|
Fusion gene ID: 36755 |
FusionGeneSummary for SUMO2_POLR2K |
Fusion gene summary |
Fusion gene information | Fusion gene name: SUMO2_POLR2K | Fusion gene ID: 36755 | Hgene | Tgene | Gene symbol | SUMO2 | POLR2K | Gene ID | 6613 | 5440 |
Gene name | small ubiquitin-like modifier 2 | RNA polymerase II subunit K | |
Synonyms | HSMT3|SMT3B|SMT3H2|SUMO3|Smt3A | ABC10-alpha|RPABC4|RPB10alpha|RPB12|RPB7.0|hRPB7.0|hsRPB10a | |
Cytomap | 17q25.1 | 8q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | small ubiquitin-related modifier 2SMT3 homolog 2SMT3 suppressor of mif two 3 homolog 2sentrin 2ubiquitin-like protein SMT3Aubiquitin-like protein SMT3B | DNA-directed RNA polymerases I, II, and III subunit RPABC4DNA directed RNA polymerases I, II, and III 7.0 kda polypeptideDNA-directed RNA polymerase II subunit KRNA polymerase II 7.0 kDa subunitRNA polymerases I, II, and III subunit ABC4polymerase (R | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P61956 | P53803 | |
Ensembl transtripts involved in fusion gene | ENST00000420826, ENST00000314523, ENST00000578238, | ENST00000353107, ENST00000522439, ENST00000519765, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 2 X 3=30 |
# samples | 3 | 5 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SUMO2 [Title/Abstract] AND POLR2K [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SUMO2 | GO:0016925 | protein sumoylation | 17081986|17696781|21965678|24105744 |
Hgene | SUMO2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 18408734 |
Tgene | POLR2K | GO:0006366 | transcription by RNA polymerase II | 9852112 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-61-1738-01A | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000420826 | ENST00000353107 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
5CDS-5UTR | ENST00000420826 | ENST00000522439 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
5CDS-3UTR | ENST00000420826 | ENST00000519765 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
5CDS-5UTR | ENST00000314523 | ENST00000353107 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
5CDS-5UTR | ENST00000314523 | ENST00000522439 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
5CDS-3UTR | ENST00000314523 | ENST00000519765 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
intron-5UTR | ENST00000578238 | ENST00000353107 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
intron-5UTR | ENST00000578238 | ENST00000522439 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
intron-3UTR | ENST00000578238 | ENST00000519765 | SUMO2 | chr17 | 73178909 | - | POLR2K | chr8 | 101163575 | + |
Top |
FusionProtFeatures for SUMO2_POLR2K |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SUMO2 | POLR2K |
Ubiquitin-like protein that can be covalently attachedto proteins as a monomer or as a lysine-linked polymer. Covalentattachment via an isopeptide bond to its substrates requires prioractivation by the E1 complex SAE1-SAE2 and linkage to the E2enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4,RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translationalmodification on lysine residues of proteins plays a crucial rolein a number of cellular processes such as nuclear transport, DNAreplication and repair, mitosis and signal transduction. PolymericSUMO2 chains are also susceptible to polyubiquitination whichfunctions as a signal for proteasomal degradation of modifiedproteins (PubMed:18408734, PubMed:18538659, PubMed:21965678,PubMed:9556629). Plays a role in the regulation of sumoylationstatus of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734,ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494,ECO:0000269|PubMed:9556629}. | DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Common component of RNA polymerases I, II and IIIwhich synthesize ribosomal RNA precursors, mRNA precursors andmany functional non-coding RNAs, and a small RNAs, such as 5S rRNAand tRNAs, respectively. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SUMO2_POLR2K |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SUMO2_POLR2K |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SUMO2 | MAF1, VIM, CHD3, TRIM63, SENP3, ZMYM2, PIAS1, USP28, SAE1, UBA2, UBE2I, CHAF1A, RCOR1, KDM1A, RNF4, CMTM6, BAD, CSNK2B, SETDB1, ALAS1, PML, DAXX, ELAVL1, UIMC1, BRCA1, BRE, FAM175A, BRCC3, ATXN7, USP25, SENP6, PIAS4, PIAS2, USPL1, PIAS3, IGBP1, SSSCA1, AHCYL1, CTSA, SELENBP1, PSAP, ATIC, SDHAF2, RNF111, CASP8AP2, SIMC1, VCP, MYB, NFE2L2, SLC22A2, TEAD3, SP100, TNIP1, MAST2, TDG, TOPORS, RANBP2, ZCCHC7, ZCCHC12, ZMYM5, ZHX1, SETX, BLM, WRN, TDP2, C18orf25, SENP1, SUMO2, SHFM1, SENP7, IRF7, SENP5, HOMEZ, SENP2, TANK, EP300, UBC, ZBTB1, ZBTB21, KRT5, NOP58, SOBP, HIPK2, AHNAK, ANXA1, ATF7IP, ATRX, BAZ1A, BAZ1B, SLX4, SLX4IP, CAD, CARS, CHAF1B, CHD4, CTNND1, CUX1, DCD, DDX17, DDX21, DDX3X, PRKDC, EEF1A1, EEF1G, EME1, ENO1, ERCC4, EXOSC10, EXOSC9, GATAD2B, HDAC1, HDAC2, HNRNPF, HNRNPH1, HNRNPK, HP1BP3, HSP90AB1, HSPA1A, HSPA8, HSPA9, IPO5, LAS1L, MDC1, MDN1, MKI67, MRE11A, MSH2, MTA1, MTA2, MUS81, NBN, NOL9, NOP2, NUMA1, PARN, PELP1, PFKM, PHF5A, PHF8, POGZ, RAD50, RAD54L2, RBBP4, RBBP7, RCOR2, RCOR3, RPL3, RPL4, RUVBL1, SMCHD1, SSRP1, SUPT16H, TEX10, TMPO, TOP2A, TOP2B, TP53BP1, TPR, TRAF1, TRIM26, TRIM28, TRIML2, TUBA1B, TUBB, TUBB4B, TUBB6, XRCC5, XRCC6, ZBED1, ZBTB2, ZBTB25, ZBTB33, ZMAT3, ZMYM4, ZNF451, ZNF496, CHAMP1, ZMYM3, ALDOA, NPEPL1, PGD, SEC23A, SEC23B, ENO2, EWSR1, NUP153, RNF168, USP11, USP7, DNM1L, HSD17B10, SOD1, RNF8 | POLR2K | MED10, POLR2C, POLR2A, POLR2B, POLR2E, POLR2F, POLR2G, POLR2H, POLR2K, POLR2J, APP, MED26, MED19, ESR1, SRC, PSMB9, TCEB3, MOV10, POLR1C, POLR2I, XPO1, POLR1A, POLR3E, FBXW7 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SUMO2_POLR2K |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SUMO2_POLR2K |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |