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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37057

FusionGeneSummary for TADA2A_MED24

check button Fusion gene summary
Fusion gene informationFusion gene name: TADA2A_MED24
Fusion gene ID: 37057
HgeneTgene
Gene symbol

TADA2A

MED24

Gene ID

6871

9862

Gene nametranscriptional adaptor 2Amediator complex subunit 24
SynonymsADA2|ADA2A|KL04P|TADA2L|hADA2ARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100
Cytomap

17q12

17q21.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional adapter 2-alphaADA2-like proteintranscriptional adaptor 2 alphamediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10
Modification date2018052320180523
UniProtAcc

O75478

O75448

Ensembl transtripts involved in fusion geneENST00000394395, ENST00000586023, 
ENST00000225396, ENST00000417170, 
ENST00000591992, 		ENST00000394126, 
ENST00000356271, ENST00000394128, 
ENST00000394127, ENST00000501516, 
ENST00000479829, 
Fusion gene scores* DoF score10 X 9 X 6=54016 X 12 X 6=1152
# samples 1017
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1152*10)=-2.76053406530461
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TADA2A [Title/Abstract] AND MED24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTADA2A

GO:0043966

histone H3 acetylation

9674425

TgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

TgeneMED24

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

TgeneMED24

GO:0030521

androgen receptor signaling pathway

12218053

TgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0TQ-01ATADA2Achr17

35818689

+MED24chr17

38192407

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394395ENST00000394126TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000394395ENST00000356271TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000394395ENST00000394128TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000394395ENST00000394127TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000394395ENST00000501516TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-5UTRENST00000394395ENST00000479829TADA2Achr17

35818689

+MED24chr17

38192407

-
Frame-shiftENST00000586023ENST00000394126TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000586023ENST00000356271TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000586023ENST00000394128TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000586023ENST00000394127TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000586023ENST00000501516TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-5UTRENST00000586023ENST00000479829TADA2Achr17

35818689

+MED24chr17

38192407

-
Frame-shiftENST00000225396ENST00000394126TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000225396ENST00000356271TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000225396ENST00000394128TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000225396ENST00000394127TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000225396ENST00000501516TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-5UTRENST00000225396ENST00000479829TADA2Achr17

35818689

+MED24chr17

38192407

-
Frame-shiftENST00000417170ENST00000394126TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000417170ENST00000356271TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000417170ENST00000394128TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000417170ENST00000394127TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-intronENST00000417170ENST00000501516TADA2Achr17

35818689

+MED24chr17

38192407

-
5CDS-5UTRENST00000417170ENST00000479829TADA2Achr17

35818689

+MED24chr17

38192407

-
3UTR-3CDSENST00000591992ENST00000394126TADA2Achr17

35818689

+MED24chr17

38192407

-
3UTR-intronENST00000591992ENST00000356271TADA2Achr17

35818689

+MED24chr17

38192407

-
3UTR-intronENST00000591992ENST00000394128TADA2Achr17

35818689

+MED24chr17

38192407

-
3UTR-intronENST00000591992ENST00000394127TADA2Achr17

35818689

+MED24chr17

38192407

-
3UTR-intronENST00000591992ENST00000501516TADA2Achr17

35818689

+MED24chr17

38192407

-
3UTR-5UTRENST00000591992ENST00000479829TADA2Achr17

35818689

+MED24chr17

38192407

-

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FusionProtFeatures for TADA2A_MED24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TADA2A

O75478

MED24

O75448

Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4. Required for thefunction of some acidic activation domains, which activatetranscription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker regionbetween neighboring nucleosomes. Plays a role in chromatinremodeling. May promote TP53/p53 'Lys-321' acetylation, leading toreduced TP53 stability and transcriptional activity(PubMed:22644376). May also promote XRCC6 acetylation thusfacilitating cell apoptosis in response to DNA damage(PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6,ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}. Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:12218053,ECO:0000269|PubMed:16595664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TADA2A_MED24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TADA2A_MED24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TADA2AEXOC8, FAM107A, HGS, TADA3, MYC, NR3C1, KAT2A, ATXN7, TP53, CTNNB1, KAT2B, MED1, MED26, CCDC101, ERCC4, CDK8, SRSF1, DDX3X, LUC7L, RNF41, DHX16, DDB1, MED29, TRIM28, SNRPA, SSB, NCBP1, PRPF6, CDC40, SRSF3, WDTC1, RBM39, MED30, MED28, PSPC1, TRA2B, TRA2A, RALY, NONO, PRRC2B, PLRG1, HELT, SRSF4, XAB2, MED8, PUF60, MED25, DHX15, RNPS1, SRSF5, EIF3H, SRRM1, LRCH4, MYEF2, RBM14, EIF3I, MED20, EIF3C, EIF3M, SIN3A, EIF3B, EIF3L, PRPF19, HNRNPC, ILF3, CDC5L, AKAP8, MED18, SNW1, HDAC1, MARK3, PABPC1P1, C11orf30, KRT8, POLR2A, SRRM2, MED16, ILF2, HSPA5, MED14, MED31, LUC7L3, DDX5, MED4, SFPQ, MED15, MED17, DDX17, POLR2B, WDR5, HNRNPF, ACTC1, DOCK6, LUZP1, MED27, POLR2C, HNRNPM, MARK2, MED22, MED23, ZZZ3, MED6, MED12, MED13, YEATS2, DR1, MBIP, SUPT3H, TCF3, PAXIP1, HSP90AA1, HNF4A, LYN, MCPH1, USP22, ARNT2, PRKAB2, KPNA2, MAGOH, MFAP1, EIF4E2, MTX2, FARS2, SF3A3, ZFYVE26, PPP1R16B, PRPF31, CCHCR1, C1orf109, CDCA7L, GPSM3, TTC23, FBF1, KLC4, LOC149950, TEKT4, ZNF564, TTC9C, KLHL38, FAM127C, PSME3, CARD8, PSMC3, IKZF5, CDH19MED24MED10, MED9, MED29, MED19, MED28, MED26, CDK8, THRA, VDR, PPARA, PPARG, RXRA, MED1, HNF4A, ESR1, ESR2, MED30, BRD4, RPAP2, AR, PARP1, SMAD1, SMAD2, SMAD3, TRRAP, SREBF1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TRA, MED14, GSK3B, TNFSF11, RPS6KA6, CTDP1, APP, MED13, MED8, MED16, MED17, MED4, MED11, MED21, MED22, PPP6R1, TFIP11, FBXW7, EPAS1, CDK19, MED7, CCNC, NR1I3, TCL1B, MED15, MED20, MED23, MED6, MED25, MED27, KPNB1, XRCC3, EMC2, PPP4R1, ZWINT, KIFAP3, MMGT1, SUCO, LMO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TADA2A_MED24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TADA2A_MED24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource