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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36762

FusionGeneSummary for SUN2_GTPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SUN2_GTPBP1
Fusion gene ID: 36762
HgeneTgene
Gene symbol

SUN2

GTPBP1

Gene ID

25777

9567

Gene nameSad1 and UNC84 domain containing 2GTP binding protein 1
SynonymsUNC84BGP-1|GP1|HSPC018
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
DescriptionSUN domain-containing protein 2Sad1 unc-84 domain protein 2nuclear envelope proteinprotein unc-84 homolog Brab5-interacting proteinrab5IPsad1/unc-84 protein-like 2unc-84 homolog BGTP-binding protein 1G-protein 1
Modification date2018052320180523
UniProtAcc

Q9UH99

O00178

Ensembl transtripts involved in fusion geneENST00000405510, ENST00000216064, 
ENST00000405018, ENST00000406622, 
ENST00000411587, 		ENST00000216044, 
ENST00000460605, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 8 X 5=400
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SUN2 [Title/Abstract] AND GTPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUN2

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

HgeneSUN2

GO:0090292

nuclear matrix anchoring at nuclear membrane

19933576


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TQ-A7RH-01ASUN2chr22

39146230

-GTPBP1chr22

39111912

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000405510ENST00000216044SUN2chr22

39146230

-GTPBP1chr22

39111912

+
5CDS-intronENST00000405510ENST00000460605SUN2chr22

39146230

-GTPBP1chr22

39111912

+
Frame-shiftENST00000216064ENST00000216044SUN2chr22

39146230

-GTPBP1chr22

39111912

+
5CDS-intronENST00000216064ENST00000460605SUN2chr22

39146230

-GTPBP1chr22

39111912

+
Frame-shiftENST00000405018ENST00000216044SUN2chr22

39146230

-GTPBP1chr22

39111912

+
5CDS-intronENST00000405018ENST00000460605SUN2chr22

39146230

-GTPBP1chr22

39111912

+
Frame-shiftENST00000406622ENST00000216044SUN2chr22

39146230

-GTPBP1chr22

39111912

+
5CDS-intronENST00000406622ENST00000460605SUN2chr22

39146230

-GTPBP1chr22

39111912

+
In-frameENST00000411587ENST00000216044SUN2chr22

39146230

-GTPBP1chr22

39111912

+
5CDS-intronENST00000411587ENST00000460605SUN2chr22

39146230

-GTPBP1chr22

39111912

+

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FusionProtFeatures for SUN2_GTPBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUN2

Q9UH99

GTPBP1

O00178

As a component of the LINC (LInker of Nucleoskeleton andCytoskeleton) complex, involved in the connection between thenuclear lamina and the cytoskeleton. The nucleocytoplasmicinteractions established by the LINC complex play an importantrole in the transmission of mechanical forces across the nuclearenvelope and in nuclear movement and positioning. Specifically,SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cablesand couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclearmigration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebralcortex and during glial migration. Required for nuclear migrationin retinal photoreceptor progenitors implicating association withcytoplasmic dynein-dynactin and kinesin motor complexes, andprobably B-type lamins; SUN1 and SUN2 seem to act redundantly. TheSUN1/2:KASH5 LINC complex couples telomeres to microtubules duringmeiosis; SUN1 and SUN2 seem to act at least partial redundantly.Anchors chromosome movement in the prophase of meiosis and isinvolved in selective gene expression of coding and non-codingRNAs needed for gametogenesis. Required for telomere attachment tonuclear envelope and gametogenesis. May also function on endocyticvesicles as a receptor for RAB5-GDP and participate in theactivation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4,ECO:0000269|PubMed:18396275, ECO:0000305}. Promotes degradation of target mRNA species. Plays arole in the regulation of circadian mRNA stability. Binds GTP andhas GTPase activity (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518100_105173718Compositional biasNote=Poly-Arg
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-5182_164173718Compositional biasNote=Ser-rich
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518100_105194739Compositional biasNote=Poly-Arg
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-5182_164194739Compositional biasNote=Ser-rich
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619100_105173718Compositional biasNote=Poly-Arg
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-6192_164173718Compositional biasNote=Ser-rich
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619100_105173718Compositional biasNote=Poly-Arg
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-6192_164173718Compositional biasNote=Ser-rich
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-5181_139173718RegionLMNA-binding
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-5181_139194739RegionLMNA-binding
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-6191_139173718RegionLMNA-binding
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-6191_139173718RegionLMNA-binding
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112158_389101670Domaintr-type G
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112252_256101670Nucleotide bindingGTP
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112167_174101670RegionG1
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112206_210101670RegionG2
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112252_255101670RegionG3
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112308_311101670RegionG4
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+112366_368101670RegionG5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518273_296173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518348_440173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518475_506173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518273_296194739Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518348_440194739Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518475_506194739Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619273_296173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619348_440173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619475_506173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619273_296173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619348_440173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619475_506173718Coiled coilOntology_term=ECO:0000255
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518316_322173718Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518468_471173718Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518316_322194739Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518468_471194739Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619316_322173718Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619468_471173718Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619316_322173718Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619468_471173718Compositional biasNote=Poly-Gly
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518555_716173718DomainSUN
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518555_716194739DomainSUN
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619555_716173718DomainSUN
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619555_716173718DomainSUN
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-5181_212173718Topological domainNuclear
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518234_717173718Topological domainPerinuclear space
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-5181_212194739Topological domainNuclear
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518234_717194739Topological domainPerinuclear space
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-6191_212173718Topological domainNuclear
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619234_717173718Topological domainPerinuclear space
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-6191_212173718Topological domainNuclear
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619234_717173718Topological domainPerinuclear space
HgeneSUN2chr22:39146230chr22:39111912ENST00000216064-518213_233173718TransmembraneNote=Helical
HgeneSUN2chr22:39146230chr22:39111912ENST00000405018-518213_233194739TransmembraneNote=Helical
HgeneSUN2chr22:39146230chr22:39111912ENST00000405510-619213_233173718TransmembraneNote=Helical
HgeneSUN2chr22:39146230chr22:39111912ENST00000406622-619213_233173718TransmembraneNote=Helical
TgeneGTPBP1chr22:39146230chr22:39111912ENST00000216044+11228_36101670Compositional biasNote=Poly-Ala


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FusionGeneSequence for SUN2_GTPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SUN2_GTPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SUN2RAB5C, HGS, USP20, BTRC, FBXW11, AGO3, SYNE1, SYNE2, C9orf3, TP53BP1, RAB5A, RAB5B, RPS20, NRM, MAPK8, PRKAA1, SCARA3, GOLGA7B, NTRK1, SCARNA22, IFI16, TCTN3, GOLT1B, CTDNEP1, FKBP14, DHRS4, COPS7B, CSGALNACT2, CAV3, PIK3CA, UGP2, ZNRF4, MPPE1, FBXL4, PIP4K2C, GLTSCR2, PIP4K2B, METAP2, POTEF, PIP4K2A, TJP1, CHMP6, ACADS, PCDHB7, LMNA, TRIM25, YAP1GTPBP1IRF5, RAD21, HDGF, CUL3, COPS5, CAND1, APP, RAB17, CER1, EEF2KMT, VASP, EIF2S3, NHP2L1, NXF1, PRC1, NTRK1, SPICE1, CEP135, SCLT1, STIL, CHAMP1, NF2, CDC5L, MEX3C, CORO1C, SNRNP70, ISOC2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SUN2_GTPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SUN2_GTPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource