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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36973

FusionGeneSummary for SYT14_ANKHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: SYT14_ANKHD1
Fusion gene ID: 36973
HgeneTgene
Gene symbol

SYT14

ANKHD1

Gene ID

255928

54882

Gene namesynaptotagmin 14ankyrin repeat and KH domain containing 1
SynonymsSCAR11|sytXIVMASK|MASK1|PP2500|VBARP
Cytomap

1q32.2

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionsynaptotagmin-14synaptotagmin XIVankyrin repeat and KH domain-containing protein 1HIV-1 Vpr-binding ankyrin repeat proteinmultiple ankyrin repeats, single KH-domain homolog
Modification date2018052320180523
UniProtAcc

Q8NB59

Q8IWZ3

Ensembl transtripts involved in fusion geneENST00000534859, ENST00000399639, 
ENST00000422431, ENST00000537238, 
ENST00000367019, ENST00000472886, 
ENST00000271745, ENST00000367015, 
ENST00000360839, ENST00000297183, 
ENST00000394723, ENST00000394722, 
ENST00000462121, ENST00000544120, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 11 X 3=264
# samples 211
** MAII scorelog2(2/8*10)=1.32192809488736log2(11/264*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYT14 [Title/Abstract] AND ANKHD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE148552SYT14chr1

210257196

-ANKHD1chr5

139894530

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000534859ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000534859ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000534859ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000534859ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000534859ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000534859ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000399639ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000399639ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000399639ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000399639ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000399639ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000399639ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000422431ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000422431ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000422431ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000422431ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000422431ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000422431ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000537238ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000537238ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000537238ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000537238ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000537238ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000537238ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367019ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367019ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367019ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367019ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367019ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367019ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000472886ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000472886ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000472886ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000472886ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000472886ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000472886ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000271745ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000271745ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000271745ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000271745ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000271745ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000271745ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367015ENST00000360839SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367015ENST00000297183SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367015ENST00000394723SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367015ENST00000394722SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367015ENST00000462121SYT14chr1

210257196

-ANKHD1chr5

139894530

-
intron-intronENST00000367015ENST00000544120SYT14chr1

210257196

-ANKHD1chr5

139894530

-

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FusionProtFeatures for SYT14_ANKHD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYT14

Q8NB59

ANKHD1

Q8IWZ3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SYT14_ANKHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYT14_ANKHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYT14_ANKHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYT14_ANKHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYT14C3280226SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 111ORPHANET;UNIPROT