FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37048

FusionGeneSummary for TACC3_TMEM129

check button Fusion gene summary
Fusion gene informationFusion gene name: TACC3_TMEM129
Fusion gene ID: 37048
HgeneTgene
Gene symbol

TACC3

TMEM129

Gene ID

10460

92305

Gene nametransforming acidic coiled-coil containing protein 3transmembrane protein 129
SynonymsERIC-1|ERIC1D4S2561E
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptiontransforming acidic coiled-coil-containing protein 3E3 ubiquitin-protein ligase TM129RING-type E3 ubiquitin transferase TM129transmembrane protein 129, E3 ubiquitin protein ligase
Modification date2018052320180523
UniProtAcc

Q9Y6A5

A0AVI4

Ensembl transtripts involved in fusion geneENST00000313288, ENST00000303277, 
ENST00000382936, ENST00000536901, 
Fusion gene scores* DoF score2 X 5 X 5=502 X 1 X 2=4
# samples 52
** MAII scorelog2(5/50*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: TACC3 [Title/Abstract] AND TMEM129 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMEM129

GO:0000209

protein polyubiquitination

24807418


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A8GR-06ATACC3chr4

1739429

+TMEM129chr4

1720353

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313288ENST00000303277TACC3chr4

1739429

+TMEM129chr4

1720353

-
Frame-shiftENST00000313288ENST00000382936TACC3chr4

1739429

+TMEM129chr4

1720353

-
Frame-shiftENST00000313288ENST00000536901TACC3chr4

1739429

+TMEM129chr4

1720353

-

Top

FusionProtFeatures for TACC3_TMEM129


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TACC3

Q9Y6A5

TMEM129

A0AVI4

Plays a role in the microtubule-dependent coupling ofthe nucleus and the centrosome. Involved in the processes thatregulate centrosome-mediated interkinetic nuclear migration (INM)of neural progenitors (By similarity). Acts as component of theTACC3/ch-TOG/clathrin complex proposed to contribute tostabilization of kinetochore fibers of the mitotic spindle byacting as inter-microtubule bridge. The TACC3/ch-TOG/clathrincomplex is required for the maintenance of kinetochore fibertension (PubMed:21297582, PubMed:23532825). May be involved in thecontrol of cell growth and differentiation. May contribute tocancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11,ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582,ECO:0000269|PubMed:23532825}. E3 ubiquitin-protein ligase involved in ER-associatedprotein degradation, preferentially associates with the E2 enzymeUBE2J2. Exploited by viral US11 proteins to mediate HLA class Iproteins degradation. {ECO:0000269|PubMed:24807418}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TACC3_TMEM129


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TACC3_TMEM129


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TACC3AKAP9, TTF2, NDEL1, MBD2, CKAP5, KAT2A, KAT2B, RAE1, AHCYL1, SRXN1, SEC23A, RAD23B, CPLX1, UBA2, RAD23A, RAB14, SSSCA1, PAICS, SEC24A, AURKA, ARNT2, VPS37C, TBC1D22B, KIZ, ASPSCR1, CIB3, SNX20, FZR1, SNAP29, PLEKHO2, C17orf59, MRE11A, NTRK1, ADAR, CALD1, CUX1, KIF11, PCDH7, VASP, SLBP, NFS1, XPR1, DHRS2, ZER1, SLAIN2, ARX, BOD1L1, ORC3, ENAH, METTL14, RNF123, PDF, PANK2, RNF135, KIAA1804, PRMT9, DEPDC7, RNF168, WDR90, C2orf69, PRR14L, FRYL, FAM111B, MIA3, CRISP2, CORO6, SPERT, EVL, HSPA8, MVK, HSPBP1, OIP5, GTF2E2, ZFC3H1, CDC27TMEM129PSMD4, UBE2D3, UBE2J2, DERL1, DERL2, VIMP, VCP, SEL1L, SYVN1, HLA-A, TMEM129, UBE2D1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TACC3_TMEM129


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TACC3_TMEM129


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTACC3C0005695Bladder Neoplasm1CTD_human
HgeneTACC3C0007138Carcinoma, Transitional Cell1CTD_human