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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37018

FusionGeneSummary for TAB1_PICK1

check button Fusion gene summary
Fusion gene informationFusion gene name: TAB1_PICK1
Fusion gene ID: 37018
HgeneTgene
Gene symbol

TAB1

PICK1

Gene ID

10454

9463

Gene nameTGF-beta activated kinase 1 (MAP3K7) binding protein 1protein interacting with PRKCA 1
Synonyms3'-Tab1|MAP3K7IP1PICK|PRKCABP
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
DescriptionTGF-beta-activated kinase 1 and MAP3K7-binding protein 1TAK1-binding protein 1mitogen-activated protein kinase kinase kinase 7-interacting protein 1transforming growth factor beta-activated kinase-binding protein 1PRKCA-binding proteinprotein interacting with C kinase 1protein kinase C-alpha-binding protein
Modification date2018052220180523
UniProtAcc

Q15750

Q9NRD5

Ensembl transtripts involved in fusion geneENST00000216160, ENST00000331454, 
ENST00000488859, 
ENST00000404072, 
ENST00000468288, ENST00000356976, 
Fusion gene scores* DoF score5 X 4 X 5=1002 X 2 X 2=8
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TAB1 [Title/Abstract] AND PICK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePICK1

GO:0007205

protein kinase C-activating G-protein coupled receptor signaling pathway

10623590

TgenePICK1

GO:0015844

monoamine transport

11343649


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-26-5133-01ATAB1chr22

39817976

+PICK1chr22

38467689

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000216160ENST00000404072TAB1chr22

39817976

+PICK1chr22

38467689

+
5CDS-intronENST00000216160ENST00000468288TAB1chr22

39817976

+PICK1chr22

38467689

+
5CDS-intronENST00000216160ENST00000356976TAB1chr22

39817976

+PICK1chr22

38467689

+
Frame-shiftENST00000331454ENST00000404072TAB1chr22

39817976

+PICK1chr22

38467689

+
5CDS-intronENST00000331454ENST00000468288TAB1chr22

39817976

+PICK1chr22

38467689

+
5CDS-intronENST00000331454ENST00000356976TAB1chr22

39817976

+PICK1chr22

38467689

+
intron-3CDSENST00000488859ENST00000404072TAB1chr22

39817976

+PICK1chr22

38467689

+
intron-intronENST00000488859ENST00000468288TAB1chr22

39817976

+PICK1chr22

38467689

+
intron-intronENST00000488859ENST00000356976TAB1chr22

39817976

+PICK1chr22

38467689

+

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FusionProtFeatures for TAB1_PICK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAB1

Q15750

PICK1

Q9NRD5

May be an important signaling intermediate between TGFBreceptors and MAP3K7/TAK1. May play an important role in mammalianembryogenesis. Probable adapter protein that bind to and organize thesubcellular localization of a variety of membrane proteinscontaining some PDZ recognition sequence. Involved in theclustering of various receptors, possibly by acting at thereceptor internalization level. Plays a role in synapticplasticity by regulating the trafficking and internalization ofAMPA receptors. May be regulated upon PRKCA activation. Mayregulate ASIC1/ASIC3 channel. Regulates actin polymerization byinhibiting the actin-nucleating activity of the Arp2/3 complex;the function is competetive with nucleation promoting factors andis linked to neuronal morphology regulation and AMPA receptor(AMPAR) endocytosis. Via interaction with the Arp2/3 complexinvolved in regulation of synaptic plasicity of excitatorysynapses and required for spine shrinkage during long-termdepression (LTD). Involved in regulation of astrocyte morphology,antagonistic to Arp2/3 complex activator WASL/N-WASP function.{ECO:0000269|PubMed:20403402}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAB1_PICK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAB1_PICK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAB1TAB2, TRAF2, MAP3K7, TAB3, SMAD7, XIAP, SMAD6, MAPK14, ZMYND11, TRAF6, TNF, AGO3, RIPK2, MORF4L1, MORF4L2, MTG2, PHACTR3, C9orf78, CARD11, PDCD6IP, CASP6, PPP1R7, GIT1, XPO7, NXPH3, URB1, PHC2, POLR3D, RPL10, ACAP3, SERPINA4, CKB, CFL1, DBN1, MICAL1, KIFC2, MON1A, LAP3, ASRGL1, RBX1, MAPKAPK5, POLDIP2, FADD, LCMT1, PTPMT1, EPRS, C2orf44, HNRNPR, ARAP1, RPLP1, SNRNP35, TSSC4, TRPC4AP, PRKAR1A, ARRB2, NR2C2, OGT, GRK5, EGFR, IKBKB, NOTCH1, BST2, HSP90AA1, MAPK12, MAPK8IP1, GRB2, BIRC3, NPM1, TRIP6, CDK5RAP3, WTAP, PPP2CB, PPP2R1A, FN1, CORO1A, SLMAP, MDM2, TIRAP, BAG2, MAGED1, NAIP, BIRC7, SHMT2, MOV10, NXF1, IKBKG, MAP3K1, C11orf70, MAMDC2, RFPL4B, CARD8, PRMT2, C9orf41, TMEM52B, SSX2IP, CNTROB, XPO1, HSPA1L, MAPK11, ITCH, ALKBH3, MCM2, USP18, F2R, SMURF1, MTMR8, EMILIN1, SYNC, AARSD1, SERPINB2, SCRN1, CCDC102B, MANSC1, PCDH20, TBL1Y, HSPA8, CYB5A, GANAB, HSPBP1, TH, PCDHGB4, PSMC3, KLHL10, CCL22, C6orf141, CRYBB3, UBC, AATK, ERBB4, ROR2, CYLD, PARK7, SOD1PICK1GRIK2, GRIK1, ASIC1, GRM7, PRKCA, PRLHR, ERBB2, ERBB2IP, GRIA4, GRIA2, GRIA3, GRIA1, GRM3, BNC1, SLC6A3, PARK2, UBQLN4, APTX, ATXN1L, ATXN3, ATXN7, ATXN7L3, CIC, COIL, FXN, GFI1, GFI1B, PRKCG, SACS, USP7, KLHL24, EHD2, GPR37, BIN3, MAGEA1, ATP6AP2, RASSF7, FHOD1, EPHA7, UACA, ZNF24, ICA1L, ICA1, KLHL11, CEP89, FAM117A, GNPTAB, ITGA6, F11R, QSOX2, ARFIP1, AAED1, EFNB1, PKD2, NDRG3, ATP6AP1, NFS1, GPATCH2, ATP11A, AMIGO1, PVRL2, EFNB2, DSE, UGCG, AKT1, TCP10L, DPEP1, LDB1, ILVBL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAB1_PICK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAB1_PICK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAB1C0032460Polycystic Ovary Syndrome1CTD_human
TgenePICK1C0036341Schizophrenia4PSYGENET
TgenePICK1C0033941Psychoses, Substance-Induced1CTD_human
TgenePICK1C0033975Psychotic Disorders1PSYGENET
TgenePICK1C0236733Amphetamine-Related Disorders1CTD_human
TgenePICK1C0349204Nonorganic psychosis1PSYGENET