FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37079

FusionGeneSummary for TAF15_PDK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF15_PDK3
Fusion gene ID: 37079
HgeneTgene
Gene symbol

TAF15

PDK3

Gene ID

8148

5165

Gene nameTATA-box binding protein associated factor 15pyruvate dehydrogenase kinase 3
SynonymsNpl3|RBP56|TAF2N|TAFII68CMTX6|GS1-358P8.4
Cytomap

17q12

Xp22.11

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-binpyruvate dehydrogenase kinase, isozyme 3[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrialpyruvate dehydrogenase kinase, isoenzyme 3pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Modification date2018052320180519
UniProtAcc

Q92804

Q15120

Ensembl transtripts involved in fusion geneENST00000588240, ENST00000592237, 
ENST00000311979, 
ENST00000379162, 
ENST00000441463, ENST00000493226, 
Fusion gene scores* DoF score9 X 7 X 4=2523 X 4 X 3=36
# samples 154
** MAII scorelog2(15/252*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TAF15 [Title/Abstract] AND PDK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDK3

GO:0018105

peptidyl-serine phosphorylation

11486000


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-D7-6527-01ATAF15chr17

34136580

+PDK3chrX

24549774

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000588240ENST00000379162TAF15chr17

34136580

+PDK3chrX

24549774

+
Frame-shitENST00000588240ENST00000441463TAF15chr17

34136580

+PDK3chrX

24549774

+
5CDS-intronENST00000588240ENST00000493226TAF15chr17

34136580

+PDK3chrX

24549774

+
5UTR-3CDSENST00000592237ENST00000379162TAF15chr17

34136580

+PDK3chrX

24549774

+
5UTR-3CDSENST00000592237ENST00000441463TAF15chr17

34136580

+PDK3chrX

24549774

+
5UTR-intronENST00000592237ENST00000493226TAF15chr17

34136580

+PDK3chrX

24549774

+
Frame-shitENST00000311979ENST00000379162TAF15chr17

34136580

+PDK3chrX

24549774

+
Frame-shitENST00000311979ENST00000441463TAF15chr17

34136580

+PDK3chrX

24549774

+
5CDS-intronENST00000311979ENST00000493226TAF15chr17

34136580

+PDK3chrX

24549774

+

Top

FusionProtFeatures for TAF15_PDK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAF15

Q92804

PDK3

Q15120

RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269|PubMed:19124016}. Inhibits pyruvate dehydrogenase activity byphosphorylation of the E1 subunit PDHA1, and thereby regulatesglucose metabolism and aerobic respiration. Can also phosphorylatePDHA2. Decreases glucose utilization and increases fat metabolismin response to prolonged fasting, and as adaptation to a high-fatdiet. Plays a role in glucose homeostasis and in maintainingnormal blood glucose levels in function of nutrient levels andunder starvation. Plays a role in the generation of reactiveoxygen species. {ECO:0000269|PubMed:10748134,ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126,ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942,ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TAF15_PDK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TAF15_PDK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAF15SAFB, PRMT1, TAF7, TAF5, TAF13, TAF11, POLR2C, POLR2G, POLR2E, SF1, KAT2B, POLR2A, HIST2H2AC, HIST1H3A, HIST2H4A, CACNA1A, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDB1, TPR, SAP30BP, RNF168, SCARB2, TPM2, TMED9, MED26, PRMT8, FUS, RPA3, RPA2, RPA1, HIST3H3, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, RPS6KB2, ACAA2, SFN, HNRNPA1, PPP1CB, MATR3, MED12, MCM2, NF2, DNPEP, KLHL8, TRIM25, BRCA1PDK3DLAT, EGFR, ICT1, APP, PDHB, DLD, PDK1, CCT6A, HLTF, TCP1, CCT3, UTRN, VCP, CCT7, CCT4, CCT2, CCT8, ECD, CCT5, ACAP2, UBR7, CECR5, PDHA2, PDK2, FOXD4, PDK4, PDHX, SYT12, PDHA1, STAT5A, DNLZ, NDUFS7, ACAD9, HSPD1, EIF1AX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TAF15_PDK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TAF15_PDK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAF15C0029463Osteosarcoma1CTD_human
HgeneTAF15C0038356Stomach Neoplasms1CTD_human
TgenePDK3C3806702CHARCOT-MARIE-TOOTH DISEASE, X-LINKED DOMINANT, 61ORPHANET;UNIPROT