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Fusion gene ID: 36870 |
FusionGeneSummary for SYK_SYK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYK_SYK | Fusion gene ID: 36870 | Hgene | Tgene | Gene symbol | SYK | SYK | Gene ID | 6850 | 6850 |
| Gene name | spleen associated tyrosine kinase | spleen associated tyrosine kinase | |
| Synonyms | p72-Syk | p72-Syk | |
| Cytomap | 9q22.2 | 9q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase SYKspleen tyrosine kinase | tyrosine-protein kinase SYKspleen tyrosine kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P43405 | P43405 | |
| Ensembl transtripts involved in fusion gene | ENST00000375751, ENST00000375754, ENST00000375747, ENST00000476708, ENST00000375746, | ENST00000375751, ENST00000375754, ENST00000375747, ENST00000476708, ENST00000375746, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 4=80 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SYK [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SYK | GO:0006468 | protein phosphorylation | 17681949 |
| Hgene | SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
| Hgene | SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
| Tgene | SYK | GO:0006468 | protein phosphorylation | 17681949 |
| Tgene | SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
| Tgene | SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB242349 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000375751 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375751 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375751 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375751 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375751 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375754 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375747 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-intron | ENST00000476708 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375746 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
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FusionProtFeatures for SYK_SYK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYK | SYK |
| Non-receptor tyrosine kinase which mediates signaltransduction downstream of a variety of transmembrane receptorsincluding classical immunoreceptors like the B-cell receptor(BCR). Regulates several biological processes including innate andadaptive immunity, cell adhesion, osteoclast maturation, plateletactivation and vascular development. Assembles into signalingcomplexes with activated receptors at the plasma membrane viainteraction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor canalso be indirect and mediated by adapter proteins containing ITAMor partial hemITAM domains. The phosphorylation of the ITAMdomains is generally mediated by SRC subfamily kinases uponengagement of the receptor. More rarely signal transduction viaSYK could be ITAM-independent. Direct downstream effectorsphosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 andBLNK. Initially identified as essential in B-cell receptor (BCR)signaling, it is necessary for the maturation of B-cells mostprobably at the pro-B to pre-B transition. Activated upon BCRengagement, it phosphorylates and activates BLNK an adapterlinking the activated BCR to downstream signaling adapters andeffectors. It also phosphorylates and activates PLCG1 and the PKCsignaling pathway. It also phosphorylates BTK and regulates itsactivity in B-cell antigen receptor (BCR)-coupled signaling. Inaddition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innateimmune response to fungal, bacterial and viral pathogens. It isfor instance activated by the membrane lectin CLEC7A. Uponstimulation by fungal proteins, CLEC7A together with SYK activatesimmune cells inducing the production of ROS. Also activates theinflammasome and NF-kappa-B-mediated transcription of chemokinesand cytokines in presence of pathogens. Regulates neutrophildegranulation and phagocytosis through activation of the MAPKsignaling cascade. Also mediates the activation of dendritic cellsby cell necrosis stimuli. Also involved in mast cells activation.Involved in interleukin-3/IL3-mediated signaling pathway inbasophils (By similarity). Also functions downstream of receptorsmediating cell adhesion. Relays for instance, integrin-mediatedneutrophils and macrophages activation and P-selectinreceptor/SELPG-mediated recruitment of leukocytes to inflammatoryloci. Plays also a role in non-immune processes. It is forinstance involved in vascular development where it may regulateblood and lymphatic vascular separation. It is also required forosteoclast development and function. Functions in the activationof platelets by collagen, mediating PLCG2 phosphorylation andactivation. May be coupled to the collagen receptor by the ITAMdomain-containing FCER1G. Also activated by the membrane lectinCLEC1B that is required for activation of platelets byPDPN/podoplanin. Involved in platelet adhesion being activated byITGB3 engaged by fibrinogen. Together with CEACAM20, enhancesproduction of the cytokine CXCL8/IL-8 via the NFKB pathway and maythus have a role in the intestinal immune response (Bysimilarity). {ECO:0000250|UniProtKB:P48025,ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653,ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739,ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. | Non-receptor tyrosine kinase which mediates signaltransduction downstream of a variety of transmembrane receptorsincluding classical immunoreceptors like the B-cell receptor(BCR). Regulates several biological processes including innate andadaptive immunity, cell adhesion, osteoclast maturation, plateletactivation and vascular development. Assembles into signalingcomplexes with activated receptors at the plasma membrane viainteraction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor canalso be indirect and mediated by adapter proteins containing ITAMor partial hemITAM domains. The phosphorylation of the ITAMdomains is generally mediated by SRC subfamily kinases uponengagement of the receptor. More rarely signal transduction viaSYK could be ITAM-independent. Direct downstream effectorsphosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 andBLNK. Initially identified as essential in B-cell receptor (BCR)signaling, it is necessary for the maturation of B-cells mostprobably at the pro-B to pre-B transition. Activated upon BCRengagement, it phosphorylates and activates BLNK an adapterlinking the activated BCR to downstream signaling adapters andeffectors. It also phosphorylates and activates PLCG1 and the PKCsignaling pathway. It also phosphorylates BTK and regulates itsactivity in B-cell antigen receptor (BCR)-coupled signaling. Inaddition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innateimmune response to fungal, bacterial and viral pathogens. It isfor instance activated by the membrane lectin CLEC7A. Uponstimulation by fungal proteins, CLEC7A together with SYK activatesimmune cells inducing the production of ROS. Also activates theinflammasome and NF-kappa-B-mediated transcription of chemokinesand cytokines in presence of pathogens. Regulates neutrophildegranulation and phagocytosis through activation of the MAPKsignaling cascade. Also mediates the activation of dendritic cellsby cell necrosis stimuli. Also involved in mast cells activation.Involved in interleukin-3/IL3-mediated signaling pathway inbasophils (By similarity). Also functions downstream of receptorsmediating cell adhesion. Relays for instance, integrin-mediatedneutrophils and macrophages activation and P-selectinreceptor/SELPG-mediated recruitment of leukocytes to inflammatoryloci. Plays also a role in non-immune processes. It is forinstance involved in vascular development where it may regulateblood and lymphatic vascular separation. It is also required forosteoclast development and function. Functions in the activationof platelets by collagen, mediating PLCG2 phosphorylation andactivation. May be coupled to the collagen receptor by the ITAMdomain-containing FCER1G. Also activated by the membrane lectinCLEC1B that is required for activation of platelets byPDPN/podoplanin. Involved in platelet adhesion being activated byITGB3 engaged by fibrinogen. Together with CEACAM20, enhancesproduction of the cytokine CXCL8/IL-8 via the NFKB pathway and maythus have a role in the intestinal immune response (Bysimilarity). {ECO:0000250|UniProtKB:P48025,ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653,ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739,ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYK_SYK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SYK_SYK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYK_SYK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYK_SYK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SYK | C0025202 | melanoma | 1 | CTD_human |
| Hgene | SYK | C0025500 | Mesothelioma | 1 | CTD_human |
| Tgene | SYK | C0025202 | melanoma | 1 | CTD_human |
| Tgene | SYK | C0025500 | Mesothelioma | 1 | CTD_human |
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