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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37038

FusionGeneSummary for TACC2_ATE1

check button Fusion gene summary
Fusion gene informationFusion gene name: TACC2_ATE1
Fusion gene ID: 37038
HgeneTgene
Gene symbol

TACC2

ATE1

Gene ID

10579

11101

Gene nametransforming acidic coiled-coil containing protein 2arginyltransferase 1
SynonymsAZU-1|ECTACC-
Cytomap

10q26.13

10q26.13

Type of geneprotein-codingprotein-coding
Descriptiontransforming acidic coiled-coil-containing protein 2anti zuai-1arginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferase
Modification date2018052320180523
UniProtAcc

O95359

O95260

Ensembl transtripts involved in fusion geneENST00000369005, ENST00000513429, 
ENST00000515273, ENST00000515603, 
ENST00000453444, ENST00000358010, 
ENST00000334433, ENST00000369001, 
ENST00000369000, ENST00000360561, 
ENST00000368999, ENST00000369004, 
ENST00000260733, ENST00000493951, 
ENST00000369043, ENST00000535655, 
ENST00000224652, ENST00000369040, 
ENST00000540606, ENST00000543447, 
ENST00000481784, 
Fusion gene scores* DoF score9 X 9 X 6=4866 X 4 X 4=96
# samples 126
** MAII scorelog2(12/486*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TACC2 [Title/Abstract] AND ATE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A07C-01ATACC2chr10

123892249

+ATE1chr10

123629553

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369005ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000369005ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000369005ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000369005ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000369005ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000369005ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000369005ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000513429ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000513429ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000513429ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000513429ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000513429ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000513429ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000513429ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515273ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515273ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515273ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515273ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515273ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515273ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000515273ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515603ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515603ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515603ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515603ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515603ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000515603ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000515603ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000453444ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000453444ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000453444ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000453444ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000453444ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000453444ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000453444ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000358010ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000358010ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000358010ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000358010ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000358010ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000358010ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000358010ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000334433ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000334433ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000334433ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000334433ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000334433ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
Frame-shiftENST00000334433ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5CDS-5UTRENST00000334433ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369001ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369001ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369001ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369001ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369001ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369001ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-5UTRENST00000369001ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369000ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369000ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369000ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369000ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369000ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-3CDSENST00000369000ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
5UTR-5UTRENST00000369000ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000360561ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000360561ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000360561ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000360561ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000360561ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000360561ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-5UTRENST00000360561ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000368999ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000368999ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000368999ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000368999ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000368999ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000368999ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-5UTRENST00000368999ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000369004ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000369004ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000369004ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000369004ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000369004ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000369004ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-5UTRENST00000369004ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000260733ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000260733ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000260733ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000260733ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000260733ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000260733ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-5UTRENST00000260733ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000493951ENST00000369043TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000493951ENST00000535655TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000493951ENST00000224652TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000493951ENST00000369040TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000493951ENST00000540606TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-3CDSENST00000493951ENST00000543447TACC2chr10

123892249

+ATE1chr10

123629553

-
intron-5UTRENST00000493951ENST00000481784TACC2chr10

123892249

+ATE1chr10

123629553

-

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FusionProtFeatures for TACC2_ATE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TACC2

O95359

ATE1

O95260

Involved in the post-translational conjugation ofarginine to the N-terminal aspartate or glutamate of a protein.This arginylation is required for degradation of the protein viathe ubiquitin pathway. Does not arginylate cysteine residues (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TACC2_ATE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TACC2_ATE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TACC2YEATS4, SMARCB1, HMG20B, CKAP5, KAT2A, KAT2B, EP300, CREBBP, PRC1, NUP155, PPP1CC, AURKC, TTK, TACC1, CTR9, KIF21A, SLAIN2, TRIM25ATE1RAE1, SUV39H1, EHD1, HLA-DQB2, C14orf105, CNN2, CLDN10, VPS26B, MRM1, MAPK8, POU2AF1, FAM219A, TEX33, REG4, GAST, DPH3, QKI, AVP, EXT2, RAB7B, P2RX1, C16orf45, PLA2G10, RAB5A, GPR37, TOB1, PTPN14, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TACC2_ATE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TACC2_ATE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource