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Fusion gene ID: 36763 |
FusionGeneSummary for SUN2_MED10 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SUN2_MED10 | Fusion gene ID: 36763 | Hgene | Tgene | Gene symbol | SUN2 | MED10 | Gene ID | 25777 | 84246 |
Gene name | Sad1 and UNC84 domain containing 2 | mediator complex subunit 10 | |
Synonyms | UNC84B | L6|NUT2|TRG20 | |
Cytomap | 22q13.1 | 5p15.31 | |
Type of gene | protein-coding | protein-coding | |
Description | SUN domain-containing protein 2Sad1 unc-84 domain protein 2nuclear envelope proteinprotein unc-84 homolog Brab5-interacting proteinrab5IPsad1/unc-84 protein-like 2unc-84 homolog B | mediator of RNA polymerase II transcription subunit 10TRG-17TRG-20mediator of RNA polymerase II transcription, subunit 10transformation-related gene 17 proteintransformation-related gene 20 protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UH99 | Q9BTT4 | |
Ensembl transtripts involved in fusion gene | ENST00000405510, ENST00000216064, ENST00000405018, ENST00000406622, ENST00000411587, | ENST00000255764, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 3 X 2=24 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SUN2 [Title/Abstract] AND MED10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SUN2 | GO:0090286 | cytoskeletal anchoring at nuclear membrane | 18396275 |
Hgene | SUN2 | GO:0090292 | nuclear matrix anchoring at nuclear membrane | 19933576 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AY453399 | SUN2 | chr22 | 39175441 | - | MED10 | chr5 | 6372712 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000405510 | ENST00000255764 | SUN2 | chr22 | 39175441 | - | MED10 | chr5 | 6372712 | - |
intron-3CDS | ENST00000216064 | ENST00000255764 | SUN2 | chr22 | 39175441 | - | MED10 | chr5 | 6372712 | - |
intron-3CDS | ENST00000405018 | ENST00000255764 | SUN2 | chr22 | 39175441 | - | MED10 | chr5 | 6372712 | - |
intron-3CDS | ENST00000406622 | ENST00000255764 | SUN2 | chr22 | 39175441 | - | MED10 | chr5 | 6372712 | - |
intron-3CDS | ENST00000411587 | ENST00000255764 | SUN2 | chr22 | 39175441 | - | MED10 | chr5 | 6372712 | - |
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FusionProtFeatures for SUN2_MED10 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SUN2 | MED10 |
As a component of the LINC (LInker of Nucleoskeleton andCytoskeleton) complex, involved in the connection between thenuclear lamina and the cytoskeleton. The nucleocytoplasmicinteractions established by the LINC complex play an importantrole in the transmission of mechanical forces across the nuclearenvelope and in nuclear movement and positioning. Specifically,SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cablesand couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclearmigration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebralcortex and during glial migration. Required for nuclear migrationin retinal photoreceptor progenitors implicating association withcytoplasmic dynein-dynactin and kinesin motor complexes, andprobably B-type lamins; SUN1 and SUN2 seem to act redundantly. TheSUN1/2:KASH5 LINC complex couples telomeres to microtubules duringmeiosis; SUN1 and SUN2 seem to act at least partial redundantly.Anchors chromosome movement in the prophase of meiosis and isinvolved in selective gene expression of coding and non-codingRNAs needed for gametogenesis. Required for telomere attachment tonuclear envelope and gametogenesis. May also function on endocyticvesicles as a receptor for RAB5-GDP and participate in theactivation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4,ECO:0000269|PubMed:18396275, ECO:0000305}. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SUN2_MED10 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SUN2_MED10 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SUN2_MED10 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SUN2_MED10 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |