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Fusion gene ID: 37083 |
FusionGeneSummary for TAF1A_SLC12A7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAF1A_SLC12A7 | Fusion gene ID: 37083 | Hgene | Tgene | Gene symbol | TAF1A | SLC12A7 | Gene ID | 9015 | 10723 |
| Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit A | solute carrier family 12 member 7 | |
| Synonyms | MGC:17061|RAFI48|SL1|TAFI48 | KCC4 | |
| Cytomap | 1q41 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TATA box-binding protein-associated factor RNA polymerase I subunit ARNA polymerase I-specific TBP-associated factor 48 kDaSL1, 48kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDTATA box binding protein (TBP)-assoc | solute carrier family 12 member 7K-Cl cotransporter 4SUCO/SLC12A7 fusionelectroneutral potassium-chloride cotransporter 4potassium/chloride transporter KCC4solute carrier family 12 (potassium/chloride transporter), member 7solute carrier family 12 ( | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q15573 | Q9Y666 | |
| Ensembl transtripts involved in fusion gene | ENST00000366890, ENST00000350027, ENST00000352967, ENST00000391882, ENST00000543857, ENST00000465263, | ENST00000264930, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAF1A [Title/Abstract] AND SLC12A7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-DQ-7589-01A | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000366890 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| Frame-shift | ENST00000350027 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| In-frame | ENST00000352967 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| intron-3CDS | ENST00000391882 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| In-frame | ENST00000543857 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| 5UTR-3CDS | ENST00000465263 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
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FusionProtFeatures for TAF1A_SLC12A7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAF1A | SLC12A7 |
| Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}. | Mediates electroneutral potassium-chloride cotransportwhen activated by cell swelling. May mediate K(+) uptake intoDeiters' cells in the cochlea and contribute to K(+) recycling inthe inner ear. Important for the survival of cochlear outer andinner hair cells and the maintenance of the organ of Corti. May berequired for basolateral Cl(-) extrusion in the kidney andcontribute to renal acidification (By