GGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAGTGGGGA TCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCTCAACAG AGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGTGACCAT CTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCACCGTGCT GACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCTGCACAT CAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCACCTTCCT GGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCT GCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCC CTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTT GCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCAT CAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGT GGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAA GCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGA CCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGC TGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGA CCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATC CAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TAF4_ENST00000252996_chr20_60639507_-_CDH4_ENST00000360469_chr20_59829882_+_7726nt ATGGCGGCGGGCTCGGATCTGCTGGACGAGGTCTTCTTCAACAGCGAGGTGGACGAGAAAGTGGTGAGCGACCTGGTGGGCTCGCTGGAG TCGCAGCTGGCGGCCAGCGCGGCCCACCACCACCACCTCGCGCCGCGCACGCCCGAGGTGCGGGCCGCGGCCGCCGGCGCGCTCGGGAAC CATGTTGTGAGCGGCAGCCCGGCCGGAGCCGCGGGCGCAGGGCCGGCCGCCCCCGCCGAGGGCGCGCCCGGAGCGGCGCCGGAGCCGCCC CCCGCAGGTAGAGCGCGGCCGGGGGGCGGGGGGCCGCAGCGCCCGGGCCCCCCCTCACCGCGCCGCCCCCTTGTCCCCGCAGGGCCCGCG CCGCCCGCCGCGAAGCTGAGGCCGCCGCCCGAGGGCAGCGCGGGGTCCTGCGCCCCGGTGCCCGCCGCCGCCGCCGTCGCCGCGGGGCCC GAGCCCGCCCCCGCCGGCCCCGCCAAGCCCGCCGGCCCCGCCGCGCTGGCCGCCCGCGCCGGCCCCGGCCCCGGGCCCGGCCCCGGCCCC GGCCCCGGCCCTGGCCCTGGCAAGCCCGCCGGCCCCGGCGCCGCGCAAACTTTGAATGGGAGCGCCGCGCTGCTGAACTCGCACCACGCC GCCGCACCTGCTGTCAGCCTGGTCAACAACGGGCCCGCCGCGCTGCTGCCGCTGCCCAAGCCCGCCGCCCCCGGCACTGTCATCCAGACG CCCCCCTTCGTGGGCGCCGCCGCGCCCCCCGCGCCCGCCGCGCCCTCGCCCCCCGCCGCCCCCGCGCCCGCCGCCCCCGCCGCCGCCCCG CCCCCGCCACCCCCCGCGCCCGCCACTCTGGCCCGGCCGCCCGGCCACCCCGCCGGACCCCCGACCGCCGCGCCCGCCGTGCCGCCCCCC GCCGCCGCCCAGAACGGGGGCAGCGCCGGGGCAGCCCCCGCCCCCGCCCCGGCCGCCGGGGGCCCCGCGGGGGTCAGCGGCCAACCCGGG CCCGGCGCGGCGGCTGCGGCGCCGGCGCCGGGGGTCAAGGCCGAGTCGCCCAAGAGGGTGGTGCAGGCGGCGCCCCCGGCGGCGCAGACC CTGGCGGCCAGCGGCCCGGCCAGCACGGCGGCCAGCATGGTCATCGGGCCAACTATGCAAGGGGCGCTGCCCAGCCCGGCCGCCGTCCCG CCGCCCGCCCCCGGGACCCCCACCGGGCTGCCCAAAGGCGCGGCCGGCGCAGTGACCCAGAGCCTGTCCCGGACGCCCACGGCCACCACC AGCGGGATTCGGGCCACCCTGACGCCCACCGTGCTGGCCCCCCGCTTGCCGCAGCCGCCTCAGAACCCGACCAACATCCAGAACTTCCAG CTGCCCCCAGGCCCATAATGAGGATCTTACAACTAGAGAGACCTGCAAGGCTGGGTTCTCTGAAGATGATTACACGGCATTAATCTCCCA AAATATTCTAGAAGGGGAAAAGCTACTTCAAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGA CTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGA CAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGG AAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCG GCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGA CAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTC CGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAA GGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGT GGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTA CCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGG CCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAACACAGC CACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAACCGCGT GGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAGTGGGGA TCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCTCAACAG AGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGTGACCAT CTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCACCGTGCT GACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCTGCACAT CAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCACCTTCCT GGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCT GCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCC CTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTT GCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCAT CAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGT GGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAA GCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGA CCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGC TGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGA CCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATC CAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGA TTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGAC TCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAGCGCCCT GCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGC ACTGTTTTTAAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATTCCCTCA AACTCAGGAGTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAAGGCATC ATTCAGAAATGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTTGAAAAC AGAGTGGGGTTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAGGCTTAG CCCTTCAGCCCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATGCTGTGA GGAGCTCAGGCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGACACCTGT CACCCTGAGTGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTCCAACCC TGGCGACCAGACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAACCATCCG GAGGGCTGTGCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACACACCCAG CAGCCTGCGAAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCCCGTCTT GCCGTGCCTACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCAGCGGCC GGGTCCAAACTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATTGGTTCT GCAGGACAGTGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGGGTGCAT TCTCCCTCTGGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAGCTTTCT GTCTCTCCCAGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAGGGCGGT GCCAGCACTGGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCTTTGGGG GCAGCATGAGCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACAGCTTTG GCCTTGAGTGCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTGCCCCTG TGCAGCCTTCAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTTCACTGT GCCACGTGCTGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCACCGGGG TCCCCGAGTTCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTAGTGGAA GGACTGGAAATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATGGCCCGG GAGCCAGGGCAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACCCAGCAC CAGGAGACCCCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTCGCCCAC AGCCTCTTGTCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCATAGGGCT TCCTGTGCCCATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGATGGGGTT CCTGCACCTTCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAGCTTGTA GATACGACTGCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCTTTAGGG AATTTTTGTTTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCAGCCTAG GGCCACAGTCCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAAATGCTA GGCCTCCTGCCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGCCGACAC ACACAGTCCACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAAAGGAAT AACACCAAAAGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCTCACAAC AGGCCCAGCGGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTTGCATGT TTCTTTTTGAAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCACACCTGC AAATCTGAGCATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCATTTTGT ACCAAAAAAAAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACTCAGTAG |
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FusionGenePPI for TAF4_CDH4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAF4 | TBP, CBX5, TAF1, GTF2A2, TAF4, TAF12, TAF8, TAF5, KAT2A, SUPT3H, TAF10, CREM, SP1, TAF9, TAF13, TBPL1, GTF2A1, ATF7, CREB1, TCF12, ELAVL1, TAF6, TAF7, TRRAP, TAF3, TAF9B, TAF1L, AHR, HTT, JUN, GTF2F2, HIST3H3, MED26, FBXO6, SOX6, EGFR, NUP50, ANAPC1, ANAPC7, CDC16, NAP1L4, ANAPC13, CDC23, CDC27, NCL, SF3B3, EWSR1, HIST1H3E, KIFAP3, TAF7L, TAF11 | CDH4 | CDH2, CDK5RAP3, FUS, UBE2I, CTNNA3, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF4_CDH4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF4_CDH4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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