FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36877

FusionGeneSummary for SYMPK_RPRD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SYMPK_RPRD2
Fusion gene ID: 36877
HgeneTgene
Gene symbol

SYMPK

RPRD2

Gene ID

8189

23248

Gene namesymplekinregulation of nuclear pre-mRNA domain containing 2
SynonymsSPK|SYMHSPC099|KIAA0460
Cytomap

19q13.32

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionsymplekinregulation of nuclear pre-mRNA domain-containing protein 2
Modification date2018051920180519
UniProtAcc

Q92797

Q5VT52

Ensembl transtripts involved in fusion geneENST00000598155, ENST00000245934, 
ENST00000492220, ENST00000401000, 
ENST00000539519, ENST00000369067, 
ENST00000369068, 
Fusion gene scores* DoF score9 X 7 X 6=3788 X 5 X 7=280
# samples 88
** MAII scorelog2(8/378*10)=-2.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYMPK [Title/Abstract] AND RPRD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYMPK

GO:0035307

positive regulation of protein dephosphorylation

20861839


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-PG-A915-01ASYMPKchr19

46366316

-RPRD2chr1

150390072

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000598155ENST00000492220SYMPKchr19

46366316

-RPRD2chr1

150390072

+
intron-3UTRENST00000598155ENST00000401000SYMPKchr19

46366316

-RPRD2chr1

150390072

+
intron-3UTRENST00000598155ENST00000539519SYMPKchr19

46366316

-RPRD2chr1

150390072

+
intron-3UTRENST00000598155ENST00000369067SYMPKchr19

46366316

-RPRD2chr1

150390072

+
intron-3UTRENST00000598155ENST00000369068SYMPKchr19

46366316

-RPRD2chr1

150390072

+
5UTR-3UTRENST00000245934ENST00000492220SYMPKchr19

46366316

-RPRD2chr1

150390072

+
5UTR-3UTRENST00000245934ENST00000401000SYMPKchr19

46366316

-RPRD2chr1

150390072

+
5UTR-3UTRENST00000245934ENST00000539519SYMPKchr19

46366316

-RPRD2chr1

150390072

+
5UTR-3UTRENST00000245934ENST00000369067SYMPKchr19

46366316

-RPRD2chr1

150390072

+
5UTR-3UTRENST00000245934ENST00000369068SYMPKchr19

46366316

-RPRD2chr1

150390072

+

Top

FusionProtFeatures for SYMPK_RPRD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYMPK

Q92797

RPRD2

Q5VT52

Scaffold protein that functions as a component of amultimolecular complex involved in histone mRNA 3'-end processing.Specific component of the tight junction (TJ) plaque, but mightnot be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. EnhancesSSU72 phosphatase activity. {ECO:0000269|PubMed:16230528,ECO:0000269|PubMed:20861839}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SYMPK_RPRD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SYMPK_RPRD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SYMPKHSF1, CSTF2, SMARCAD1, SIRT7, TOP1, CPSF3, CPSF2, SSU72, WWOX, RPA1, RPA2, RPA3, KAT6A, KMT2A, VCP, UBE2I, BSG, TMEM171, LYPD3, RP2, KLHDC3, CPSF4, CPSF1, KHSRP, USP24, WDR33, NTRK1, RIN3, CLK1, CSTF3, FN1, P4HB, MKNK2, MAPK3, VPS26A, FIP1L1, KLC3, CEP170P1, ELMO3, FOXB1, FOXE1, FOXG1, FOXH1, FOXI2, FOXL1, FOXQ1, SNW1, CDC5L, CPEB1, CSTF2T, SIGLECL1, IL13RA2, PDHA1RPRD2PPP1CA, ELAVL1, DGCR8, PPP1CC, CSNK2A1, MPG, UPF1, WWOX, RPA3, RPA2, RPA1, RPRD1B, POLR2G, NTRK1, B9D2, XPO1, DYNC1H1, NCBP1, SUPT5H, CTR9, LEO1, TSSC1, STRAP, HIF1AN, HSPA8, LMO2, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SYMPK_RPRD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SYMPK_RPRD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYMPKC0038356Stomach Neoplasms1CTD_human