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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36821

FusionGeneSummary for SUV420H1_SLITRK4

check button Fusion gene summary
Fusion gene informationFusion gene name: SUV420H1_SLITRK4
Fusion gene ID: 36821
HgeneTgene
Gene symbol

SUV420H1

SLITRK4

Gene ID

51111

139065

Gene namelysine methyltransferase 5BSLIT and NTRK like family member 4
SynonymsCGI-85|CGI85|MRD51|SUV420H1-
Cytomap

11q13.2

Xq27.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase KMT5Bhistone-lysine N-methyltransferase SUV420H1lysine (K)-specific methyltransferase 5Blysine N-methyltransferase 5Blysine-specific methyltransferase 5Bsu(var)4-20 homolog 1suppressor of variegation 4-20 homolog 1SLIT and NTRK-like protein 4slit and trk like gene 4
Modification date2018052420180523
UniProtAcc

Q8IW52

Ensembl transtripts involved in fusion geneENST00000304363, ENST00000401547, 
ENST00000405515, ENST00000402789, 
ENST00000402185, 
ENST00000381779, 
ENST00000338017, ENST00000356928, 
Fusion gene scores* DoF score8 X 3 X 7=1681 X 1 X 1=1
# samples 81
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SUV420H1 [Title/Abstract] AND SLITRK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2766-01ASUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000304363ENST00000381779SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
intron-5UTRENST00000304363ENST00000338017SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
intron-5UTRENST00000304363ENST00000356928SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
intron-5UTRENST00000401547ENST00000381779SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
intron-5UTRENST00000401547ENST00000338017SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
intron-5UTRENST00000401547ENST00000356928SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000405515ENST00000381779SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000405515ENST00000338017SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000405515ENST00000356928SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000402789ENST00000381779SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000402789ENST00000338017SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000402789ENST00000356928SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000402185ENST00000381779SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000402185ENST00000338017SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-
5UTR-5UTRENST00000402185ENST00000356928SUV420H1chr11

67980944

-SLITRK4chrX

142718974

-

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FusionProtFeatures for SUV420H1_SLITRK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUV420H1

SLITRK4

Q8IW52

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. It is involved in synaptogenesis and promotes synapsedifferentiation (PubMed:27812321). Suppresses neurite outgrowth(By similarity). {ECO:0000250|UniProtKB:Q810B8,ECO:0000269|PubMed:27812321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SUV420H1_SLITRK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SUV420H1_SLITRK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SUV420H1YWHAQ, HIST1H4A, SMARCD1, ESR1, SUV420H1, BRD1SLITRK4LYN, CNPY3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SUV420H1_SLITRK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SUV420H1_SLITRK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource