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Fusion gene ID: 36876 |
FusionGeneSummary for SYMPK_MAPK6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYMPK_MAPK6 | Fusion gene ID: 36876 | Hgene | Tgene | Gene symbol | SYMPK | MAPK6 | Gene ID | 8189 | 5597 |
| Gene name | symplekin | mitogen-activated protein kinase 6 | |
| Synonyms | SPK|SYM | ERK3|HsT17250|PRKM6|p97MAPK | |
| Cytomap | 19q13.32 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | symplekin | mitogen-activated protein kinase 6ERK-3MAP kinase 6MAP kinase isoform p97MAPK 6extracellular signal-regulated kinase 3extracellular signal-regulated kinase, p97p97-MAPKprotein kinase, mitogen-activated 5protein kinase, mitogen-activated 6 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q92797 | Q16659 | |
| Ensembl transtripts involved in fusion gene | ENST00000598155, ENST00000245934, | ENST00000261845, ENST00000558841, | |
| Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/378*10)=-2.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SYMPK [Title/Abstract] AND MAPK6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SYMPK | GO:0035307 | positive regulation of protein dephosphorylation | 20861839 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | L77964 | SYMPK | chr19 | 46351190 | - | MAPK6 | chr15 | 52311447 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000598155 | ENST00000261845 | SYMPK | chr19 | 46351190 | - | MAPK6 | chr15 | 52311447 | + |
| intron-intron | ENST00000598155 | ENST00000558841 | SYMPK | chr19 | 46351190 | - | MAPK6 | chr15 | 52311447 | + |
| intron-5UTR | ENST00000245934 | ENST00000261845 | SYMPK | chr19 | 46351190 | - | MAPK6 | chr15 | 52311447 | + |
| intron-intron | ENST00000245934 | ENST00000558841 | SYMPK | chr19 | 46351190 | - | MAPK6 | chr15 | 52311447 | + |
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FusionProtFeatures for SYMPK_MAPK6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYMPK | MAPK6 |
| Scaffold protein that functions as a component of amultimolecular complex involved in histone mRNA 3'-end processing.Specific component of the tight junction (TJ) plaque, but mightnot be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. EnhancesSSU72 phosphatase activity. {ECO:0000269|PubMed:16230528,ECO:0000269|PubMed:20861839}. | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of thecomplex formed with MAPKAPK5 is still unclear, but the complexfollows a complex set of phosphorylation events: upon interactionwith atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189and then mediates phosphorylation and activation of MAPKAPK5,which in turn phosphorylates ERK3/MAPK6. May promote entry in thecell cycle (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYMPK_MAPK6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SYMPK_MAPK6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYMPK_MAPK6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYMPK_MAPK6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SYMPK | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | MAPK6 | C0020507 | Hyperplasia | 1 | CTD_human |
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