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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3708

FusionGeneSummary for B3GAT2_SMAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: B3GAT2_SMAP1
Fusion gene ID: 3708
HgeneTgene
Gene symbol

B3GAT2

SMAP1

Gene ID

135152

60682

Gene namebeta-1,3-glucuronyltransferase 2small ArfGAP 1
SynonymsGLCATSSMAP-1
Cytomap

6q13

6q13

Type of geneprotein-codingprotein-coding
Descriptiongalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2UDP-glucuronosyltransferase SUDP-glucuronyltransferase SglcAT-Dglucuronosyltransferase Suridine diphosphate glucuronic acid:acceptor glucuronosyltransferasestromal membrane-associated protein 1stromal membrane-associated GTPase-activating protein 1
Modification date2018052320180523
UniProtAcc

Q9NPZ5

Q8IYB5

Ensembl transtripts involved in fusion geneENST00000230053, ENST00000316999, 
ENST00000370452, ENST00000370455, 
ENST00000422334, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B3GAT2 [Title/Abstract] AND SMAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DR002957B3GAT2chr6

71666248

+SMAP1chr6

71665584

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000230053ENST00000316999B3GAT2chr6

71666248

+SMAP1chr6

71665584

-
intron-intronENST00000230053ENST00000370452B3GAT2chr6

71666248

+SMAP1chr6

71665584

-
intron-intronENST00000230053ENST00000370455B3GAT2chr6

71666248

+SMAP1chr6

71665584

-
intron-intronENST00000230053ENST00000422334B3GAT2chr6

71666248

+SMAP1chr6

71665584

-

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FusionProtFeatures for B3GAT2_SMAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B3GAT2

Q9NPZ5

SMAP1

Q8IYB5

Involved in the biosynthesis of L2/HNK-1 carbohydrateepitope on both glycolipids and glycoproteins.{ECO:0000250|UniProtKB:O35789}. GTPase activating protein that acts on ARF6. Plays arole in clathrin-dependent endocytosis. May play a role inerythropoiesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for B3GAT2_SMAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for B3GAT2_SMAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B3GAT2_SMAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for B3GAT2_SMAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneB3GAT2C0036341Schizophrenia1PSYGENET