similarity). {ECO:0000250,ECO:0000269|PubMed:10913127}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF1A_SLC12A7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TAF1A_ENST00000352967_chr1_222757470_-_SLC12A7_ENST00000264930_chr5_1085588_-_956aa MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSY KRQAAPETYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVC LLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDV WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVL >In-frame_TAF1A_ENST00000543857_chr1_222757470_-_SLC12A7_ENST00000264930_chr5_1085588_-_956aa MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSY KRQAAPETYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVC LLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDV WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TAF1A_ENST00000352967_chr1_222757470_-_SLC12A7_ENST00000264930_chr5_1085588_-_2868nt ATGAGTGATTTCAGTGAAGAATTAAAAGGGCCTGTGACAGATGATGAAGAAGTGGAAACATCTGTGCTCAGTGGTGCAGGAATGCATTTT CCTTGGCTTCAAACATACGTAGAAACTGTGGCCATTGGAGGGAAAAGGAGGAAGGATTTTGCTCAGACAACAAGTGCTTGTTTAAGTTTT ATCCAAGAAGCTCTGCTGAAGCACCAATGGCAGCAAGCTGCAGAATACATGTACAGTTATTTTCAGACCTTGGAAGATTCAGATAGCTAC AAAAGGCAGGCTGCACCTGAGACGTACATCTCCCCGGGTGCGGCCATCTTCCAGGCGGAGGCTGCAGGTGGCGAGGCGGCCGCCATGCTG CACAACATGCGTGTGTACGGCACGTGCACGCTCGTGCTCATGGCCCTGGTGGTCTTCGTGGGCGTCAAGTATGTCAACAAGCTGGCGCTG GTCTTCCTGGCCTGCGTCGTGCTGTCCATCCTGGCCATCTATGCCGGCGTCATCAAGTCTGCCTTCGACCCCCCGGACATCCCGGTCTGC CTCCTGGGGAACCGCACGCTGTCACGGCGCAGCTTCGATGCCTGCGTCAAGGCCTACGGCATCCACAACAACTCAGCCACCTCCGCGCTC TGGGGCCTCTTCTGCAACGGCTCCCAGCCCAGCGCCGCCTGTGACGAGTACTTCATCCAGAACAACGTCACCGAAATCCAGGGCATCCCG GGCGCGGCCAGTGGTGTCTTCCTGGAGAACCTGTGGAGTACGTACGCGCACGCGGGGGCGTTTGTGGAGAAGAAAGGTGTGCCCTCGGTG CCCGTGGCAGAGGAGAGCCGTGCCAGCGCACTGCCCTACGTGCTCACCGACATCGCGGCCTCCTTCACCCTGCTGGTTGGCATCTACTTC CCTTCCGTGACCGGTATCATGGCGGGTTCAAACCGGTCCGGGGACCTCAAGGATGCACAGAAGTCCATCCCCACGGGGACCATCCTGGCC ATAGTGACGACGTCTTTCATCTATCTCTCCTGCATTGTGCTGTTTGGGGCCTGCATTGAAGGCGTGGTCTTACGAGATAAGTTCGGGGAG GCCCTGCAGGGGAACCTGGTCATCGGCATGCTGGCCTGGCCCTCCCCCTGGGTCATCGTCATCGGCTCCTTCTTCTCCACCTGCGGTGCC GGCCTGCAGAGCCTCACGGGGGCACCGCGCCTACTGCAGGCCATTGCCCGTGACGGCATCGTCCCCTTCCTGCAGGTGTTTGGCCACGGG AAGGCCAACGGGGAGCCCACGTGGGCGCTGCTGCTGACAGTCCTCATCTGCGAGACTGGCATCCTCATCGCCTCTCTGGACAGCGTGGCC CCGATCCTCTCCATGTTCTTCCTCATGTGCTACCTGTTCGTGAACCTGGCCTGCGCCGTGCAGACCCTGCTACGTACCCCCAACTGGCGT CCACGCTTCAAGTTCTACCACTGGACCCTGTCCTTTCTGGGTATGAGCCTGTGCCTGGCGCTGATGTTCATCTGCTCCTGGTACTACGCG CTGTCCGCCATGCTCATCGCTGGCTGCATCTACAAGTACATCGAGTACCGCGGGGCCGAGAAGGAGTGGGGCGATGGCATCCGTGGCCTA TCCCTGAACGCCGCCCGCTACGCCCTGCTGCGCGTGGAGCACGGTCCCCCCCACACCAAGAACTGGAGGCCCCAGGTGCTGGTGATGCTG AACCTGGACGCGGAGCAGGCCGTGAAGCACCCCCGCCTGCTGTCCTTCACGTCGCAGCTGAAGGCCGGCAAGGGCCTGACCATCGTGGGC TCGGTGCTGGAGGGGACGTACCTGGACAAGCACATGGAGGCTCAGCGGGCCGAGGAGAACATACGGTCCCTAATGAGCACAGAGAAGACC AAGGGCTTCTGCCAGCTGGTGGTCTCGTCCAGCCTGCGGGATGGCATGTCCCACCTGATCCAGTCGGCCGGCCTGGGCGGCCTGAAGCAC AACACGGTGCTCATGGCCTGGCCCGCATCCTGGAAGCAGGAGGACAACCCCTTCTCCTGGAAGAACTTTGTGGACACCGTCCGCGACACC ACCGCCGCGCACCAGGCTCTGCTGGTGGCCAAGAACGTCGACTCGTTTCCGCAAAACCAGGAGCGCTTCGGCGGGGGCCACATCGACGTG TGGTGGATCGTGCACGACGGCGGCATGCTCATGCTGCTGCCCTTCCTGCTGCGCCAGCACAAGGTGTGGAGGAAGTGCCGGATGCGTATC TTCACCGTGGCCCAGGTGGACGACAACAGCATCCAGATGAAGAAGGACCTGCAGATGTTCTTGTACCACTTGCGCATCAGCGCCGAGGTG GAGGTGGTGGAGATGGTTGAAAACGACATATCTGCTTTCACCTACGAGAGGACACTAATGATGGAGCAGAGGTCGCAGATGCTGAAGCAG ATGCAGCTGTCCAAGAACGAGCAGGAGCGAGAGGCCCAGCTGATCCACGACAGGAACACCGCGTCCCACACCGCGGCGGCAGCCAGGACC CAAGCGCCGCCTACGCCAGACAAGGTGCAGATGACCTGGACCAGGGAGAAGCTGATCGCTGAGAAGTACAGGAGCAGAGACACCAGCCTA TCTGGTTTCAAAGACCTCTTCAGCATGAAGCCGGACCAGTCCAACGTCAGGCGGATGCACACGGCTGTGAAGCTCAATGGCGTCGTCCTC AACAAGTCCCAGGATGCGCAGCTGGTCCTGCTCAACATGCCAGGTCCTCCCAAAAACCGGCAGGGAGACGAGAACTACATGGAGTTTCTT >In-frame_TAF1A_ENST00000543857_chr1_222757470_-_SLC12A7_ENST00000264930_chr5_1085588_-_2868nt ATGAGTGATTTCAGTGAAGAATTAAAAGGGCCTGTGACAGATGATGAAGAAGTGGAAACATCTGTGCTCAGTGGTGCAGGAATGCATTTT CCTTGGCTTCAAACATACGTAGAAACTGTGGCCATTGGAGGGAAAAGGAGGAAGGATTTTGCTCAGACAACAAGTGCTTGTTTAAGTTTT ATCCAAGAAGCTCTGCTGAAGCACCAATGGCAGCAAGCTGCAGAATACATGTACAGTTATTTTCAGACCTTGGAAGATTCAGATAGCTAC AAAAGGCAGGCTGCACCTGAGACGTACATCTCCCCGGGTGCGGCCATCTTCCAGGCGGAGGCTGCAGGTGGCGAGGCGGCCGCCATGCTG CACAACATGCGTGTGTACGGCACGTGCACGCTCGTGCTCATGGCCCTGGTGGTCTTCGTGGGCGTCAAGTATGTCAACAAGCTGGCGCTG GTCTTCCTGGCCTGCGTCGTGCTGTCCATCCTGGCCATCTATGCCGGCGTCATCAAGTCTGCCTTCGACCCCCCGGACATCCCGGTCTGC CTCCTGGGGAACCGCACGCTGTCACGGCGCAGCTTCGATGCCTGCGTCAAGGCCTACGGCATCCACAACAACTCAGCCACCTCCGCGCTC TGGGGCCTCTTCTGCAACGGCTCCCAGCCCAGCGCCGCCTGTGACGAGTACTTCATCCAGAACAACGTCACCGAAATCCAGGGCATCCCG GGCGCGGCCAGTGGTGTCTTCCTGGAGAACCTGTGGAGTACGTACGCGCACGCGGGGGCGTTTGTGGAGAAGAAAGGTGTGCCCTCGGTG CCCGTGGCAGAGGAGAGCCGTGCCAGCGCACTGCCCTACGTGCTCACCGACATCGCGGCCTCCTTCACCCTGCTGGTTGGCATCTACTTC CCTTCCGTGACCGGTATCATGGCGGGTTCAAACCGGTCCGGGGACCTCAAGGATGCACAGAAGTCCATCCCCACGGGGACCATCCTGGCC ATAGTGACGACGTCTTTCATCTATCTCTCCTGCATTGTGCTGTTTGGGGCCTGCATTGAAGGCGTGGTCTTACGAGATAAGTTCGGGGAG GCCCTGCAGGGGAACCTGGTCATCGGCATGCTGGCCTGGCCCTCCCCCTGGGTCATCGTCATCGGCTCCTTCTTCTCCACCTGCGGTGCC GGCCTGCAGAGCCTCACGGGGGCACCGCGCCTACTGCAGGCCATTGCCCGTGACGGCATCGTCCCCTTCCTGCAGGTGTTTGGCCACGGG AAGGCCAACGGGGAGCCCACGTGGGCGCTGCTGCTGACAGTCCTCATCTGCGAGACTGGCATCCTCATCGCCTCTCTGGACAGCGTGGCC CCGATCCTCTCCATGTTCTTCCTCATGTGCTACCTGTTCGTGAACCTGGCCTGCGCCGTGCAGACCCTGCTACGTACCCCCAACTGGCGT CCACGCTTCAAGTTCTACCACTGGACCCTGTCCTTTCTGGGTATGAGCCTGTGCCTGGCGCTGATGTTCATCTGCTCCTGGTACTACGCG CTGTCCGCCATGCTCATCGCTGGCTGCATCTACAAGTACATCGAGTACCGCGGGGCCGAGAAGGAGTGGGGCGATGGCATCCGTGGCCTA TCCCTGAACGCCGCCCGCTACGCCCTGCTGCGCGTGGAGCACGGTCCCCCCCACACCAAGAACTGGAGGCCCCAGGTGCTGGTGATGCTG AACCTGGACGCGGAGCAGGCCGTGAAGCACCCCCGCCTGCTGTCCTTCACGTCGCAGCTGAAGGCCGGCAAGGGCCTGACCATCGTGGGC TCGGTGCTGGAGGGGACGTACCTGGACAAGCACATGGAGGCTCAGCGGGCCGAGGAGAACATACGGTCCCTAATGAGCACAGAGAAGACC AAGGGCTTCTGCCAGCTGGTGGTCTCGTCCAGCCTGCGGGATGGCATGTCCCACCTGATCCAGTCGGCCGGCCTGGGCGGCCTGAAGCAC AACACGGTGCTCATGGCCTGGCCCGCATCCTGGAAGCAGGAGGACAACCCCTTCTCCTGGAAGAACTTTGTGGACACCGTCCGCGACACC ACCGCCGCGCACCAGGCTCTGCTGGTGGCCAAGAACGTCGACTCGTTTCCGCAAAACCAGGAGCGCTTCGGCGGGGGCCACATCGACGTG TGGTGGATCGTGCACGACGGCGGCATGCTCATGCTGCTGCCCTTCCTGCTGCGCCAGCACAAGGTGTGGAGGAAGTGCCGGATGCGTATC TTCACCGTGGCCCAGGTGGACGACAACAGCATCCAGATGAAGAAGGACCTGCAGATGTTCTTGTACCACTTGCGCATCAGCGCCGAGGTG GAGGTGGTGGAGATGGTTGAAAACGACATATCTGCTTTCACCTACGAGAGGACACTAATGATGGAGCAGAGGTCGCAGATGCTGAAGCAG ATGCAGCTGTCCAAGAACGAGCAGGAGCGAGAGGCCCAGCTGATCCACGACAGGAACACCGCGTCCCACACCGCGGCGGCAGCCAGGACC CAAGCGCCGCCTACGCCAGACAAGGTGCAGATGACCTGGACCAGGGAGAAGCTGATCGCTGAGAAGTACAGGAGCAGAGACACCAGCCTA TCTGGTTTCAAAGACCTCTTCAGCATGAAGCCGGACCAGTCCAACGTCAGGCGGATGCACACGGCTGTGAAGCTCAATGGCGTCGTCCTC AACAAGTCCCAGGATGCGCAGCTGGTCCTGCTCAACATGCCAGGTCCTCCCAAAAACCGGCAGGGAGACGAGAACTACATGGAGTTTCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TAF1A_ENST00000352967_chr1_222757470_-_SLC12A7_ENST00000264930_chr5_1085588_-_5033nt GCCAACGATACGCCTGCTGCAGCAGGAGGAGTTACGAGCCGGGCCGCGCGCTGCCTAAATACCTAAACCAGGTTTAGCGCCTGCTCATAT AAAGCTCTCCTAACTCGTCTTCCGGTGGGAATTTCTTCACGTGGGCCGGAGTCGGAGACTGAGTTTAGCTTTACTGAGGAGCTCTAAATT TAGGCGGGTATGAGTGATTTCAGTGAAGAATTAAAAGGGCCTGTGACAGATGATGAAGAAGTGGAAACATCTGTGCTCAGTGGTGCAGGA ATGCATTTTCCTTGGCTTCAAACATACGTAGAAACTGTGGCCATTGGAGGGAAAAGGAGGAAGGATTTTGCTCAGACAACAAGTGCTTGT TTAAGTTTTATCCAAGAAGCTCTGCTGAAGCACCAATGGCAGCAAGCTGCAGAATACATGTACAGTTATTTTCAGACCTTGGAAGATTCA GATAGCTACAAAAGGCAGGCTGCACCTGAGACGTACATCTCCCCGGGTGCGGCCATCTTCCAGGCGGAGGCTGCAGGTGGCGAGGCGGCC GCCATGCTGCACAACATGCGTGTGTACGGCACGTGCACGCTCGTGCTCATGGCCCTGGTGGTCTTCGTGGGCGTCAAGTATGTCAACAAG CTGGCGCTGGTCTTCCTGGCCTGCGTCGTGCTGTCCATCCTGGCCATCTATGCCGGCGTCATCAAGTCTGCCTTCGACCCCCCGGACATC CCGGTCTGCCTCCTGGGGAACCGCACGCTGTCACGGCGCAGCTTCGATGCCTGCGTCAAGGCCTACGGCATCCACAACAACTCAGCCACC TCCGCGCTCTGGGGCCTCTTCTGCAACGGCTCCCAGCCCAGCGCCGCCTGTGACGAGTACTTCATCCAGAACAACGTCACCGAAATCCAG GGCATCCCGGGCGCGGCCAGTGGTGTCTTCCTGGAGAACCTGTGGAGTACGTACGCGCACGCGGGGGCGTTTGTGGAGAAGAAAGGTGTG CCCTCGGTGCCCGTGGCAGAGGAGAGCCGTGCCAGCGCACTGCCCTACGTGCTCACCGACATCGCGGCCTCCTTCACCCTGCTGGTTGGC ATCTACTTCCCTTCCGTGACCGGTATCATGGCGGGTTCAAACCGGTCCGGGGACCTCAAGGATGCACAGAAGTCCATCCCCACGGGGACC ATCCTGGCCATAGTGACGACGTCTTTCATCTATCTCTCCTGCATTGTGCTGTTTGGGGCCTGCATTGAAGGCGTGGTCTTACGAGATAAG TTCGGGGAGGCCCTGCAGGGGAACCTGGTCATCGGCATGCTGGCCTGGCCCTCCCCCTGGGTCATCGTCATCGGCTCCTTCTTCTCCACC TGCGGTGCCGGCCTGCAGAGCCTCACGGGGGCACCGCGCCTACTGCAGGCCATTGCCCGTGACGGCATCGTCCCCTTCCTGCAGGTGTTT GGCCACGGGAAGGCCAACGGGGAGCCCACGTGGGCGCTGCTGCTGACAGTCCTCATCTGCGAGACTGGCATCCTCATCGCCTCTCTGGAC AGCGTGGCCCCGATCCTCTCCATGTTCTTCCTCATGTGCTACCTGTTCGTGAACCTGGCCTGCGCCGTGCAGACCCTGCTACGTACCCCC AACTGGCGTCCACGCTTCAAGTTCTACCACTGGACCCTGTCCTTTCTGGGTATGAGCCTGTGCCTGGCGCTGATGTTCATCTGCTCCTGG TACTACGCGCTGTCCGCCATGCTCATCGCTGGCTGCATCTACAAGTACATCGAGTACCGCGGGGCCGAGAAGGAGTGGGGCGATGGCATC CGTGGCCTATCCCTGAACGCCGCCCGCTACGCCCTGCTGCGCGTGGAGCACGGTCCCCCCCACACCAAGAACTGGAGGCCCCAGGTGCTG GTGATGCTGAACCTGGACGCGGAGCAGGCCGTGAAGCACCCCCGCCTGCTGTCCTTCACGTCGCAGCTGAAGGCCGGCAAGGGCCTGACC ATCGTGGGCTCGGTGCTGGAGGGGACGTACCTGGACAAGCACATGGAGGCTCAGCGGGCCGAGGAGAACATACGGTCCCTAATGAGCACA GAGAAGACCAAGGGCTTCTGCCAGCTGGTGGTCTCGTCCAGCCTGCGGGATGGCATGTCCCACCTGATCCAGTCGGCCGGCCTGGGCGGC CTGAAGCACAACACGGTGCTCATGGCCTGGCCCGCATCCTGGAAGCAGGAGGACAACCCCTTCTCCTGGAAGAACTTTGTGGACACCGTC CGCGACACCACCGCCGCGCACCAGGCTCTGCTGGTGGCCAAGAACGTCGACTCGTTTCCGCAAAACCAGGAGCGCTTCGGCGGGGGCCAC ATCGACGTGTGGTGGATCGTGCACGACGGCGGCATGCTCATGCTGCTGCCCTTCCTGCTGCGCCAGCACAAGGTGTGGAGGAAGTGCCGG ATGCGTATCTTCACCGTGGCCCAGGTGGACGACAACAGCATCCAGATGAAGAAGGACCTGCAGATGTTCTTGTACCACTTGCGCATCAGC GCCGAGGTGGAGGTGGTGGAGATGGTTGAAAACGACATATCTGCTTTCACCTACGAGAGGACACTAATGATGGAGCAGAGGTCGCAGATG CTGAAGCAGATGCAGCTGTCCAAGAACGAGCAGGAGCGAGAGGCCCAGCTGATCCACGACAGGAACACCGCGTCCCACACCGCGGCGGCA GCCAGGACCCAAGCGCCGCCTACGCCAGACAAGGTGCAGATGACCTGGACCAGGGAGAAGCTGATCGCTGAGAAGTACAGGAGCAGAGAC ACCAGCCTATCTGGTTTCAAAGACCTCTTCAGCATGAAGCCGGACCAGTCCAACGTCAGGCGGATGCACACGGCTGTGAAGCTCAATGGC GTCGTCCTCAACAAGTCCCAGGATGCGCAGCTGGTCCTGCTCAACATGCCAGGTCCTCCCAAAAACCGGCAGGGAGACGAGAACTACATG GAGTTTCTTGAAGTCCTGACCGAGGGGCTGAACAGAGTCCTCCTGGTCAGGGGTGGCGGCCGGGAGGTGATCACCATCTACTCCTAATGC CCAACAGCATCACGGCACTCTGGGACAGGCACGGAGGACGGCGTGGGCAGCCTGGGCCTGGGCTTGGCCCAGGGAAACAGACGGCAGACA CACCTGTCCCCCAGTGATGCCGCCCAAGCTGCCCATGGGGCTTCCTACGGAAGTTTCTAGGCCCGTCACCTAGGGCTCTCCTGTTCAGCC TTAACAGGCTCAGCAAATCAGGGCGTGGCTGGACGATTTCCTTGCATCTGAGGGCAGACGCTGCTACCGGAGTGACCTGGACGTGGCCAG ATCTTCTCGCAGGTCACAAGAAGCCAGTGAGCCCTTGCCTTGGTTTCTGGAAGTTCTTTTCCTTGGCTGGATTTACCCAGTGGTTAGGTT GCATTTCTACCCCATCCAGAACATTCTTGGAAGAGCACCCGGAGCTGAAGCTGTCCCTGATGATGAAGGTGAAACGTCAGCCCTGGCCAT GGCTCCGCTCAGGGCCCCGGTCACCTCCGAGTCACTCTGTTCCTTGACTGTCTTTGTGTTTCTGTACCTCAAGGCACTGAAGCTGGAGGA CTCTGTCCATGCCCGTGTCACCCTCGTGTGGGAGCCTCTGGGCTCGGCAGGTCCACATTTCATGAGCTGAGGCGTGGGCCAGGGCCATCT GGAAAGGGAACTCGGCTTTTCCAGAACGTGGTGGATCATCTGTCGGGTGTGTGGTGAACACGTTCAGTTCATCAGGGCCTACGCTCCGGG AAGGGGCCCCCAGCTGTGGCTCTGCCATGCCGGGCTGTGTTTGCAGCTGTCCGAGTCTCCATCCACCTTTAGAAAACCAGCCACTTCTTT TCATAAGCACTGACAGGGCCCAGCCCACAGCCACAGGTGCGATCAGTGCCTCACGCAGGCAAATGCACTGAAACCCAGGGGCACACGCGC GCAGAGTGAACAGTGAGTTCCCCCGACAGCCCACGACAGCCAGGACTGCCCTCCCCACCCCACCCCACCCCAGGAGCACGGCACACAGTT CAGCCTCTGAGCTGGCTCACACGTGCCATCCCCACCCCGGTGCTCCAGGGAAGGAGGACACGGACCCGACGTGGGAGGTCCTCAGGCAGC AGTGGCGCCTGGTGTCAGGTCTGTCTGGCTGAGTCCCGGGCGTCCCCTGCCATGGCCTGTGCCTTGCATGGAGGCGGCGGTGGCACTGAA GAGATAGCTTTCAAGGGCCCAACACTTTGCACTTCGGCTGGCTGTGAGTTTCTGCTTTGTAGGTTGTGGTCACATTTGCAGGCTGCGGGC AGTGGCACCGACTTGGGCCTCCCTTTCTATGTGGCATATTTATTTATTTAAACACCCCAGGGAGTTACGTGGTAACAAGGTTGTCCATAA AGAGGTTGCTTCTATATACTAGAGGCCCCAGATGGCCAGGCCTTGGGCTACGTCTGGCTTGCATGGTCTCCCAAGGGAATCAGCCCCATC AACAAAGTTCAAATCGGGGCAGAGGCTGCACTTGTGCCCCCAGATGTTTCTGAGGAGCCAGACTAGGGCTGGCATTGCTGTAGAGTGACG GCTGCTGCCCAGAGCGTGTCCCAGACATCACAGCGGGGCTCAGCAGTTCCCACAGCCTCTGCCTGCCTTGGCTAAGCATGAGTTAAGCAG CAAAACGCTCCTCCATGTCTGGATGGGGCCGGCAGGTCCTGTGTCCCCTGCACCTGGAGGAGAGCAGGCTAGAGGCACAGCGGCCACATG GTGCTGGCTCTGAACGTTGGTTGGTGGCTGGAAAACAGCCCTGCTTCTGAGGGCCGCTCAGTTCTGCACACGAAACCACCTCCTGAGGGC TCAGCTCTGCCCCCGCCCTGGGCTGCAGCCTCTGCACGCAAGCACCAGGCATCCTTTGTGTTGTCAACTCCGTGTAACCAGTAACTACAG >In-frame_TAF1A_ENST00000543857_chr1_222757470_-_SLC12A7_ENST00000264930_chr5_1085588_-_5053nt ACTTCCGGGGTCGAGGCGAGGCCAACGATACGCCTGCTGCAGCAGGAGGAGTTACGAGCCGGGCCGCGCGCTGCCTAAATACCTAAACCA GGTTTAGCGCCTGCTCATATAAAGCTCTCCTAACTCGTCTTCCGGTGGGAATTTCTTCACGTGGGCCGGAGTCGGAGACTGAGTTTAGCT TTACTGAGGAGCTCTAAATTTAGGCGGGTATGAGTGATTTCAGTGAAGAATTAAAAGGGCCTGTGACAGATGATGAAGAAGTGGAAACAT CTGTGCTCAGTGGTGCAGGAATGCATTTTCCTTGGCTTCAAACATACGTAGAAACTGTGGCCATTGGAGGGAAAAGGAGGAAGGATTTTG CTCAGACAACAAGTGCTTGTTTAAGTTTTATCCAAGAAGCTCTGCTGAAGCACCAATGGCAGCAAGCTGCAGAATACATGTACAGTTATT TTCAGACCTTGGAAGATTCAGATAGCTACAAAAGGCAGGCTGCACCTGAGACGTACATCTCCCCGGGTGCGGCCATCTTCCAGGCGGAGG CTGCAGGTGGCGAGGCGGCCGCCATGCTGCACAACATGCGTGTGTACGGCACGTGCACGCTCGTGCTCATGGCCCTGGTGGTCTTCGTGG GCGTCAAGTATGTCAACAAGCTGGCGCTGGTCTTCCTGGCCTGCGTCGTGCTGTCCATCCTGGCCATCTATGCCGGCGTCATCAAGTCTG CCTTCGACCCCCCGGACATCCCGGTCTGCCTCCTGGGGAACCGCACGCTGTCACGGCGCAGCTTCGATGCCTGCGTCAAGGCCTACGGCA TCCACAACAACTCAGCCACCTCCGCGCTCTGGGGCCTCTTCTGCAACGGCTCCCAGCCCAGCGCCGCCTGTGACGAGTACTTCATCCAGA ACAACGTCACCGAAATCCAGGGCATCCCGGGCGCGGCCAGTGGTGTCTTCCTGGAGAACCTGTGGAGTACGTACGCGCACGCGGGGGCGT