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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37077

FusionGeneSummary for TAF15_NR4A3

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF15_NR4A3
Fusion gene ID: 37077
HgeneTgene
Gene symbol

TAF15

NR4A3

Gene ID

8148

8013

Gene nameTATA-box binding protein associated factor 15nuclear receptor subfamily 4 group A member 3
SynonymsNpl3|RBP56|TAF2N|TAFII68CHN|CSMF|MINOR|NOR1|TEC
Cytomap

17q12

9q31.1

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-binnuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma
Modification date2018052320180527
UniProtAcc

Q92804

Q92570

Ensembl transtripts involved in fusion geneENST00000588240, ENST00000592237, 
ENST00000311979, 
ENST00000338488, 
ENST00000395097, ENST00000330847, 
Fusion gene scores* DoF score9 X 7 X 4=2526 X 6 X 4=144
# samples 1510
** MAII scorelog2(15/252*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/144*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAF15 [Title/Abstract] AND NR4A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR4A3

GO:0010828

positive regulation of glucose transmembrane transport

24022864

TgeneNR4A3

GO:0045944

positive regulation of transcription by RNA polymerase II

20558821

TgeneNR4A3

GO:0048008

platelet-derived growth factor receptor signaling pathway

23554459

TgeneNR4A3

GO:0048660

regulation of smooth muscle cell proliferation

25852083


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF162670TAF15chr17

34149837

+NR4A3chr9

102590321

+
ChiTaRS3.1AJ243810TAF15chr17

34149837

+NR4A3chr9

102590321

+
ChiTaRS3.1AJ245932TAF15chr17

34149837

+NR4A3chr9

102590321

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000588240ENST00000338488TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000588240ENST00000395097TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000588240ENST00000330847TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000592237ENST00000338488TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000592237ENST00000395097TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000592237ENST00000330847TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000311979ENST00000338488TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000311979ENST00000395097TAF15chr17

34149837

+NR4A3chr9

102590321

+
5CDS-5UTRENST00000311979ENST00000330847TAF15chr17

34149837

+NR4A3chr9

102590321

+

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FusionProtFeatures for TAF15_NR4A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAF15

Q92804

NR4A3

Q92570

RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269|PubMed:19124016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAF15_NR4A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAF15_NR4A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAF15SAFB, PRMT1, TAF7, TAF5, TAF13, TAF11, POLR2C, POLR2G, POLR2E, SF1, KAT2B, POLR2A, HIST2H2AC, HIST1H3A, HIST2H4A, CACNA1A, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDB1, TPR, SAP30BP, RNF168, SCARB2, TPM2, TMED9, MED26, PRMT8, FUS, RPA3, RPA2, RPA1, HIST3H3, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, RPS6KB2, ACAA2, SFN, HNRNPA1, PPP1CB, MATR3, MED12, MCM2, NF2, DNPEP, KLHL8, TRIM25, BRCA1NR4A3SIX3, KDM5B, TRIM28, COPS5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAF15_NR4A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNR4A3Q92570DB01254DasatinibNuclear receptor subfamily 4 group A member 3small moleculeapproved|investigational

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RelatedDiseases for TAF15_NR4A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAF15C0029463Osteosarcoma1CTD_human
HgeneTAF15C0038356Stomach Neoplasms1CTD_human
TgeneNR4A3C0003873Rheumatoid Arthritis1CTD_human
TgeneNR4A3C0020443Hypercholesterolemia1CTD_human
TgeneNR4A3C0021655Insulin Resistance1CTD_human
TgeneNR4A3C3495559Juvenile arthritis1CTD_human