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Fusion gene ID: 36814 |
FusionGeneSummary for SUV39H1_SUV39H1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SUV39H1_SUV39H1 | Fusion gene ID: 36814 | Hgene | Tgene | Gene symbol | SUV39H1 | SUV39H1 | Gene ID | 6839 | 6839 |
| Gene name | suppressor of variegation 3-9 homolog 1 | suppressor of variegation 3-9 homolog 1 | |
| Synonyms | H3-K9-HMTase 1|KMT1A|MG44|SUV39H | H3-K9-HMTase 1|KMT1A|MG44|SUV39H | |
| Cytomap | Xp11.23 | Xp11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase SUV39H1Su(var)3-9 homolog 1histone H3-K9 methyltransferase 1histone-lysine N-methyltransferase, H3 lysine-9 specific 1lysine N-methyltransferase 1Aposition-effect variegation 3-9 homolog | histone-lysine N-methyltransferase SUV39H1Su(var)3-9 homolog 1histone H3-K9 methyltransferase 1histone-lysine N-methyltransferase, H3 lysine-9 specific 1lysine N-methyltransferase 1Aposition-effect variegation 3-9 homolog | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | O43463 | O43463 | |
| Ensembl transtripts involved in fusion gene | ENST00000337852, ENST00000376687, ENST00000453214, ENST00000482260, | ENST00000337852, ENST00000376687, ENST00000453214, ENST00000482260, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SUV39H1 [Title/Abstract] AND SUV39H1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SUV39H1 | GO:0000183 | chromatin silencing at rDNA | 18485871 |
| Hgene | SUV39H1 | GO:0006974 | cellular response to DNA damage stimulus | 23509280 |
| Hgene | SUV39H1 | GO:0071456 | cellular response to hypoxia | 21402781 |
| Tgene | SUV39H1 | GO:0000183 | chromatin silencing at rDNA | 18485871 |
| Tgene | SUV39H1 | GO:0006974 | cellular response to DNA damage stimulus | 23509280 |
| Tgene | SUV39H1 | GO:0071456 | cellular response to hypoxia | 21402781 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | L08238 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000337852 | ENST00000337852 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| 5UTR-3CDS | ENST00000337852 | ENST00000376687 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| 5UTR-5UTR | ENST00000337852 | ENST00000453214 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| 5UTR-intron | ENST00000337852 | ENST00000482260 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-3CDS | ENST00000376687 | ENST00000337852 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-3CDS | ENST00000376687 | ENST00000376687 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-5UTR | ENST00000376687 | ENST00000453214 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-intron | ENST00000376687 | ENST00000482260 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-3CDS | ENST00000453214 | ENST00000337852 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-3CDS | ENST00000453214 | ENST00000376687 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-5UTR | ENST00000453214 | ENST00000453214 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-intron | ENST00000453214 | ENST00000482260 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-3CDS | ENST00000482260 | ENST00000337852 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-3CDS | ENST00000482260 | ENST00000376687 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-5UTR | ENST00000482260 | ENST00000453214 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
| intron-intron | ENST00000482260 | ENST00000482260 | SUV39H1 | chrX | 48554098 | - | SUV39H1 | chrX | 48557345 | + |
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FusionProtFeatures for SUV39H1_SUV39H1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SUV39H1 | SUV39H1 |
| Histone methyltransferase that specificallytrimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3'Lys-9' trimethylation represents a specific tag for epigenetictranscriptional repression by recruiting HP1 (CBX1, CBX3 and/orCBX5) proteins to methylated histones. Mainly functions inheterochromatin regions, thereby playing a central role in theestablishment of constitutive heterochromatin at pericentric andtelomere regions. H3 'Lys-9' trimethylation is also required todirect DNA methylation at pericentric repeats. SUV39H1 is targetedto histone H3 via its interaction with RB1 and is involved in manyprocesses, such as repression of MYOD1-stimulated differentiation,regulation of the control switch for exiting the cell cycle andentering differentiation, repression by the PML-RARA fusionprotein, BMP-induced repression, repression of switchrecombination to IgA and regulation of telomere length. Componentof the eNoSC (energy-dependent nucleolar silencing) complex, acomplex that mediates silencing of rDNA in response tointracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energystatus of cell: upon glucose starvation, elevation ofNAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2)by SUV39H1 and the formation of silent chromatin in the rDNAlocus. Recruited by the large PER complex to the E-box elements ofthe circadian target genes such as PER2 itself or PER1,contributes to the conversion of local chromatin to aheterochromatin-like repressive state through H3 'Lys-9'trimethylation. {ECO:0000269|PubMed:14765126,ECO:0000269|PubMed:16449642, ECO:0000269|PubMed:16818776,ECO:0000269|PubMed:16858404, ECO:0000269|PubMed:18004385,ECO:0000269|PubMed:18485871}. | Histone methyltransferase that specificallytrimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3'Lys-9' trimethylation represents a specific tag for epigenetictranscriptional repression by recruiting HP1 (CBX1, CBX3 and/orCBX5) proteins to methylated histones. Mainly functions inheterochromatin regions, thereby playing a central role in theestablishment of constitutive heterochromatin at pericentric andtelomere regions. H3 'Lys-9' trimethylation is also required todirect DNA methylation at pericentric repeats. SUV39H1 is targetedto histone H3 via its interaction with RB1 and is involved in manyprocesses, such as repression of MYOD1-stimulated differentiation,regulation of the control switch for exiting the cell cycle andentering differentiation, repression by the PML-RARA fusionprotein, BMP-induced repression, repression of switchrecombination to IgA and regulation of telomere length. Componentof the eNoSC (energy-dependent nucleolar silencing) complex, acomplex that mediates silencing of rDNA in response tointracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energystatus of cell: upon glucose starvation, elevation ofNAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2)by SUV39H1 and the formation of silent chromatin in the rDNAlocus. Recruited by the large PER complex to the E-box elements ofthe circadian target genes such as PER2 itself or PER1,contributes to the conversion of local chromatin to aheterochromatin-like repressive state through H3 'Lys-9'trimethylation. {ECO:0000269|PubMed:14765126,ECO:0000269|PubMed:16449642, ECO:0000269|PubMed:16818776,ECO:0000269|PubMed:16858404, ECO:0000269|PubMed:18004385,ECO:0000269|PubMed:18485871}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SUV39H1_SUV39H1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SUV39H1_SUV39H1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SUV39H1_SUV39H1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SUV39H1_SUV39H1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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