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Fusion gene ID: 37064 |
FusionGeneSummary for TADA2A_STARD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TADA2A_STARD3 | Fusion gene ID: 37064 | Hgene | Tgene | Gene symbol | TADA2A | STARD3 | Gene ID | 6871 | 10948 |
| Gene name | transcriptional adaptor 2A | StAR related lipid transfer domain containing 3 | |
| Synonyms | ADA2|ADA2A|KL04P|TADA2L|hADA2 | CAB1|MLN64|es64 | |
| Cytomap | 17q12 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcriptional adapter 2-alphaADA2-like proteintranscriptional adaptor 2 alpha | stAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O75478 | Q14849 | |
| Ensembl transtripts involved in fusion gene | ENST00000394395, ENST00000586023, ENST00000225396, ENST00000417170, ENST00000591992, | ENST00000336308, ENST00000578232, ENST00000544210, ENST00000394250, ENST00000580611, | |
| Fusion gene scores | * DoF score | 10 X 9 X 6=540 | 10 X 3 X 7=210 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TADA2A [Title/Abstract] AND STARD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TADA2A | GO:0043966 | histone H3 acetylation | 9674425 |
| Tgene | STARD3 | GO:0030301 | cholesterol transport | 28377464 |
| Tgene | STARD3 | GO:0099044 | vesicle tethering to endoplasmic reticulum | 24105263|28377464 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XJ-01A | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000394395 | ENST00000336308 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-intron | ENST00000394395 | ENST00000578232 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000394395 | ENST00000544210 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000394395 | ENST00000394250 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000394395 | ENST00000580611 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000586023 | ENST00000336308 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-intron | ENST00000586023 | ENST00000578232 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000586023 | ENST00000544210 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000586023 | ENST00000394250 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000586023 | ENST00000580611 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000225396 | ENST00000336308 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-intron | ENST00000225396 | ENST00000578232 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000225396 | ENST00000544210 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000225396 | ENST00000394250 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000225396 | ENST00000580611 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000417170 | ENST00000336308 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-intron | ENST00000417170 | ENST00000578232 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000417170 | ENST00000544210 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000417170 | ENST00000394250 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| 5CDS-5UTR | ENST00000417170 | ENST00000580611 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| intron-5UTR | ENST00000591992 | ENST00000336308 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| intron-intron | ENST00000591992 | ENST00000578232 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| intron-5UTR | ENST00000591992 | ENST00000544210 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| intron-5UTR | ENST00000591992 | ENST00000394250 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
| intron-5UTR | ENST00000591992 | ENST00000580611 | TADA2A | chr17 | 35771477 | + | STARD3 | chr17 | 37809734 | + |
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FusionProtFeatures for TADA2A_STARD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TADA2A | STARD3 |
| Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4. Required for thefunction of some acidic activation domains, which activatetranscription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker regionbetween neighboring nucleosomes. Plays a role in chromatinremodeling. May promote TP53/p53 'Lys-321' acetylation, leading toreduced TP53 stability and transcriptional activity(PubMed:22644376). May also promote XRCC6 acetylation thusfacilitating cell apoptosis in response to DNA damage(PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6,ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}. | Sterol-binding protein that mediates cholesteroltransport from the endoplasmic reticulum to endosomes(PubMed:11053434, PubMed:15930133, PubMed:22514632,PubMed:28377464). Creates contact site between the endoplasmicreticulum and late endosomes: localizes to late endosome membranesand contacts the endoplasmic reticulum via interaction with VAPAand VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipidtransfer protein that redirects sterol to the endosome at theexpense of the cell membrane and favors membrane formation insideendosomes (PubMed:28377464). May also mediate cholesteroltransport between other membranes, such as mitochondria membraneor cell membrane (PubMed:12070139, PubMed:19965586). However, suchresults need additional experimental evidences; probably mainlymediates cholesterol transport from the endoplasmic reticulum toendosomes (PubMed:28377464). Does not activate transcriptionalcholesterol sensing (PubMed:28377464). Able to bind other lipids,such as lutein, a xanthophyll carotenoids that form the macularpigment of the retina (PubMed:21322544).{ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139,ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586,ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632,ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TADA2A_STARD3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TADA2A_STARD3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TADA2A | EXOC8, FAM107A, HGS, TADA3, MYC, NR3C1, KAT2A, ATXN7, TP53, CTNNB1, KAT2B, MED1, MED26, CCDC101, ERCC4, CDK8, SRSF1, DDX3X, LUC7L, RNF41, DHX16, DDB1, MED29, TRIM28, SNRPA, SSB, NCBP1, PRPF6, CDC40, SRSF3, WDTC1, RBM39, MED30, MED28, PSPC1, TRA2B, TRA2A, RALY, NONO, PRRC2B, PLRG1, HELT, SRSF4, XAB2, MED8, PUF60, MED25, DHX15, RNPS1, SRSF5, EIF3H, SRRM1, LRCH4, MYEF2, RBM14, EIF3I, MED20, EIF3C, EIF3M, SIN3A, EIF3B, EIF3L, PRPF19, HNRNPC, ILF3, CDC5L, AKAP8, MED18, SNW1, HDAC1, MARK3, PABPC1P1, C11orf30, KRT8, POLR2A, SRRM2, MED16, ILF2, HSPA5, MED14, MED31, LUC7L3, DDX5, MED4, SFPQ, MED15, MED17, DDX17, POLR2B, WDR5, HNRNPF, ACTC1, DOCK6, LUZP1, MED27, POLR2C, HNRNPM, MARK2, MED22, MED23, ZZZ3, MED6, MED12, MED13, YEATS2, DR1, MBIP, SUPT3H, TCF3, PAXIP1, HSP90AA1, HNF4A, LYN, MCPH1, USP22, ARNT2, PRKAB2, KPNA2, MAGOH, MFAP1, EIF4E2, MTX2, FARS2, SF3A3, ZFYVE26, PPP1R16B, PRPF31, CCHCR1, C1orf109, CDCA7L, GPSM3, TTC23, FBF1, KLC4, LOC149950, TEKT4, ZNF564, TTC9C, KLHL38, FAM127C, PSME3, CARD8, PSMC3, IKZF5, CDH19 | STARD3 | GOPC, SPACA1, SDF4, ERGIC3, HEPACAM2, VAPB, CREB3, C19orf26, MME, P2RX2, SLC15A1, CHRM3, MANSC1, PMEL, CLEC2D, TSPYL6, TRIM25, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TADA2A_STARD3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TADA2A_STARD3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | STARD3 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | STARD3 | C3496069 | cocaine use | 1 | PSYGENET |
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