TTGTGGAGAAGAAAGGTGTGCCCTCGGTGCCCGTGGCAGAGGAGAGCCGTGCCAGCGCACTGCCCTACGTGCTCACCGACATCGCGGCCT CCTTCACCCTGCTGGTTGGCATCTACTTCCCTTCCGTGACCGGTATCATGGCGGGTTCAAACCGGTCCGGGGACCTCAAGGATGCACAGA AGTCCATCCCCACGGGGACCATCCTGGCCATAGTGACGACGTCTTTCATCTATCTCTCCTGCATTGTGCTGTTTGGGGCCTGCATTGAAG GCGTGGTCTTACGAGATAAGTTCGGGGAGGCCCTGCAGGGGAACCTGGTCATCGGCATGCTGGCCTGGCCCTCCCCCTGGGTCATCGTCA TCGGCTCCTTCTTCTCCACCTGCGGTGCCGGCCTGCAGAGCCTCACGGGGGCACCGCGCCTACTGCAGGCCATTGCCCGTGACGGCATCG TCCCCTTCCTGCAGGTGTTTGGCCACGGGAAGGCCAACGGGGAGCCCACGTGGGCGCTGCTGCTGACAGTCCTCATCTGCGAGACTGGCA TCCTCATCGCCTCTCTGGACAGCGTGGCCCCGATCCTCTCCATGTTCTTCCTCATGTGCTACCTGTTCGTGAACCTGGCCTGCGCCGTGC AGACCCTGCTACGTACCCCCAACTGGCGTCCACGCTTCAAGTTCTACCACTGGACCCTGTCCTTTCTGGGTATGAGCCTGTGCCTGGCGC TGATGTTCATCTGCTCCTGGTACTACGCGCTGTCCGCCATGCTCATCGCTGGCTGCATCTACAAGTACATCGAGTACCGCGGGGCCGAGA AGGAGTGGGGCGATGGCATCCGTGGCCTATCCCTGAACGCCGCCCGCTACGCCCTGCTGCGCGTGGAGCACGGTCCCCCCCACACCAAGA ACTGGAGGCCCCAGGTGCTGGTGATGCTGAACCTGGACGCGGAGCAGGCCGTGAAGCACCCCCGCCTGCTGTCCTTCACGTCGCAGCTGA AGGCCGGCAAGGGCCTGACCATCGTGGGCTCGGTGCTGGAGGGGACGTACCTGGACAAGCACATGGAGGCTCAGCGGGCCGAGGAGAACA TACGGTCCCTAATGAGCACAGAGAAGACCAAGGGCTTCTGCCAGCTGGTGGTCTCGTCCAGCCTGCGGGATGGCATGTCCCACCTGATCC AGTCGGCCGGCCTGGGCGGCCTGAAGCACAACACGGTGCTCATGGCCTGGCCCGCATCCTGGAAGCAGGAGGACAACCCCTTCTCCTGGA AGAACTTTGTGGACACCGTCCGCGACACCACCGCCGCGCACCAGGCTCTGCTGGTGGCCAAGAACGTCGACTCGTTTCCGCAAAACCAGG AGCGCTTCGGCGGGGGCCACATCGACGTGTGGTGGATCGTGCACGACGGCGGCATGCTCATGCTGCTGCCCTTCCTGCTGCGCCAGCACA AGGTGTGGAGGAAGTGCCGGATGCGTATCTTCACCGTGGCCCAGGTGGACGACAACAGCATCCAGATGAAGAAGGACCTGCAGATGTTCT TGTACCACTTGCGCATCAGCGCCGAGGTGGAGGTGGTGGAGATGGTTGAAAACGACATATCTGCTTTCACCTACGAGAGGACACTAATGA TGGAGCAGAGGTCGCAGATGCTGAAGCAGATGCAGCTGTCCAAGAACGAGCAGGAGCGAGAGGCCCAGCTGATCCACGACAGGAACACCG CGTCCCACACCGCGGCGGCAGCCAGGACCCAAGCGCCGCCTACGCCAGACAAGGTGCAGATGACCTGGACCAGGGAGAAGCTGATCGCTG AGAAGTACAGGAGCAGAGACACCAGCCTATCTGGTTTCAAAGACCTCTTCAGCATGAAGCCGGACCAGTCCAACGTCAGGCGGATGCACA CGGCTGTGAAGCTCAATGGCGTCGTCCTCAACAAGTCCCAGGATGCGCAGCTGGTCCTGCTCAACATGCCAGGTCCTCCCAAAAACCGGC AGGGAGACGAGAACTACATGGAGTTTCTTGAAGTCCTGACCGAGGGGCTGAACAGAGTCCTCCTGGTCAGGGGTGGCGGCCGGGAGGTGA TCACCATCTACTCCTAATGCCCAACAGCATCACGGCACTCTGGGACAGGCACGGAGGACGGCGTGGGCAGCCTGGGCCTGGGCTTGGCCC AGGGAAACAGACGGCAGACACACCTGTCCCCCAGTGATGCCGCCCAAGCTGCCCATGGGGCTTCCTACGGAAGTTTCTAGGCCCGTCACC TAGGGCTCTCCTGTTCAGCCTTAACAGGCTCAGCAAATCAGGGCGTGGCTGGACGATTTCCTTGCATCTGAGGGCAGACGCTGCTACCGG AGTGACCTGGACGTGGCCAGATCTTCTCGCAGGTCACAAGAAGCCAGTGAGCCCTTGCCTTGGTTTCTGGAAGTTCTTTTCCTTGGCTGG ATTTACCCAGTGGTTAGGTTGCATTTCTACCCCATCCAGAACATTCTTGGAAGAGCACCCGGAGCTGAAGCTGTCCCTGATGATGAAGGT GAAACGTCAGCCCTGGCCATGGCTCCGCTCAGGGCCCCGGTCACCTCCGAGTCACTCTGTTCCTTGACTGTCTTTGTGTTTCTGTACCTC AAGGCACTGAAGCTGGAGGACTCTGTCCATGCCCGTGTCACCCTCGTGTGGGAGCCTCTGGGCTCGGCAGGTCCACATTTCATGAGCTGA GGCGTGGGCCAGGGCCATCTGGAAAGGGAACTCGGCTTTTCCAGAACGTGGTGGATCATCTGTCGGGTGTGTGGTGAACACGTTCAGTTC ATCAGGGCCTACGCTCCGGGAAGGGGCCCCCAGCTGTGGCTCTGCCATGCCGGGCTGTGTTTGCAGCTGTCCGAGTCTCCATCCACCTTT AGAAAACCAGCCACTTCTTTTCATAAGCACTGACAGGGCCCAGCCCACAGCCACAGGTGCGATCAGTGCCTCACGCAGGCAAATGCACTG AAACCCAGGGGCACACGCGCGCAGAGTGAACAGTGAGTTCCCCCGACAGCCCACGACAGCCAGGACTGCCCTCCCCACCCCACCCCACCC CAGGAGCACGGCACACAGTTCAGCCTCTGAGCTGGCTCACACGTGCCATCCCCACCCCGGTGCTCCAGGGAAGGAGGACACGGACCCGAC GTGGGAGGTCCTCAGGCAGCAGTGGCGCCTGGTGTCAGGTCTGTCTGGCTGAGTCCCGGGCGTCCCCTGCCATGGCCTGTGCCTTGCATG GAGGCGGCGGTGGCACTGAAGAGATAGCTTTCAAGGGCCCAACACTTTGCACTTCGGCTGGCTGTGAGTTTCTGCTTTGTAGGTTGTGGT CACATTTGCAGGCTGCGGGCAGTGGCACCGACTTGGGCCTCCCTTTCTATGTGGCATATTTATTTATTTAAACACCCCAGGGAGTTACGT GGTAACAAGGTTGTCCATAAAGAGGTTGCTTCTATATACTAGAGGCCCCAGATGGCCAGGCCTTGGGCTACGTCTGGCTTGCATGGTCTC CCAAGGGAATCAGCCCCATCAACAAAGTTCAAATCGGGGCAGAGGCTGCACTTGTGCCCCCAGATGTTTCTGAGGAGCCAGACTAGGGCT GGCATTGCTGTAGAGTGACGGCTGCTGCCCAGAGCGTGTCCCAGACATCACAGCGGGGCTCAGCAGTTCCCACAGCCTCTGCCTGCCTTG GCTAAGCATGAGTTAAGCAGCAAAACGCTCCTCCATGTCTGGATGGGGCCGGCAGGTCCTGTGTCCCCTGCACCTGGAGGAGAGCAGGCT AGAGGCACAGCGGCCACATGGTGCTGGCTCTGAACGTTGGTTGGTGGCTGGAAAACAGCCCTGCTTCTGAGGGCCGCTCAGTTCTGCACA CGAAACCACCTCCTGAGGGCTCAGCTCTGCCCCCGCCCTGGGCTGCAGCCTCTGCACGCAAGCACCAGGCATCCTTTGTGTTGTCAACTC CGTGTAACCAGTAACTACAGCCATTTACAATTGACTCCGTTTCCTTTTGTAGGTTTCCCTGTCTGTCTGTGTTAGTAGAAAAATAAAATC |
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FusionGenePPI for TAF1A_SLC12A7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAF1A | TBP, TAF1B, TAF1C, RRN3, TP53, UBTF, SET, ANP32A, HIST4H4, HIST3H3, TAF1D, ESR1, HIST2H2AC, HIST1H4A, HIST1H3A, HIST2H2BE, TAF12, JMJD6, C11orf57, RPL14, EAF1, NIFK, VWA9, NAF1, TRIM44, RBM34, ZNF512, RPL37A, MECP2, RPL30 | SLC12A7 | POPDC2, LGALS3, LGALS8, LGALS9, PTH1R, LGALS9C, TMEM17, CTDSPL, NRN1, PTGIR, GPR21, ZNRF4, SLC17A2, C5AR2, NMUR2, FSHR, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1A_SLC12A7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SLC12A7 | Q9Y666 | DB00761 | Potassium Chloride | Solute carrier family 12 member 7 | small molecule | approved|withdrawn |
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RelatedDiseases for TAF1A_SLC12A7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC12A7 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
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