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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36755

FusionGeneSummary for SUMO2_POLR2K

check button Fusion gene summary
Fusion gene informationFusion gene name: SUMO2_POLR2K
Fusion gene ID: 36755
HgeneTgene
Gene symbol

SUMO2

POLR2K

Gene ID

6613

5440

Gene namesmall ubiquitin-like modifier 2RNA polymerase II subunit K
SynonymsHSMT3|SMT3B|SMT3H2|SUMO3|Smt3AABC10-alpha|RPABC4|RPB10alpha|RPB12|RPB7.0|hRPB7.0|hsRPB10a
Cytomap

17q25.1

8q22.2

Type of geneprotein-codingprotein-coding
Descriptionsmall ubiquitin-related modifier 2SMT3 homolog 2SMT3 suppressor of mif two 3 homolog 2sentrin 2ubiquitin-like protein SMT3Aubiquitin-like protein SMT3BDNA-directed RNA polymerases I, II, and III subunit RPABC4DNA directed RNA polymerases I, II, and III 7.0 kda polypeptideDNA-directed RNA polymerase II subunit KRNA polymerase II 7.0 kDa subunitRNA polymerases I, II, and III subunit ABC4polymerase (R
Modification date2018052320180523
UniProtAcc

P61956

P53803

Ensembl transtripts involved in fusion geneENST00000420826, ENST00000314523, 
ENST00000578238, 
ENST00000353107, 
ENST00000522439, ENST00000519765, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 2 X 3=30
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SUMO2 [Title/Abstract] AND POLR2K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUMO2

GO:0016925

protein sumoylation

17081986|17696781|21965678|24105744

HgeneSUMO2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

18408734

TgenePOLR2K

GO:0006366

transcription by RNA polymerase II

9852112


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1738-01ASUMO2chr17

73178909

-POLR2Kchr8

101163575

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000420826ENST00000353107SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
5CDS-5UTRENST00000420826ENST00000522439SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
5CDS-3UTRENST00000420826ENST00000519765SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
5CDS-5UTRENST00000314523ENST00000353107SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
5CDS-5UTRENST00000314523ENST00000522439SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
5CDS-3UTRENST00000314523ENST00000519765SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
intron-5UTRENST00000578238ENST00000353107SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
intron-5UTRENST00000578238ENST00000522439SUMO2chr17

73178909

-POLR2Kchr8

101163575

+
intron-3UTRENST00000578238ENST00000519765SUMO2chr17

73178909

-POLR2Kchr8

101163575

+

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FusionProtFeatures for SUMO2_POLR2K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUMO2

P61956

POLR2K

P53803

Ubiquitin-like protein that can be covalently attachedto proteins as a monomer or as a lysine-linked polymer. Covalentattachment via an isopeptide bond to its substrates requires prioractivation by the E1 complex SAE1-SAE2 and linkage to the E2enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4,RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translationalmodification on lysine residues of proteins plays a crucial rolein a number of cellular processes such as nuclear transport, DNAreplication and repair, mitosis and signal transduction. PolymericSUMO2 chains are also susceptible to polyubiquitination whichfunctions as a signal for proteasomal degradation of modifiedproteins (PubMed:18408734, PubMed:18538659, PubMed:21965678,PubMed:9556629). Plays a role in the regulation of sumoylationstatus of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734,ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494,ECO:0000269|PubMed:9556629}. DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Common component of RNA polymerases I, II and IIIwhich synthesize ribosomal RNA precursors, mRNA precursors andmany functional non-coding RNAs, and a small RNAs, such as 5S rRNAand tRNAs, respectively.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SUMO2_POLR2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SUMO2_POLR2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SUMO2MAF1, VIM, CHD3, TRIM63, SENP3, ZMYM2, PIAS1, USP28, SAE1, UBA2, UBE2I, CHAF1A, RCOR1, KDM1A, RNF4, CMTM6, BAD, CSNK2B, SETDB1, ALAS1, PML, DAXX, ELAVL1, UIMC1, BRCA1, BRE, FAM175A, BRCC3, ATXN7, USP25, SENP6, PIAS4, PIAS2, USPL1, PIAS3, IGBP1, SSSCA1, AHCYL1, CTSA, SELENBP1, PSAP, ATIC, SDHAF2, RNF111, CASP8AP2, SIMC1, VCP, MYB, NFE2L2, SLC22A2, TEAD3, SP100, TNIP1, MAST2, TDG, TOPORS, RANBP2, ZCCHC7, ZCCHC12, ZMYM5, ZHX1, SETX, BLM, WRN, TDP2, C18orf25, SENP1, SUMO2, SHFM1, SENP7, IRF7, SENP5, HOMEZ, SENP2, TANK, EP300, UBC, ZBTB1, ZBTB21, KRT5, NOP58, SOBP, HIPK2, AHNAK, ANXA1, ATF7IP, ATRX, BAZ1A, BAZ1B, SLX4, SLX4IP, CAD, CARS, CHAF1B, CHD4, CTNND1, CUX1, DCD, DDX17, DDX21, DDX3X, PRKDC, EEF1A1, EEF1G, EME1, ENO1, ERCC4, EXOSC10, EXOSC9, GATAD2B, HDAC1, HDAC2, HNRNPF, HNRNPH1, HNRNPK, HP1BP3, HSP90AB1, HSPA1A, HSPA8, HSPA9, IPO5, LAS1L, MDC1, MDN1, MKI67, MRE11A, MSH2, MTA1, MTA2, MUS81, NBN, NOL9, NOP2, NUMA1, PARN, PELP1, PFKM, PHF5A, PHF8, POGZ, RAD50, RAD54L2, RBBP4, RBBP7, RCOR2, RCOR3, RPL3, RPL4, RUVBL1, SMCHD1, SSRP1, SUPT16H, TEX10, TMPO, TOP2A, TOP2B, TP53BP1, TPR, TRAF1, TRIM26, TRIM28, TRIML2, TUBA1B, TUBB, TUBB4B, TUBB6, XRCC5, XRCC6, ZBED1, ZBTB2, ZBTB25, ZBTB33, ZMAT3, ZMYM4, ZNF451, ZNF496, CHAMP1, ZMYM3, ALDOA, NPEPL1, PGD, SEC23A, SEC23B, ENO2, EWSR1, NUP153, RNF168, USP11, USP7, DNM1L, HSD17B10, SOD1, RNF8POLR2KMED10, POLR2C, POLR2A, POLR2B, POLR2E, POLR2F, POLR2G, POLR2H, POLR2K, POLR2J, APP, MED26, MED19, ESR1, SRC, PSMB9, TCEB3, MOV10, POLR1C, POLR2I, XPO1, POLR1A, POLR3E, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SUMO2_POLR2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SUMO2_POLR2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource