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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36805

FusionGeneSummary for SURF4_SURF4

check button Fusion gene summary
Fusion gene informationFusion gene name: SURF4_SURF4
Fusion gene ID: 36805
HgeneTgene
Gene symbol

SURF4

SURF4

Gene ID

6836

6836

Gene namesurfeit 4surfeit 4
SynonymsERV29ERV29
Cytomap

9q34.2

9q34.2

Type of geneprotein-codingprotein-coding
Descriptionsurfeit locus protein 4surface 4 integral membrane proteinsurfeit locus protein 4surface 4 integral membrane protein
Modification date2018051920180519
UniProtAcc

O15260

O15260

Ensembl transtripts involved in fusion geneENST00000371989, ENST00000485435, 
ENST00000545297, ENST00000467910, 
ENST00000371991, 
ENST00000371989, 
ENST00000485435, ENST00000545297, 
ENST00000467910, ENST00000371991, 
Fusion gene scores* DoF score5 X 5 X 1=255 X 5 X 2=50
# samples 55
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/50*10)=0
Context

PubMed: SURF4 [Title/Abstract] AND SURF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG403370SURF4chr9

136228773

+SURF4chr9

136228724

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000371989ENST00000371989SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371989ENST00000485435SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371989ENST00000545297SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371989ENST00000467910SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371989ENST00000371991SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-3UTRENST00000485435ENST00000371989SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000485435ENST00000485435SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000485435ENST00000545297SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000485435ENST00000467910SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000485435ENST00000371991SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-3UTRENST00000545297ENST00000371989SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000545297ENST00000485435SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000545297ENST00000545297SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000545297ENST00000467910SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000545297ENST00000371991SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-3UTRENST00000467910ENST00000371989SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000467910ENST00000485435SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000467910ENST00000545297SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000467910ENST00000467910SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000467910ENST00000371991SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-3UTRENST00000371991ENST00000371989SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371991ENST00000485435SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371991ENST00000545297SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371991ENST00000467910SURF4chr9

136228773

+SURF4chr9

136228724

-
intron-intronENST00000371991ENST00000371991SURF4chr9

136228773

+SURF4chr9

136228724

-

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FusionProtFeatures for SURF4_SURF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SURF4

O15260

SURF4

O15260

May play a role in the maintenance of the architectureof the endoplasmic reticulum-Golgi intermediate compartment and ofthe Golgi. {ECO:0000269|PubMed:18287528}. May play a role in the maintenance of the architectureof the endoplasmic reticulum-Golgi intermediate compartment and ofthe Golgi. {ECO:0000269|PubMed:18287528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SURF4_SURF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SURF4_SURF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SURF4_SURF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SURF4_SURF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSURF4C0033578Prostatic Neoplasms1CTD_human
TgeneSURF4C0033578Prostatic Neoplasms1CTD_human