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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36968

FusionGeneSummary for SYS1_TAF15

check button Fusion gene summary
Fusion gene informationFusion gene name: SYS1_TAF15
Fusion gene ID: 36968
HgeneTgene
Gene symbol

SYS1

TAF15

Gene ID

90196

8148

Gene nameSYS1, golgi trafficking proteinTATA-box binding protein associated factor 15
SynonymsC20orf169|dJ453C12.4|dJ453C12.4.1Npl3|RBP56|TAF2N|TAFII68
Cytomap

20q13.12

17q12

Type of geneprotein-codingprotein-coding
Descriptionprotein SYS1 homologSYS1 Golgi-localized integral membrane protein homologSys1 golgi trafficking proteinTATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin
Modification date2018052320180523
UniProtAcc

Q8N2H4

Q92804

Ensembl transtripts involved in fusion geneENST00000372727, ENST00000414310, 
ENST00000243918, ENST00000426004, 
ENST00000479779, 
ENST00000588240, 
ENST00000592237, ENST00000311979, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 5 X 6=210
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYS1 [Title/Abstract] AND TAF15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-CS-5397-01ASYS1chr20

43992333

+TAF15chr17

34169371

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000372727ENST00000588240SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000372727ENST00000592237SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000372727ENST00000311979SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000414310ENST00000588240SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000414310ENST00000592237SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000414310ENST00000311979SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000243918ENST00000588240SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000243918ENST00000592237SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000243918ENST00000311979SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000426004ENST00000588240SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000426004ENST00000592237SYS1chr20

43992333

+TAF15chr17

34169371

+
Frame-shitENST00000426004ENST00000311979SYS1chr20

43992333

+TAF15chr17

34169371

+
intron-3CDSENST00000479779ENST00000588240SYS1chr20

43992333

+TAF15chr17

34169371

+
intron-3CDSENST00000479779ENST00000592237SYS1chr20

43992333

+TAF15chr17

34169371

+
intron-3CDSENST00000479779ENST00000311979SYS1chr20

43992333

+TAF15chr17

34169371

+

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FusionProtFeatures for SYS1_TAF15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYS1

Q8N2H4

TAF15

Q92804

Involved in protein trafficking. May serve as a receptorfor ARFRP1. RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269|PubMed:19124016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SYS1_TAF15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYS1_TAF15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SYS1TAF15SAFB, PRMT1, TAF7, TAF5, TAF13, TAF11, POLR2C, POLR2G, POLR2E, SF1, KAT2B, POLR2A, HIST2H2AC, HIST1H3A, HIST2H4A, CACNA1A, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDB1, TPR, SAP30BP, RNF168, SCARB2, TPM2, TMED9, MED26, PRMT8, FUS, RPA3, RPA2, RPA1, HIST3H3, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, RPS6KB2, ACAA2, SFN, HNRNPA1, PPP1CB, MATR3, MED12, MCM2, NF2, DNPEP, KLHL8, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYS1_TAF15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYS1_TAF15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAF15C0029463Osteosarcoma1CTD_human
TgeneTAF15C0038356Stomach Neoplasms1CTD_human