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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37074

FusionGeneSummary for TAF15_DCAF8

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF15_DCAF8
Fusion gene ID: 37074
HgeneTgene
Gene symbol

TAF15

DCAF8

Gene ID

8148

50717

Gene nameTATA-box binding protein associated factor 15DDB1 and CUL4 associated factor 8
SynonymsNpl3|RBP56|TAF2N|TAFII68GAN2|H326|WDR42A
Cytomap

17q12

1q23.2

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-binDDB1- and CUL4-associated factor 8WD repeat domain 42AWD repeat-containing protein 42A
Modification date2018052320180519
UniProtAcc

Q92804

Q5TAQ9

Ensembl transtripts involved in fusion geneENST00000588240, ENST00000592237, 
ENST00000311979, 
ENST00000368073, 
ENST00000326837, ENST00000368074, 
ENST00000608310, ENST00000556710, 
ENST00000610139, ENST00000475733, 
Fusion gene scores* DoF score9 X 7 X 4=2529 X 12 X 4=432
# samples 1514
** MAII scorelog2(15/252*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/432*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAF15 [Title/Abstract] AND DCAF8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI343022TAF15chr17

34171227

+DCAF8chr1

160247476

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000588240ENST00000368073TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000588240ENST00000326837TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000588240ENST00000368074TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000588240ENST00000608310TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000588240ENST00000556710TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000588240ENST00000610139TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000588240ENST00000475733TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000368073TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000326837TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000368074TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000608310TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000556710TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000610139TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000592237ENST00000475733TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000368073TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000326837TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000368074TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000608310TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000556710TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000610139TAF15chr17

34171227

+DCAF8chr1

160247476

+
intron-intronENST00000311979ENST00000475733TAF15chr17

34171227

+DCAF8chr1

160247476

+

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FusionProtFeatures for TAF15_DCAF8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAF15

Q92804

DCAF8

Q5TAQ9

RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269|PubMed:19124016}. May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAF15_DCAF8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAF15_DCAF8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAF15_DCAF8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAF15_DCAF8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAF15C0029463Osteosarcoma1CTD_human
HgeneTAF15C0038356Stomach Neoplasms1CTD_human
TgeneDCAF8C4013360GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT1ORPHANET;UNIPROT