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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37061

FusionGeneSummary for TADA2A_NT5C3B

check button Fusion gene summary
Fusion gene informationFusion gene name: TADA2A_NT5C3B
Fusion gene ID: 37061
HgeneTgene
Gene symbol

TADA2A

NT5C3B

Gene ID

6871

115024

Gene nametranscriptional adaptor 2A5'-nucleotidase, cytosolic IIIB
SynonymsADA2|ADA2A|KL04P|TADA2L|hADA2NT5C3L|cN-IIIB
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional adapter 2-alphaADA2-like proteintranscriptional adaptor 2 alpha7-methylguanosine phosphate-specific 5'-nucleotidase5'-nucleotidase, cytosolic III-like7-methylguanosine nucleotidaseN(7)-methylguanylate 5'-phosphatasecN-III-like proteincytosolic 5'-nucleotidase 3Bcytosolic 5'-nucleotidase III-like protein
Modification date2018052320180523
UniProtAcc

O75478

Q969T7

Ensembl transtripts involved in fusion geneENST00000394395, ENST00000586023, 
ENST00000225396, ENST00000417170, 
ENST00000591992, 
ENST00000269534, 
ENST00000521789, ENST00000435506, 
Fusion gene scores* DoF score10 X 9 X 6=5404 X 4 X 3=48
# samples 104
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TADA2A [Title/Abstract] AND NT5C3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTADA2A

GO:0043966

histone H3 acetylation

9674425


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8483-01ATADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394395ENST00000269534TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
Frame-shiftENST00000394395ENST00000521789TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
Frame-shiftENST00000394395ENST00000435506TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
intron-3CDSENST00000586023ENST00000269534TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
intron-3CDSENST00000586023ENST00000521789TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
intron-3CDSENST00000586023ENST00000435506TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
Frame-shiftENST00000225396ENST00000269534TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
Frame-shiftENST00000225396ENST00000521789TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
Frame-shiftENST00000225396ENST00000435506TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
intron-3CDSENST00000417170ENST00000269534TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
intron-3CDSENST00000417170ENST00000521789TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
intron-3CDSENST00000417170ENST00000435506TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
3UTR-3CDSENST00000591992ENST00000269534TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
3UTR-3CDSENST00000591992ENST00000521789TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-
3UTR-3CDSENST00000591992ENST00000435506TADA2Achr17

35830636

+NT5C3Bchr17

39988729

-

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FusionProtFeatures for TADA2A_NT5C3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TADA2A

O75478

NT5C3B

Q969T7

Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4. Required for thefunction of some acidic activation domains, which activatetranscription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker regionbetween neighboring nucleosomes. Plays a role in chromatinremodeling. May promote TP53/p53 'Lys-321' acetylation, leading toreduced TP53 stability and transcriptional activity(PubMed:22644376). May also promote XRCC6 acetylation thusfacilitating cell apoptosis in response to DNA damage(PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6,ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}. Specifically hydrolyzes 7-methylguanosine monophosphate(m(7)GMP) to 7-methylguanosine and inorganic phosphate(PubMed:23223233, PubMed:24603684). The specific activity form(7)GMP may protect cells against undesired salvage of m(7)GMP andits incorporation into nucleic acids (PubMed:23223233). Also hasweak activity for CMP (PubMed:23223233, PubMed:24603684). UMP andpurine nucleotides are poor substrates (PubMed:23223233).{ECO:0000269|PubMed:23223233, ECO:0000269|PubMed:24603684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TADA2A_NT5C3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TADA2A_NT5C3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TADA2AEXOC8, FAM107A, HGS, TADA3, MYC, NR3C1, KAT2A, ATXN7, TP53, CTNNB1, KAT2B, MED1, MED26, CCDC101, ERCC4, CDK8, SRSF1, DDX3X, LUC7L, RNF41, DHX16, DDB1, MED29, TRIM28, SNRPA, SSB, NCBP1, PRPF6, CDC40, SRSF3, WDTC1, RBM39, MED30, MED28, PSPC1, TRA2B, TRA2A, RALY, NONO, PRRC2B, PLRG1, HELT, SRSF4, XAB2, MED8, PUF60, MED25, DHX15, RNPS1, SRSF5, EIF3H, SRRM1, LRCH4, MYEF2, RBM14, EIF3I, MED20, EIF3C, EIF3M, SIN3A, EIF3B, EIF3L, PRPF19, HNRNPC, ILF3, CDC5L, AKAP8, MED18, SNW1, HDAC1, MARK3, PABPC1P1, C11orf30, KRT8, POLR2A, SRRM2, MED16, ILF2, HSPA5, MED14, MED31, LUC7L3, DDX5, MED4, SFPQ, MED15, MED17, DDX17, POLR2B, WDR5, HNRNPF, ACTC1, DOCK6, LUZP1, MED27, POLR2C, HNRNPM, MARK2, MED22, MED23, ZZZ3, MED6, MED12, MED13, YEATS2, DR1, MBIP, SUPT3H, TCF3, PAXIP1, HSP90AA1, HNF4A, LYN, MCPH1, USP22, ARNT2, PRKAB2, KPNA2, MAGOH, MFAP1, EIF4E2, MTX2, FARS2, SF3A3, ZFYVE26, PPP1R16B, PRPF31, CCHCR1, C1orf109, CDCA7L, GPSM3, TTC23, FBF1, KLC4, LOC149950, TEKT4, ZNF564, TTC9C, KLHL38, FAM127C, PSME3, CARD8, PSMC3, IKZF5, CDH19NT5C3BMLH1, SHMT2, MOV10, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TADA2A_NT5C3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TADA2A_NT5C3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource